gene 884 words KG: TLR2
Contents

TLR2 — Toll-Like Receptor 2

🧬 Gene Info
Gene SymbolTLR2
Full NameToll-Like Receptor 2
Chromosome4q31.3
Protein TypeReceptor
FunctionTLR2 is expressed in microglia, astrocytes, and neurons throughout the brain.
Primary Expressionmicroglia, astrocytes, and neurons throughout the brain
Amino Acids784 aa
Exons3
PathwaysNF-κB, PI3K
UniProt IDQ9Y257
NCBI Gene ID7103
Ensembl IDENSG00000137462
OMIM603028
GeneCardsTLR2
Human Protein AtlasTLR2
Associated DiseasesAls, Alzheimer, Brain Injury, Fibrosis, HYPOXIC-ISCHEMIC ENCEPHALOPATHY
Known Drugs/CompoundsC29
InteractionsAKT, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND
KG Connections685 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (20)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE-TREM2 Interaction Modulation
Score: 0.74
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Microbial Inflammasome Priming Prevention
Score: 0.65
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (9)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (4)

Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90
TLR expression analysis in Parkinson's disease patients
clinical · proposed · Score: 0.85
TLR expression in α-synuclein overexpressing mice
validation · proposed · Score: 0.80
NLRP3 Inflammasome Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (4)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
AIFM1 Gene
gene · KG edge: expressed_in
Alzheimer Indonesia
institution · KG edge: associated_with

Knowledge Graph (12 edges)

TLR2 regulates C3
LAMP2 therapeutic_target TLR2
TFRC therapeutic_target TLR2
PPP1CB therapeutic_target TLR2
TLR2 therapeutic_target MTOR
TLR2 therapeutic_target BID
TLR2 therapeutic_target BAD
CD47 associated_with TLR2
TLR2 associated_with CD36
TLR2 interacts_with CMKLR1

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