concept

ACTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1568Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	ACTIN
Key Genes/Proteins	4E-BP1, ABCA1, ABCD3, ABCG1, ACTB, ALZHEIMER DISEASE
Related Diseases	ALS, ATHEROSCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Actin Cytoskeleton Dynamics in Neurodegeneration

mechanism · 3067 words

→

Pathway Diagram

graph TD
    ACTIN["ACTIN"]
    style ACTIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ACTIN -->|"interacts"| Dementia["Dementia"]
    ACTIN -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ACTIN -->|"interacts"| Als["Als"]
    ACTIN -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ACTIN -->|"interacts"| Alzheimer["Alzheimer"]
    ACTIN -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    ACTIN -->|"interacts"| Parkinson["Parkinson"]
    ACTIN -.->|"protects against"| Neurodegeneration["Neurodegeneration"]
    PIEZO1([PIEZO1]) -->|"regulates"| ACTIN
    FUS([FUS]) -->|"interacts"| ACTIN
    TAX1BP1([TAX1BP1]) -->|"interacts"| ACTIN
    ALS([ALS]) -->|"interacts"| ACTIN
    TOLLIP([TOLLIP]) -->|"interacts"| ACTIN
    G3BP1([G3BP1]) -->|"interacts"| ACTIN
    ULK1([ULK1]) -->|"interacts"| ACTIN
    DEMENTIA([DEMENTIA]) -->|"interacts"| ACTIN
    GFP([GFP]) -->|"interacts"| ACTIN
    CALCOCO2([CALCOCO2]) -->|"interacts"| ACTIN

Outgoing (437)

Target	Relation	Type	Str
macrophage activation	drives	process	0.80
microtubule	interacts_with	protein	0.75
Depression	activates	disease	0.60
Migraine	activates	disease	0.60
Epilepsy	activates	disease	0.60
Huntington	activates	disease	0.60
Necroptosis	activates	disease	0.60
Als	phosphorylates	disease	0.60
Aging	inhibits	disease	0.60
Frontotemporal Dementia	therapeutic_target	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Parkinson	inhibits	disease	0.60
Als	inhibits	disease	0.60
Als	protects_against	disease	0.60
Aging	associated_with	disease	0.60
Cancer	inhibits	disease	0.60
Depression	inhibits	disease	0.60
Necroptosis	interacts_with	disease	0.60
Cancer	regulates	disease	0.60
Alzheimer	protects_against	disease	0.60
Diabetes	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Depression	interacts_with	disease	0.60
Als	regulates	disease	0.60
Glioblastoma	associated_with	disease	0.60
Dementia	protects_against	disease	0.60
Neuropathy	protects_against	disease	0.60
Cancer	phosphorylates	disease	0.60
Schizophrenia	activates	disease	0.60
Alzheimer	activates	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Huntington	therapeutic_target	disease	0.60
Alzheimer	associated_with	disease	0.60
Ischemia	therapeutic_target	disease	0.60
Depression	associated_with	disease	0.60
Cancer	biomarker_for	disease	0.60
Tauopathy	stabilizes	disease	0.60
Necroptosis	biomarker_for	disease	0.60
Als	biomarker_for	disease	0.60
Alzheimer	stabilizes	disease	0.60
Pyroptosis	activates	disease	0.60
Parkinson	activates	disease	0.60
Aging	causes	disease	0.60
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.60
Als	expressed_in	disease	0.60
Alzheimer	inhibits	disease	0.60
Retinopathy	therapeutic_target	disease	0.60
Prion Disease	interacts_with	disease	0.60
Cancer	activates	disease	0.60

Incoming (1131)

Source	Relation	Type	Str
PIEZO1	interacts_with	gene	0.85
Piezo1	positively_regulates	gene	0.70
PIEZO1	regulates	protein	0.64
CTSB	associated_with	gene	0.60
DMSO	associated_with	gene	0.60
JUN	activates	gene	0.60
SYT1	activates	gene	0.60
SYN1	activates	gene	0.60
RAS	associated_with	gene	0.60
SNAP25	activates	gene	0.60
WNT	associated_with	gene	0.60
CCND1	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
FAM83A	associated_with	gene	0.60
GSK3B	associated_with	gene	0.60
SLC6A3	activates	gene	0.60
SLC6A2	activates	gene	0.60
AXIN2	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
TSPAN1	associated_with	gene	0.60
TCF4	associated_with	gene	0.60
ALZHEIMER	stabilizes	gene	0.60
RAB7A	stabilizes	gene	0.60
TAU	stabilizes	gene	0.60
RAB35	stabilizes	gene	0.60
LYSOSOME	stabilizes	gene	0.60
ENDOSOME	stabilizes	gene	0.60
TAUOPATHY	stabilizes	gene	0.60
CHMP6	stabilizes	gene	0.60
TSG101	stabilizes	gene	0.60
DRD2	activates	gene	0.60
AXIN	associated_with	gene	0.60
MAP2	activates	gene	0.60
SNCA	activates	gene	0.60
SLC6A4	activates	gene	0.60
ABCB1	activates	gene	0.60
NUCKS1	activates	gene	0.60
CYP2D6	activates	gene	0.60
PARKINSON	activates	gene	0.60
LRRK2	activates	gene	0.60
GPNMB	activates	gene	0.60
GCH1	activates	gene	0.60
FBXL7	activates	gene	0.60
AURKA	interacts_with	gene	0.60
FOXP1	interacts_with	gene	0.60
SURVIVIN	activates	gene	0.60
TRAF2	interacts_with	gene	0.60
ALPK1	activates	gene	0.60
IL-1	activates	gene	0.60
RAB10	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-ABI3 actin-phagocytosis coupling is a higher-yield AD	0.620	alzheimers	-
Microglial priming is primarily epigenetic, with metabolic c	0.609	neuroinflammation	Do microglia actually switch between gly
Structure-interacting small molecules that stabilize the APO	0.580	neuroscience	APOE4-driven lipid metabolism dysregulat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Longitudinal dietary change analysis and ADRD risk over 10 years	clinical	Alzheimer's disease and relate	0.930	0.00	human patients	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACTIN in their description or question text

No additional research found