gene 1,339 words KG: YAP1
Contents

YAP1 — Yes-Associated Protein 1

🧬 Gene Info
Gene SymbolYAP1
Full NameYes-Associated Protein 1
Chromosome11q22.1.
FunctionNeural development: YAP1 is essential for neural progenitor cell proliferation and maintenance of the neural stem cell pool during cortical development.
Primary ExpressionHippocampus, Cortex, Cerebellum, Substantia nigra (widespread)
Molecular Weight54 kDa
Exons9
PathwaysWnt, TGF-β, Notch
UniProt IDP46937
NCBI Gene ID10413
Ensembl IDENSG00000137693
OMIM606608
GeneCardsYAP1
Human Protein AtlasYAP1
TEAD-responsive elementsYAP1 expression is partially auto-regulated through TEAD-dependent transcription
Associated DiseasesAls, Cancer, Carcinoma, Tumor
InteractionsABCA1, Actin, AKT, ALS, AMPK, AND
KG Connections192 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Extracellular Matrix Stiffness Modulation
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (8)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed

Related Experiments (2)

Silibinin-induced G2/M cell cycle arrest in breast cancer ce
exploratory · proposed · Score: 0.90
Direct targeting of Capza1 by silibinin
exploratory · proposed · Score: 0.85

See Also (15)

Astrocytes
cell · KG edge: expressed_in
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: inhibits
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: activates
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

PTEN activates YAP1
YAP1 activates LOX
SPP1 associated_with YAP1
LOX activates YAP1
YAP1 activates PTEN
YAP1 activates GBM
TP53 therapeutic_target YAP1
YAP1 activates MYC
YAP1 activates MET
YAP1 therapeutic_target RB1

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