concept

MICROTUBULE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MICROTUBULE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections
6Hypotheses
0Analyses
6Outgoing
21Incoming
10Experiments
0Debates

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💡 Concept Info
NameMICROTUBULE

Pathway Diagram

flowchart TD
    N0["MICROTUBULE"]
    N1["TAU"]
    N1 -->|"binds to"| N0
    N2["MAP6"]
    N2 -->|"binds to"| N0
    N3["LIS1"]
    N3 -->|"interacts with"| N0
    N4["DOUBLECORTIN"]
    N4 -->|"interacts with"| N0
    N5["NEURON"]
    N5 -->|"regulates"| N0
    N0 -->|"involved in"| N5

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 concept
    class N1 entity
    class N2 entity
    class N3 entity
    class N4 entity
    class N5 cell_type

Outgoing (6)

TargetRelationTypeStr
neuron developmentinvolved_inprocess0.95
organelle transportinvolved_inprocess0.95
NEURONinvolved_inentity0.95
axon elongationmediatesprocess0.90
dendrite elongationmediatesprocess0.90

Incoming (21)

SourceRelationTypeStr
TAUbinds_toentity0.95
MAP6binds_toentity0.95
TAUregulatesentity0.95
MAP6regulatesentity0.95
TAUinteracts_withprotein0.95

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Tau/MAP6 ratio as a master switch for microtubule dynamics p 0.750 neurodegeneration View
HDAC6 Selective Inhibition to Restore Acetylation Balance an 0.643 structural biology What is the atomic-resolution structure
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme 0.567 neurodegeneration Selective vulnerability of entorhinal co
MAP6-mediated microtubule stabilization as therapeutic targe 0.500 neurodegeneration View
Kinesin-Dependent Peripheral Microtubule Transport Maintains 0.486 neurodegeneration What determines the spatial organization
HDAC6 Inhibition for Dual Restoration of Microtubule Stabili 0.484 neurodegeneration Which tau PTMs are both disease-specific

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
MAP6 depletion effects on neuronal development in primary cultures exploratory 0.900 0.00 primary rodent neuronal cultur proposed N/A
MAP6 depletion effects on neuronal development in primary cultures exploratory 0.900 0.00 primary rodent neuronal cultur proposed N/A
In vivo neuronal migration assay with MAP6 depletion validation 0.850 0.00 rodent in vivo model proposed N/A
4R-Tau Targeting Therapies for PSP and CBS clinical Alzheimer's Disease 0.400 0.50 human proposed $6,550,000
Anti-Tau Immunotherapy Dosing Optimization clinical Alzheimer's Disease 0.400 0.50 human proposed $5,460,000
Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy in 4R-Tau validation Neurodegeneration 0.400 0.50 cell_line proposed $170,000
Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Trials Have N clinical ALS 0.400 0.50 human proposed $7,500,000
Axonal Transport Dysfunction Validation in Parkinson's Disease clinical Parkinson's Disease 0.400 0.50 human proposed $6,550,000
Blood Biomarker vs Tau PET for Treatment Monitoring clinical ALS 0.400 0.50 human proposed $5,460,000
CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omics Study validation Neurodegeneration 0.400 0.50 cell_line proposed $160,000

Related Papers (19)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Tau and MAP6 establish labile and stable domains on microtubules. [PMID:40040809] Kirimtay K, Huang W, Sun X, Qiang L, Wan iScience 2025 1
Antagonistic roles of tau and MAP6 in regulating neuronal development. [PMID:39257379] Sun X, Yu W, Baas PW, Toyooka K, Qiang L J Cell Sci 2024 1
Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Storie [PMID:34025352] Cuveillier C, Boulan B, Ravanello C, Den Front Mol Neurosci 2021 1
Tau: It's Not What You Think. [PMID:30929793] Baas PW, Qiang L Trends Cell Biol 2019 1
Stability properties of neuronal microtubules. [PMID:26887570] Baas PW, Rao AN, Matamoros AJ, Leo L Cytoskeleton (Hoboken) 2016 1
Targeting CXCL16-expressing macrophages with a biomimetic nanocarrier system att [PMID:41707770] Yang Q, Xu Y, Zhan Y, Li J, Peng R, Yu B Journal of controlled release 2026 0
The MAP6-NTS axis in hippocampal CA1 regulates synaptic plasticity and memory. [PMID:41825505] Jia Y, Lei J, Jiang Y, Xue L, Chen T, Wa Neuropharmacology 2026 0
BioID2-Based Tau Interactome Reveals Novel and Known Protein Interactions Associ [PMID:40910579] Atwa A, Alhadidy MM, Lamp J, Combs B, Ka Journal of proteome research 2025 0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] ["Sanadgol N", "Abedi M", "Hashemzaei M" Journal of nanobiotechnology 2025 0
ReMAPping the microtubule landscape: How phosphorylation dictates the activities [PMID:28980356] Ramkumar A, Jong BY, Ori-McKenney KM Developmental dynamics : an of 2018 0
Inferring patterns of folktale diffusion using genomic data. [PMID:28784786] ["Bortolini E", "Pagani L", "Crema E", " Proceedings of the National Ac 2017 0
Purification and Characterization of Progenitor and Mature Human Astrocytes Reve [PMID:26687838] ["Zhang Y", "Sloan S", "Clarke L", "Cane Neuron 2016 0
Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severin [PMID:24065130] ["Zempel H", "Luedtke J", "Kumar Y", "Bi The EMBO journal 2013 0
Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). [PMID:21902667] Gozes I Current pharmaceutical design 2011 0
Decreased neuroautonomic complexity in men during an acute major depressive epis [PMID:22832529] ["Leistedt S", "Linkowski P", "Lanquart Translational psychiatry 2011 0
Bidirectional activity-dependent plasticity at corticostriatal synapses. [PMID:16339023] ["Fino E", "Glowinski J", "Venance L"] The Journal of neuroscience : 2005 0
STOP proteins. [PMID:14567673] Bosc C, Andrieux A, Job D Biochemistry 2003 0
Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hy [PMID:12070343] ["Zhao R", "Masayasu H", "Holmgren A"] Proceedings of the National Ac 2002 0
STOP proteins. [PMID:15218867] Bosc C, Oenarier E, Andrieux A, Job D Cell structure and function 1999 0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MICROTUBULE in their description or question text

HDAC6 Inhibition for Dual Restoration of Microtubule Stability and Autophagic Ta

Score: 0.484 · neurodegeneration · 2026-04-13

## Mechanistic Overview HDAC6 Inhibition for Dual Restoration of Microtubule Stability and Autophagic Tau Clearance star