| Gene Symbol | NYAP1 |
| Function | NYAP1 participates in critical neuronal signaling pathways: |
| Primary Expression | the brain and plays important roles in neuronal migration, synaptic plasticity, and neuronal survival |
| Subcellular Localization | </th><td>Cytoplasm, Membrane</td></tr> |
| Molecular Weight | 42 kDa |
| Amino Acids | 380 aa |
| Pathways | PI3K, PI3K Signaling |
| GeneCards | NYAP1 |
| Human Protein Atlas | NYAP1 |
| N-Terminal Domain | Contains multiple tyrosine residues that are phosphorylated |
| Central Region | Proline-rich region for protein-protein interactions |
| C-Terminal Domain | Conserved region for PI3K binding |
| Neuronal Survival | PI3K/Akt signaling is neuroprotective; NYAP1 variants may impair this pathway |
| Synaptic Plasticity | Dysregulation may contribute to synaptic dysfunction in AD |
| [Tau](/proteins/tau) Phosphorylation | Akt regulates tau phosphorylation; NYAP1 variants may affect this pathway |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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