concept

ACTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1568Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	ACTIN
Key Genes/Proteins	4E-BP1, ABCA1, ABCD3, ABCG1, ACTB, ALZHEIMER DISEASE
Related Diseases	ALS, ATHEROSCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Actin Cytoskeleton Dynamics in Neurodegeneration

mechanism · 3067 words

→

Pathway Diagram

graph TD
    ACTIN["ACTIN"]
    style ACTIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ACTIN -->|"interacts"| Dementia["Dementia"]
    ACTIN -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ACTIN -->|"interacts"| Als["Als"]
    ACTIN -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ACTIN -->|"interacts"| Alzheimer["Alzheimer"]
    ACTIN -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    ACTIN -->|"interacts"| Parkinson["Parkinson"]
    ACTIN -.->|"protects against"| Neurodegeneration["Neurodegeneration"]
    PIEZO1([PIEZO1]) -->|"regulates"| ACTIN
    FUS([FUS]) -->|"interacts"| ACTIN
    TAX1BP1([TAX1BP1]) -->|"interacts"| ACTIN
    ALS([ALS]) -->|"interacts"| ACTIN
    TOLLIP([TOLLIP]) -->|"interacts"| ACTIN
    G3BP1([G3BP1]) -->|"interacts"| ACTIN
    ULK1([ULK1]) -->|"interacts"| ACTIN
    DEMENTIA([DEMENTIA]) -->|"interacts"| ACTIN
    GFP([GFP]) -->|"interacts"| ACTIN
    CALCOCO2([CALCOCO2]) -->|"interacts"| ACTIN

Outgoing (437)

Target	Relation	Type	Str
macrophage activation	drives	process	0.80
microtubule	interacts_with	protein	0.75
Senescence	activates	disease	0.60
Necroptosis	regulates	disease	0.60
Neuropathy	causes	disease	0.60
Neurodegeneration	contributes_to	disease	0.60
Neuroinflammation	causes	disease	0.60
Encephalitis	interacts_with	disease	0.60
Neuroinflammation	interacts_with	disease	0.60
Multiple Sclerosis	therapeutic_target	disease	0.60
Parkinson	regulates	disease	0.60
Opioid	inhibits	disease	0.60
Chronic Pain	inhibits	disease	0.60
Cardiomyopathy	regulates	disease	0.60
Cancer	biomarker_for	disease	0.60
Epilepsy	therapeutic_target	disease	0.60
Diabetes	regulates	disease	0.60
Necroptosis	biomarker_for	disease	0.60
Neuroinflammation	expressed_in	disease	0.60
Stroke	expressed_in	disease	0.60
Als	biomarker_for	disease	0.60
Aging	activates	disease	0.60
Anxiety	activates	disease	0.60
Pyroptosis	activates	disease	0.60
Alzheimer	transports	disease	0.60
Aging	causes	disease	0.60
Diabetes	protects_against	disease	0.60
Fibrosis	expressed_in	disease	0.60
Necroptosis	expressed_in	disease	0.60
Atherosclerosis	associated_with	disease	0.60
Anxiety	contributes_to	disease	0.60
Glioblastoma	activates	disease	0.60
Amyotrophic Lateral Sclerosis	regulates	disease	0.60
Obesity	activates	disease	0.60
Als	protects_against	disease	0.60
Alzheimer	inhibits	disease	0.60
Prion Disease	interacts_with	disease	0.60
Retinopathy	therapeutic_target	disease	0.60
Neuroinflammation	regulates	disease	0.60
Als	phosphorylates	disease	0.60
Frontotemporal Dementia	associated_with	disease	0.60
Dementia	associated_with	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Fibrosis	activates	disease	0.60
Anxiety	regulates	disease	0.60
Alzheimer	regulates	disease	0.60
Parkinson	causes	disease	0.60
Neurodegeneration	regulates	disease	0.60
Tauopathy	activates	disease	0.60
Encephalitis	therapeutic_target	disease	0.60

Incoming (1131)

Source	Relation	Type	Str
PIEZO1	interacts_with	gene	0.85
Piezo1	positively_regulates	gene	0.70
PIEZO1	regulates	protein	0.64
MICROGLIA	activates	gene	0.60
BECN1	associated_with	gene	0.60
ATG8	associated_with	gene	0.60
ATF4	associated_with	gene	0.60
ATG	associated_with	gene	0.60
PIEZO1	activates	gene	0.60
JUN	interacts_with	gene	0.60
RNA	associated_with	gene	0.60
LYSOSOME	associated_with	gene	0.60
GABA	associated_with	gene	0.60
LGALS8	interacts_with	gene	0.60
TIA1	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
FMR1	associated_with	gene	0.60
CNO	therapeutic_target	gene	0.60
PER	therapeutic_target	gene	0.60
VIM	regulates	gene	0.60
WT1	regulates	gene	0.60
OCLN	regulates	gene	0.60
ATG14	associated_with	gene	0.60
VIMENTIN	regulates	gene	0.60
HDAC6	activates	gene	0.60
TUBULIN	activates	gene	0.60
MAP3K5	regulates	gene	0.60
TJP1	regulates	gene	0.60
GJA1	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
H2AX	associated_with	gene	0.60
RAC1	regulates	gene	0.60
G3BP1	associated_with	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
APOE	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
APOE4	therapeutic_target	gene	0.60
AKT	activates	gene	0.60
CAMKII	activates	gene	0.60
AMPK	activates	gene	0.60
FOXO1	activates	gene	0.60
FOXO4	activates	gene	0.60
SMN1	associated_with	gene	0.60
ALS	associated_with	gene	0.60
HTT	associated_with	gene	0.60
DNMT1	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
DNA	associated_with	gene	0.60
SETX	associated_with	gene	0.60
HUNTINGTIN	associated_with	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-ABI3 actin-phagocytosis coupling is a higher-yield AD	0.620	alzheimers	-
Microglial priming is primarily epigenetic, with metabolic c	0.609	neuroinflammation	Do microglia actually switch between gly
Structure-interacting small molecules that stabilize the APO	0.580	neuroscience	APOE4-driven lipid metabolism dysregulat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Longitudinal dietary change analysis and ADRD risk over 10 years	clinical	Alzheimer's disease and relate	0.930	0.00	human patients	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACTIN in their description or question text

No additional research found