gene

PIEZO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIEZO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1011Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

3Experiments

2Debates

Summary

PIEZO1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 510 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PIEZO1
Full Name	Piezo Type Mechanosensitive Ion Channel Component 1
Chromosome	16q24.3
Protein Type	Ion Channel
Target Class	Ion Channel
Function	Small molecule modulator of mechanosensitive ion channel activity
Mechanism of Action	Small molecule modulator of mechanosensitive ion channel activity
Primary Expression	microglia, astrocytes, and brain endothelial cells, where it transduces mechanical cues from the ti
Druggability	Low (0.42)
Clinical Stage	Phase I
Molecular Weight	286 kDa
Amino Acids	521 aa
Exons	51
Pathways	Angiogenesis, Apoptosis, Autophagy, Calcium Signaling, Epigenetic
UniProt ID	Q9H5I5
NCBI Gene ID	9780
Ensembl ID	ENSG00000103335
OMIM	611184
GeneCards	PIEZO1
Human Protein Atlas	PIEZO1
Associated Diseases	Als, Alzheimer, Atherosclerosis, Bacterial Infection, calcium influx, Cancer
Known Drugs/Compounds	artemisinin, Paeoniflorin, Yoda1
Interactions	Actin, ADAMTS5, AGING, AKT, ALS, ALZHEIMER'S DISEASE
SciDEX Target	View Target Profile (5 clinical trials)
SciDEX Hypotheses	Extracellular Matrix Stiffness Modulation
KG Connections	960 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — PIEZO1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

5Z10 — X-ray / Cryo-EM

🔮 AI Predicted Structure

Q9H5I5 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PIEZO1 — Piezo Type Mechanosensitive Ion Channel Component 1

gene · 1444 words

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Pathway Diagram

graph TD
    PIEZO1["PIEZO1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    PIEZO1["PIEZO1"] -->|"interacts"| KCNK2["KCNK2"]
    PIEZO1["PIEZO1"] -->|"co discussed"| P2RX7["P2RX7"]
    PIEZO1["PIEZO1"] -->|"co discussed"| DGAT1["DGAT1"]
    PIEZO1["PIEZO1"] -->|"co discussed"| C3["C3"]
    PIEZO1["PIEZO1"] -->|"co discussed"| GABRA1["GABRA1"]
    KCNK2_1["KCNK2"] -->|"interacts"| PIEZO1["PIEZO1"]
    BMAL1["BMAL1"] -->|"co discussed"| PIEZO1["PIEZO1"]
    HK2["HK2"] -->|"co discussed"| PIEZO1["PIEZO1"]
    MIRO1["MIRO1"] -->|"co discussed"| PIEZO1["PIEZO1"]
    style PIEZO1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (742)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PIEZO1	data_in	dataset_row	0.00
TMEM16F	interacts_with	gene	1.00
Als	activates	disease	1.00
Tumor Cell Invasion	regulates	process	0.95
Ca2+ influx	mediates	process	0.95
Tumor Cell Proliferation	regulates	process	0.95
Tumor Progression	involved_in	process	0.95
Tumor Angiogenesis	promotes	process	0.95
mechanical stimuli	associated_with	process	0.95
tumour progression	promotes	process	0.95
Tumor Cell Migration	regulates	process	0.95
mechanosensing	mediates	process	0.95
uterine contractions	associated_with	phenotype	0.95
Stiffness Sensing	mediates	process	0.95
Uterine Contractions	mediates	phenotype	0.95
Macrophage Efferocytosis	associated_with	process	0.95
Central Nervous System Physiology	regulates	process	0.95
Efferocytosis	activates	process	0.95
Stiffness Sensing	modulates	process	0.95
Parturition	involved_in	process	0.95
Macrophage Efferocytosis	promotes	process	0.95
Mechanical Force Transduction	mediates	process	0.95
Liver Fibrosis Resolution	promotes	phenotype	0.95
Bone Mass	regulates	phenotype	0.95
Macrophage Efferocytosis	activates	process	0.95
Central Nervous System	involved_in	process	0.95
Uterine Contractions	involved_in	phenotype	0.95
Muscle Mass	regulates	phenotype	0.95
Hepatic Fibrosis	upregulates	disease	0.95
Lymphatic Malformations	causes	disease	0.95
Macrophage Polarization	modulates	process	0.95
Lymphatic Endothelial Cells	expressed_in	cell_type	0.95
Renal Fibrosis	implicated_in	disease	0.95
Mechanical Forces	involved_in	process	0.92
Tissue Stiffness	mediates	phenotype	0.92
Liver Fibrosis	protects_against	disease	0.92
parturition	mediates	process	0.92
liver fibrosis	therapeutic_target	disease	0.92
Liver Fibrosis	associated_with	disease	0.90
Cell Cycle Progression	regulates	process	0.90
Lymphatic Sprouting	mediates	process	0.90
bone formation	activates	phenotype	0.90
Efferocytosis	associated_with	biological_process	0.90
Liver Fibrosis	involved_in	disease	0.90
Tissue Stiffness Sensing	mediates	process	0.90
Mechanical Forces	mediates	process	0.90
Apoptotic Cell Clearance	regulates	process	0.90
Mechanobiology	mediates	process	0.90
Periodontal Ligament Cell	expressed_in	cell_type	0.90
Inflammation Resolution	promotes	process	0.90

Incoming (269)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PIEZO1	data_in	dataset_row	0.00
Paeoniflorin	binds	compound	0.95
Mechanical Stimulation	activates	mechanism	0.95
NF-κB	upstream_of	pathway	0.95
Paeoniflorin	therapeutic_target	compound	0.93
Mechanical Stretch	activates	process	0.90
h-725c62e9	targets_gene	hypothesis	0.90
CREB1	regulates	protein	0.90
mechanical loading	activates	phenotype	0.90
TNF	upregulates	entity	0.90
tissue stiffness	activates	phenotype	0.90
IL1A	activates	protein	0.90
artemisinin	inhibits	drug	0.90
Tissue Stiffness	activates	phenotype	0.90
ECM stiffness	activates	phenotype	0.90
mechanical stiffness	activates	phenotype	0.90
Tissue Stiffening	upregulates	process	0.90
h-725c62e9	targets	hypothesis	0.80
h-db6aa4b1	targets	hypothesis	0.80
FAM38A	encodes	gene	0.80
HNF4	regulates	protein	0.80
diabetic kidney disease	activates	disease	0.80
ATF2	regulates	protein	0.80
Ecm Stiffness	activates	pathway	0.80
p38 MAPK	regulates	protein	0.80
soluble signals	modulates	process	0.75
Inflammation	modulates	process	0.75
Yoda1	activates	drug	0.72
MECHANICAL_STIMULATION	activates	phenotype	0.72
high fat diet	activates	phenotype	0.70
mechanical stress	activates	process	0.70
RUNX2	activates	gene	0.70
cerebral ischemia/reperfusion injury	activates	process	0.70
BAX	activates	gene	0.70
cyclical_hydrostatic_pressure	activates	phenotype	0.64
KCNK2	co_mentioned_with	gene	0.60
CANCER	associated_with	gene	0.60
TRPA1	causes	gene	0.60
MAPK	activates	gene	0.60
AND	inhibits	gene	0.60
IL-6	activates	gene	0.60
AND	regulates	gene	0.60
ROS	regulates	gene	0.60
AMYLOID	activates	gene	0.60
ROS	inhibits	gene	0.60
GLAUCOMA	associated_with	entity	0.60
CANCER	activates	entity	0.60
ALZHEIMER	regulates	gene	0.60
CACNA1B	causes	gene	0.60
GENETIC MUTATIONS	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Extracellular Matrix Stiffness Modulation	0.691	neurodegeneration	Microglia-astrocyte crosstalk amplificat

Mentioning Analyses (2)

Scientific analyses that reference this entity

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.729

Astrocyte reactivity subtypes in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.741

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Microglial activation by bEVs via Piezo1	exploratory	Alzheimer's disease	0.900	0.00	microglia (in vivo and in vitr	proposed	N/A
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$240,000
Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe	clinical	Neurodegeneration	0.400	0.50	in_silico	proposed	$200,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Brain Capillary Ion Channels: Physiology and Channelopathies. [PMID:40748720]	Harraz OF, Hashad AM	Physiology (Bethesda)	2026	1
Stiffness sensing via Piezo1 enhances macrophage efferocytosis and promotes the [PMID:38838160]	Wang Y, Wang J, Zhang J, Wang Y, Wang Y,	Sci Adv	2024	1
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central [PMID:37532007]	Zong B, Yu F, Zhang X, Pang Y, Zhao W, S	Ageing Res Rev	2023	1
Targeting extracellular matrix stiffness and mechanotransducers to improve cance [PMID:35331296]	Jiang Y, Zhang H, Wang J, Liu Y, Luo T,	J Hematol Oncol	2022	1
Mechanically activated ion channel Piezo1 modulates macrophage polarization and [PMID:34059671]	Atcha H, Jairaman A, Holt JR, Meli VS, N	Nat Commun	2021	1
Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT [PMID:41175920]	Sun H, Wu Z, Zhang Y, Liu C, Gao D et al	Osteoarthritis Cartilage	2026	0
Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolis [PMID:41486513]	Ma J, Xie N, Wang Z, Liang X, Han Y et a	Adv Sci (Weinh)	2026	0
Insights into the role of the mechanosensitive Piezo1 channel and signaling mech [PMID:41544798]	Zhang M, Ge Y, Wang Z, Li H, Wang G et a	Neurosci Biobehav Rev	2026	0
Long-range chemical signalling in vivo is regulated by mechanical signals. [PMID:41555045]	Pillai EK, Mukherjee S, Gampl N, McGinn	Nat Mater	2026	0
The Glymphatic System and Meningeal Lymphatics: Current Understandings and Futur [PMID:41930354]	Sun H, Fan H, Zhou Y, Zhu H, Chen Y et a	MedComm (2020)	2026	0
Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic [PMID:40653265]	["Li R", "Xia J", "Shi C", "Zhang K", "Q	Journal of advanced research	2026	0
Piezo1 is a pathogenic gene and therapeutic target for neurological diseases. [PMID:40276938]	Wang H, Gou Z, Chen S, Lu L	The International journal of n	2026	0
Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and em [PMID:41195420]	Liu Y, Xu YQ, Long YY, Xiao H, Ma YY, Li	Frontiers in molecular bioscie	2025	0
PIEZO1: a mechanosensitive ion channel in the pathogenesis and pharmacotherapy o [PMID:41051683]	Gupta T, Singh TG, Singh R	Molecular biology reports	2025	0
Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion [PMID:38744281]	Zhang J, Li J, Hou Y, Lin Y, Zhao H, Shi	Cell	2024	0
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing nov [PMID:35236990]	["Costello S", "Shoemaker S", "Hobbs H",	Nature structural & molecular	2022	0
Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hep [PMID:36181398]	Li M, Zhang X, Wang M, Wang Y, Qian J, X	Cancer communications (London,	2022	0
A process-based approach to understanding and managing triggered seismicity. [PMID:34321668]	["Hager B", "Dieterich J", "Frohlich C",	Nature	2021	0
Searching for female reproductive aging and longevity biomarkers. [PMID:34156973]	["Yureneva S", "Averkova V", "Silachev D	Aging	2021	0
ANCA associated vasculitis. [PMID:32291255]	Robert W Hunter; Nicola Welsh; Tariq E F	BMJ (Clinical research ed.)	2020	0

Debates (2)

Multi-agent debates referencing this entity

Astrocyte reactivity subtypes in neurodegeneration

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

closed · Rounds: 4 · Score: 0.90 · 2026-04-06