concept

ACTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1568Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	ACTIN
Key Genes/Proteins	4E-BP1, ABCA1, ABCD3, ABCG1, ACTB, ALZHEIMER DISEASE
Related Diseases	ALS, ATHEROSCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Actin Cytoskeleton Dynamics in Neurodegeneration

mechanism · 3067 words

→

Pathway Diagram

graph TD
    ACTIN["ACTIN"]
    style ACTIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ACTIN -->|"interacts"| Dementia["Dementia"]
    ACTIN -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ACTIN -->|"interacts"| Als["Als"]
    ACTIN -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ACTIN -->|"interacts"| Alzheimer["Alzheimer"]
    ACTIN -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    ACTIN -->|"interacts"| Parkinson["Parkinson"]
    ACTIN -.->|"protects against"| Neurodegeneration["Neurodegeneration"]
    PIEZO1([PIEZO1]) -->|"regulates"| ACTIN
    FUS([FUS]) -->|"interacts"| ACTIN
    TAX1BP1([TAX1BP1]) -->|"interacts"| ACTIN
    ALS([ALS]) -->|"interacts"| ACTIN
    TOLLIP([TOLLIP]) -->|"interacts"| ACTIN
    G3BP1([G3BP1]) -->|"interacts"| ACTIN
    ULK1([ULK1]) -->|"interacts"| ACTIN
    DEMENTIA([DEMENTIA]) -->|"interacts"| ACTIN
    GFP([GFP]) -->|"interacts"| ACTIN
    CALCOCO2([CALCOCO2]) -->|"interacts"| ACTIN

Outgoing (437)

Target	Relation	Type	Str
macrophage activation	drives	process	0.80
microtubule	interacts_with	protein	0.75
Depression	interacts_with	disease	0.60
Huntington	interacts_with	disease	0.60
Cancer	expressed_in	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Huntington	therapeutic_target	disease	0.60
Ischemia	therapeutic_target	disease	0.60
Neurodegeneration	interacts_with	disease	0.60
Frontotemporal Dementia	inhibits	disease	0.60
Dementia	inhibits	disease	0.60
Amyotrophic Lateral Sclerosis	inhibits	disease	0.60
Ferroptosis	inhibits	disease	0.60
Neurodegeneration	regulates	disease	0.60
Tauopathy	activates	disease	0.60
Encephalitis	therapeutic_target	disease	0.60
Ischemia	inhibits	disease	0.60
Stroke	inhibits	disease	0.60
Spinal Cord Injury	inhibits	disease	0.60
Schizophrenia	regulates	disease	0.60
Neurodegeneration	expressed_in	disease	0.60
Alzheimer	inhibits	disease	0.60
Retinopathy	therapeutic_target	disease	0.60
Prion Disease	interacts_with	disease	0.60
Leukemia	activates	disease	0.60
Als	encodes	disease	0.60
Neuropathy	activates	disease	0.60
Neuroinflammation	inhibits	disease	0.60
Neuropathy	regulates	disease	0.60
Parkinson	protects_against	disease	0.60
Anxiety	activates	disease	0.60
Spinal Muscular Atrophy	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Depression	associated_with	disease	0.60
Aging	regulates	disease	0.60
Anxiety	regulates	disease	0.60
Neuroinflammation	regulates	disease	0.60
Alzheimer	regulates	disease	0.60
Parkinson	causes	disease	0.60
Als	interacts_with	disease	0.60
Als	transports	disease	0.60
Alzheimer	interacts_with	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Depression	regulates	disease	0.60
Multiple Sclerosis	regulates	disease	0.60
Dementia	activates	disease	0.60
Neurodegeneration	protects_against	disease	0.60
Diabetes	inhibits	disease	0.60
Cardiomyopathy	inhibits	disease	0.60

Incoming (1131)

Source	Relation	Type	Str
PIEZO1	interacts_with	gene	0.85
Piezo1	positively_regulates	gene	0.70
PIEZO1	regulates	protein	0.64
ATP	expressed_in	gene	0.60
GJA1	activates	gene	0.60
ROS	expressed_in	gene	0.60
GJA1	interacts_with	gene	0.60
DRP1	expressed_in	gene	0.60
MITOPHAGY	degrades	gene	0.60
TERRA	activates	gene	0.60
TRAIL	activates	gene	0.60
TOMM20	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
PHB2	associated_with	gene	0.60
COX4I1	associated_with	gene	0.60
RIPK1	activates	gene	0.60
UBIQUITIN	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
BCL2L13	associated_with	gene	0.60
AGING	degrades	gene	0.60
BNIP3L	associated_with	gene	0.60
LC3	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
MTDNA	interacts_with	gene	0.60
TFAM	interacts_with	gene	0.60
GAP43	inhibits	gene	0.60
ERK	interacts_with	gene	0.60
TRAK1	expressed_in	gene	0.60
AXON	expressed_in	gene	0.60
MITOCHONDRIA	transports	gene	0.60
ROS	activates	gene	0.60
CX43	expressed_in	gene	0.60
CX43	interacts_with	gene	0.60
MITOCHONDRIA	expressed_in	gene	0.60
AUTOPHAGY	transports	gene	0.60
ALZHEIMER	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
EPILEPSY	activates	gene	0.60
DEPRESSION	activates	gene	0.60
GABA-A	activates	gene	0.60
RIPK3	activates	gene	0.60
BATF3	activates	gene	0.60
CD8	activates	gene	0.60
CDH1	activates	gene	0.60
CDK2	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
FZR1	activates	gene	0.60
RNA	activates	gene	0.60
ARF1	expressed_in	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-ABI3 actin-phagocytosis coupling is a higher-yield AD	0.620	Alzheimer's disease	-
Microglial priming is primarily epigenetic, with metabolic c	0.609	neuroinflammation	Do microglia actually switch between gly
Structure-interacting small molecules that stabilize the APO	0.580	neuroscience	APOE4-driven lipid metabolism dysregulat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Longitudinal dietary change analysis and ADRD risk over 10 years	clinical	Alzheimer's disease and relate	0.930	0.00	human patients	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACTIN in their description or question text

No additional research found