gene

PIEZO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIEZO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

978Connections

2Hypotheses

5Analyses

50Outgoing

50Incoming

3Experiments

20Debates

Summary

PIEZO1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 510 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PIEZO1
Full Name	Piezo Type Mechanosensitive Ion Channel Component 1
Chromosome	16q24.3
Protein Type	Ion Channel
Target Class	Ion Channel
Function	Small molecule modulator of mechanosensitive ion channel activity
Mechanism of Action	Small molecule modulator of mechanosensitive ion channel activity
Primary Expression	microglia, astrocytes, and brain endothelial cells, where it transduces mechanical cues from the ti
Druggability	Low (0.42)
Clinical Stage	Phase I
Molecular Weight	286 kDa
Amino Acids	521 aa
Exons	51
Pathways	Angiogenesis, Apoptosis, Autophagy, Calcium Signaling, Epigenetic
UniProt ID	Q9H5I5
NCBI Gene ID	9780
Ensembl ID	ENSG00000103335
OMIM	611184
GeneCards	PIEZO1
Human Protein Atlas	PIEZO1
Associated Diseases	Als, Alzheimer, Atherosclerosis, Bacterial Infection, calcium influx
Known Drugs/Compounds	artemisinin, Paeoniflorin, Yoda1
Interactions	Actin, ADAMTS5, AGING, AKT, ALS, ALZHEIMER'S DISEASE
SciDEX Target	View Target Profile (5 clinical trials)
SciDEX Hypotheses	Extracellular Matrix Stiffness Modulation Piezo1 Channel Inhibition Prevents Mechanical Ampl
KG Connections	925 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — PIEZO1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

5Z10 — X-ray / Cryo-EM

🔮 AI Predicted Structure

Q9H5I5 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PIEZO1 — Piezo Type Mechanosensitive Ion Channel Component 1

gene · 1444 words

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Pathway Diagram

graph TD
    PIEZO1["PIEZO1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    PIEZO1["PIEZO1"] -->|"interacts"| KCNK2["KCNK2"]
    PIEZO1["PIEZO1"] -->|"co discussed"| P2RX7["P2RX7"]
    PIEZO1["PIEZO1"] -->|"co discussed"| DGAT1["DGAT1"]
    PIEZO1["PIEZO1"] -->|"co discussed"| C3["C3"]
    PIEZO1["PIEZO1"] -->|"co discussed"| GABRA1["GABRA1"]
    KCNK2_1["KCNK2"] -->|"interacts"| PIEZO1["PIEZO1"]
    BMAL1["BMAL1"] -->|"co discussed"| PIEZO1["PIEZO1"]
    HK2["HK2"] -->|"co discussed"| PIEZO1["PIEZO1"]
    MIRO1["MIRO1"] -->|"co discussed"| PIEZO1["PIEZO1"]
    style PIEZO1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (717)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PIEZO1	data_in	dataset_row	0.00
PIEZO1	encodes	protein	0.00
TMEM16F	interacts_with	gene	1.00
Als	activates	disease	1.00
Liver Fibrosis Resolution	associated_with	phenotype	0.95
Stiffness Sensing	modulates	process	0.95
Macrophage Efferocytosis	associated_with	process	0.95
Central Nervous System	involved_in	process	0.95
Macrophage Polarization	modulates	process	0.95
Ca2+ influx	mediates	process	0.95
Renal Fibrosis	implicated_in	disease	0.95
Macrophage Efferocytosis	activates	process	0.95
mechanosensing	mediates	process	0.95
uterine contractions	associated_with	phenotype	0.95
Uterine Contractions	involved_in	phenotype	0.95
Hepatic Fibrosis	upregulates	disease	0.95
Tumor Cell Migration	regulates	process	0.95
Bone Mass	regulates	phenotype	0.95
Efferocytosis	activates	process	0.95
Lymphatic Endothelial Cells	expressed_in	cell_type	0.95
Parturition	involved_in	process	0.95
Tumor Cell Proliferation	regulates	process	0.95
Muscle Mass	regulates	phenotype	0.95
Mechanical Force Transduction	mediates	process	0.95
Tumor Progression	involved_in	process	0.95
mechanical stimuli	associated_with	process	0.95
Lymphatic Malformations	causes	disease	0.95
Tumor Angiogenesis	promotes	process	0.95
tumour progression	promotes	process	0.95
Central Nervous System Physiology	regulates	process	0.95
Tumor Cell Invasion	regulates	process	0.95
Stiffness Sensing	mediates	process	0.95
Uterine Contractions	mediates	phenotype	0.95
Mechanical Forces	involved_in	process	0.92
Tissue Stiffness	mediates	phenotype	0.92
liver fibrosis	therapeutic_target	disease	0.92
Liver Fibrosis	protects_against	disease	0.92
parturition	mediates	process	0.92
gastric cancer	therapeutic_target	disease	0.90
Periodontal Ligament Cell	expressed_in	cell_type	0.90
tumour cell proliferation	regulates	process	0.90
Central Nervous System	associated_with	anatomical_entity	0.90
tumour angiogenesis	promotes	process	0.90
tumour cell migration	regulates	process	0.90
macrophage	modulates	cell	0.90
liver fibrosis	suppresses	disease	0.90
tumour cell invasion	regulates	process	0.90
Tumor Immune Escape	contributes_to	process	0.90
Cell Cycle Progression	regulates	process	0.90
Extracellular Matrix Remodeling	associated_with	process	0.90

Incoming (261)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PIEZO1	data_in	dataset_row	0.00
PIEZO1	encodes	gene	0.00
Paeoniflorin	binds	compound	0.95
Mechanical Stimulation	activates	mechanism	0.95
NF-κB	upstream_of	pathway	0.95
Paeoniflorin	therapeutic_target	compound	0.93
TNF	upregulates	entity	0.90
Mechanical Stretch	activates	process	0.90
ECM stiffness	activates	phenotype	0.90
Tissue Stiffness	activates	phenotype	0.90
tissue stiffness	activates	phenotype	0.90
h-725c62e9	targets	hypothesis	0.90
mechanical loading	activates	phenotype	0.90
mechanical stiffness	activates	phenotype	0.90
CREB1	regulates	protein	0.90
IL1A	activates	protein	0.90
Tissue Stiffening	upregulates	process	0.90
artemisinin	inhibits	drug	0.90
ATF2	regulates	protein	0.80
HNF4	regulates	protein	0.80
diabetic kidney disease	activates	disease	0.80
h-db6aa4b1	targets	hypothesis	0.80
FAM38A	encodes	gene	0.80
p38 MAPK	regulates	protein	0.80
Ecm Stiffness	activates	pathway	0.80
Inflammation	modulates	process	0.75
soluble signals	modulates	process	0.75
Yoda1	activates	drug	0.72
MECHANICAL_STIMULATION	activates	phenotype	0.72
RUNX2	activates	gene	0.70
cerebral ischemia/reperfusion injury	activates	process	0.70
mechanical stress	activates	process	0.70
high fat diet	activates	phenotype	0.70
BAX	activates	gene	0.70
cyclical_hydrostatic_pressure	activates	phenotype	0.64
KCNK2	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
FGF1	activates	gene	0.60
KCNQ1	associated_with	gene	0.60
EGFR	activates	gene	0.60
P38	activates	gene	0.60
ANG	activates	gene	0.60
PIEZO2	regulates	gene	0.60
TGFBR2	inhibits	gene	0.60
TRPV4	expressed_in	gene	0.60
FGFR1	regulates	gene	0.60
OVERVIEW	inhibits	gene	0.60
KCNK2	expressed_in	gene	0.60
CFTR	associated_with	gene	0.60
PIEZO2	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Extracellular Matrix Stiffness Modulation	0.691	neurodegeneration	Microglia-astrocyte crosstalk amplificat
Piezo1 Channel Inhibition Prevents Mechanical Amplification	0.000	-	Microglia-astrocyte crosstalk amplificat

Mentioning Analyses (5)

Scientific analyses that reference this entity

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Microglial activation by bEVs via Piezo1	exploratory	Alzheimer's disease	0.900	0.00	microglia (in vivo and in vitr	proposed	N/A
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$240,000
Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe	clinical	Neurodegeneration	0.400	0.50	in_silico	proposed	$200,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Brain Capillary Ion Channels: Physiology and Channelopathies. [PMID:40748720]	Harraz OF, Hashad AM	Physiology (Bethesda)	2026	1
Stiffness sensing via Piezo1 enhances macrophage efferocytosis and promotes the [PMID:38838160]	Wang Y, Wang J, Zhang J, Wang Y, Wang Y,	Sci Adv	2024	1
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central [PMID:37532007]	Zong B, Yu F, Zhang X, Pang Y, Zhao W, S	Ageing Res Rev	2023	1
Targeting extracellular matrix stiffness and mechanotransducers to improve cance [PMID:35331296]	Jiang Y, Zhang H, Wang J, Liu Y, Luo T,	J Hematol Oncol	2022	1
Mechanically activated ion channel Piezo1 modulates macrophage polarization and [PMID:34059671]	Atcha H, Jairaman A, Holt JR, Meli VS, N	Nat Commun	2021	1
Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT [PMID:41175920]	Sun H, Wu Z, Zhang Y, Liu C, Gao D et al	Osteoarthritis Cartilage	2026	0
Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolis [PMID:41486513]	Ma J, Xie N, Wang Z, Liang X, Han Y et a	Adv Sci (Weinh)	2026	0
Insights into the role of the mechanosensitive Piezo1 channel and signaling mech [PMID:41544798]	Zhang M, Ge Y, Wang Z, Li H, Wang G et a	Neurosci Biobehav Rev	2026	0
Long-range chemical signalling in vivo is regulated by mechanical signals. [PMID:41555045]	Pillai EK, Mukherjee S, Gampl N, McGinn	Nat Mater	2026	0
The Glymphatic System and Meningeal Lymphatics: Current Understandings and Futur [PMID:41930354]	Sun H, Fan H, Zhou Y, Zhu H, Chen Y et a	MedComm (2020)	2026	0
Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic [PMID:40653265]	["Li R", "Xia J", "Shi C", "Zhang K", "Q	Journal of advanced research	2026	0
Piezo1 is a pathogenic gene and therapeutic target for neurological diseases. [PMID:40276938]	Wang H, Gou Z, Chen S, Lu L	The International journal of n	2026	0
Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and em [PMID:41195420]	Liu Y, Xu YQ, Long YY, Xiao H, Ma YY, Li	Frontiers in molecular bioscie	2025	0
PIEZO1: a mechanosensitive ion channel in the pathogenesis and pharmacotherapy o [PMID:41051683]	Gupta T, Singh TG, Singh R	Molecular biology reports	2025	0
Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion [PMID:38744281]	Zhang J, Li J, Hou Y, Lin Y, Zhao H, Shi	Cell	2024	0
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing nov [PMID:35236990]	["Costello S", "Shoemaker S", "Hobbs H",	Nature structural & molecular	2022	0
Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hep [PMID:36181398]	Li M, Zhang X, Wang M, Wang Y, Qian J, X	Cancer communications (London,	2022	0
A process-based approach to understanding and managing triggered seismicity. [PMID:34321668]	["Hager B", "Dieterich J", "Frohlich C",	Nature	2021	0
Searching for female reproductive aging and longevity biomarkers. [PMID:34156973]	["Yureneva S", "Averkova V", "Silachev D	Aging	2021	0
ANCA associated vasculitis. [PMID:32291255]	Robert W Hunter; Nicola Welsh; Tariq E F	BMJ (Clinical research ed.)	2020	0

Debates (20)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning PIEZO1 in their description or question text

No additional research found

PIEZO1

Understanding Entity Pages

Summary

Wiki Pages (1)

PIEZO1 — Piezo Type Mechanosensitive Ion Channel Component 1

Pathway Diagram

Outgoing (717)

Incoming (261)

Targeting Hypotheses (2)

Mentioning Analyses (5)

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

Circuit-level neural dynamics in neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Experiments (3)

Related Papers (20)

Debates (20)

Structured research brief for hypothesis h-var-b7e4505525: Closed-loop transcran

Extended debate: Closed-loop transcranial focused ultrasound with 40Hz gamma ent

Extended debate: Closed-loop tACS targeting EC-II SST interneurons to block tau

Debate: Closed-loop transcranial focused ultrasound targeting entorhinal PV inte

Debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagati

Debate: Closed-loop transcranial focused ultrasound to restore hippocampal gamma

Debate: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firin

Debate: Closed-loop tACS targeting EC-II somatostatin interneurons to restore de

Debate: Closed-loop transcranial focused ultrasound with real-time gamma feedbac

Hypothesis debate: Closed-loop transcranial alternating current stimulation to r

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