Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MICROTUBULE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MICROTUBULE |
flowchart TD
N0["MICROTUBULE"]
N1["TAU"]
N1 -->|"binds to"| N0
N2["MAP6"]
N2 -->|"binds to"| N0
N3["LIS1"]
N3 -->|"interacts with"| N0
N4["DOUBLECORTIN"]
N4 -->|"interacts with"| N0
N5["NEURON"]
N5 -->|"regulates"| N0
N0 -->|"involved in"| N5
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
class N0 concept
class N1 entity
class N2 entity
class N3 entity
class N4 entity
class N5 cell_type| Target | Relation | Type | Str |
|---|---|---|---|
| neuron development | involved_in | process | 0.95 |
| organelle transport | involved_in | process | 0.95 |
| NEURON | involved_in | entity | 0.95 |
| axon elongation | mediates | process | 0.90 |
| dendrite elongation | mediates | process | 0.90 |
| neurite outgrowth | involved_in | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TAU | binds_to | entity | 0.95 |
| MAP6 | binds_to | entity | 0.95 |
| TAU | regulates | entity | 0.95 |
| MAP6 | regulates | entity | 0.95 |
| TAU | interacts_with | protein | 0.95 |
| MAPT | binds | protein | 0.95 |
| MAPT | associated_with | protein | 0.95 |
| MAPT | interacts_with | gene | 0.95 |
| MAP6 | interacts_with | gene | 0.95 |
| MAPT | regulates | protein | 0.95 |
| MAP6 | associated_with | protein | 0.95 |
| LIS1 | interacts_with | entity | 0.90 |
| DOUBLECORTIN | interacts_with | entity | 0.90 |
| MAP1B | associated_with | protein | 0.90 |
| MAP2 | associated_with | protein | 0.90 |
| MYOM1 | mediates | protein | 0.85 |
| CRMP1 | binds | protein | 0.85 |
| Tauopathy | causes | process | 0.85 |
| Exomeres | associated_with | structure | 0.80 |
| actin | interacts_with | protein | 0.75 |
| Tau | interacts_with | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Tau/MAP6 ratio as a master switch for microtubule dynamics p | 0.750 | neurodegeneration | View |
| HDAC6 Selective Inhibition to Restore Acetylation Balance an | 0.643 | structural biology | What is the atomic-resolution structure |
| Tau-Independent Microtubule Stabilization via MAP6 Enhanceme | 0.567 | neurodegeneration | Selective vulnerability of entorhinal co |
| MAP6-mediated microtubule stabilization as therapeutic targe | 0.500 | neurodegeneration | View |
| Kinesin-Dependent Peripheral Microtubule Transport Maintains | 0.486 | neurodegeneration | What determines the spatial organization |
| HDAC6 Inhibition for Dual Restoration of Microtubule Stabili | 0.484 | neurodegeneration | Which tau PTMs are both disease-specific |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| MAP6 depletion effects on neuronal development in primary cultures | exploratory | 0.900 | 0.00 | primary rodent neuronal cultur | proposed | N/A | |
| MAP6 depletion effects on neuronal development in primary cultures | exploratory | 0.900 | 0.00 | primary rodent neuronal cultur | proposed | N/A | |
| In vivo neuronal migration assay with MAP6 depletion | validation | 0.850 | 0.00 | rodent in vivo model | proposed | N/A | |
| 4R-Tau Targeting Therapies for PSP and CBS | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Anti-Tau Immunotherapy Dosing Optimization | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy in 4R-Tau | validation | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $170,000 |
| Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Trials Have N | clinical | ALS | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Axonal Transport Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Blood Biomarker vs Tau PET for Treatment Monitoring | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omics Study | validation | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $160,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Tau and MAP6 establish labile and stable domains on microtubules. [PMID:40040809] | Kirimtay K, Huang W, Sun X, Qiang L, Wan | iScience | 2025 | 1 |
| Antagonistic roles of tau and MAP6 in regulating neuronal development. [PMID:39257379] | Sun X, Yu W, Baas PW, Toyooka K, Qiang L | J Cell Sci | 2024 | 1 |
| Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Storie [PMID:34025352] | Cuveillier C, Boulan B, Ravanello C, Den | Front Mol Neurosci | 2021 | 1 |
| Tau: It's Not What You Think. [PMID:30929793] | Baas PW, Qiang L | Trends Cell Biol | 2019 | 1 |
| Stability properties of neuronal microtubules. [PMID:26887570] | Baas PW, Rao AN, Matamoros AJ, Leo L | Cytoskeleton (Hoboken) | 2016 | 1 |
| Targeting CXCL16-expressing macrophages with a biomimetic nanocarrier system att [PMID:41707770] | Yang Q, Xu Y, Zhan Y, Li J, Peng R, Yu B | Journal of controlled release | 2026 | 0 |
| The MAP6-NTS axis in hippocampal CA1 regulates synaptic plasticity and memory. [PMID:41825505] | Jia Y, Lei J, Jiang Y, Xue L, Chen T, Wa | Neuropharmacology | 2026 | 0 |
| BioID2-Based Tau Interactome Reveals Novel and Known Protein Interactions Associ [PMID:40910579] | Atwa A, Alhadidy MM, Lamp J, Combs B, Ka | Journal of proteome research | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| ReMAPping the microtubule landscape: How phosphorylation dictates the activities [PMID:28980356] | Ramkumar A, Jong BY, Ori-McKenney KM | Developmental dynamics : an of | 2018 | 0 |
| Inferring patterns of folktale diffusion using genomic data. [PMID:28784786] | ["Bortolini E", "Pagani L", "Crema E", " | Proceedings of the National Ac | 2017 | 0 |
| Purification and Characterization of Progenitor and Mature Human Astrocytes Reve [PMID:26687838] | ["Zhang Y", "Sloan S", "Clarke L", "Cane | Neuron | 2016 | 0 |
| Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severin [PMID:24065130] | ["Zempel H", "Luedtke J", "Kumar Y", "Bi | The EMBO journal | 2013 | 0 |
| Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). [PMID:21902667] | Gozes I | Current pharmaceutical design | 2011 | 0 |
| Decreased neuroautonomic complexity in men during an acute major depressive epis [PMID:22832529] | ["Leistedt S", "Linkowski P", "Lanquart | Translational psychiatry | 2011 | 0 |
| Bidirectional activity-dependent plasticity at corticostriatal synapses. [PMID:16339023] | ["Fino E", "Glowinski J", "Venance L"] | The Journal of neuroscience : | 2005 | 0 |
| STOP proteins. [PMID:14567673] | Bosc C, Andrieux A, Job D | Biochemistry | 2003 | 0 |
| Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hy [PMID:12070343] | ["Zhao R", "Masayasu H", "Holmgren A"] | Proceedings of the National Ac | 2002 | 0 |
| STOP proteins. [PMID:15218867] | Bosc C, Oenarier E, Andrieux A, Job D | Cell structure and function | 1999 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MICROTUBULE in their description or question text