pathway

Hippo Pathway

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Hippo Pathway: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

171Connections

0Hypotheses

0Analyses

15Outgoing

50Incoming

0Experiments

0Debates

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🔀 Pathway Info

Name	Hippo Pathway
Key Genes/Proteins	Actin, AGING, AKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE
Related Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis

Wiki Pages (2)

Knowledge base pages for this entity

LATS1 — Large Tumor Suppressor Kinase 1, Hippo Pathway

gene · 1653 words

→

Hippo Pathway in Neurodegeneration

mechanism · 1441 words

→

Pathway Diagram

graph TD
    HIPPO["HIPPO"] -->|"regulates"| Hippo_Pathway["Hippo Pathway"]
    CANCER["CANCER"] -->|"therapeutic target"| Hippo_Pathway["Hippo Pathway"]
    Cancer["Cancer"] -->|"therapeutic target"| Hippo_Pathway["Hippo Pathway"]
    HIPPO_1["HIPPO"] -->|"associated"| Hippo_Pathway["Hippo Pathway"]
    style Hippo_Pathway fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
TAZ	regulates	protein	0.90
tissue growth	regulates	phenotype	0.90
cell proliferation	regulates	phenotype	0.90
YAP	regulates	protein	0.90
Breast Cell Fate	regulates	process	0.90
ESR1	interacts_with	gene	0.90
neuroinflammation	modulates	process	0.75
cell apoptosis	regulates	process	0.70
IL6	regulates	protein	0.70
Neuron	regulates	cell_type	0.50
CELL MIGRATION	activates	concept	0.50
Fibroblast	activates	cell_type	0.50
APOPTOSIS	associated_with	phenotype	0.45
AKT	associated_with	gene	0.45
EGFR	associated_with	gene	0.45

Incoming (156)

Source	Relation	Type	Str
HIPPO	regulates	gene	1.00
CANCER	regulates	gene	0.70
Cancer	regulates	disease	0.70
Cancer	therapeutic_target	disease	0.70
CANCER	therapeutic_target	gene	0.70
APOPTOSIS	regulates	gene	0.70
AKT	regulates	gene	0.70
PI3K	regulates	gene	0.70
HIPPO	therapeutic_target	gene	0.70
HIPPO	associated_with	gene	0.70
Als	therapeutic_target	disease	0.70
YAP	associated_with	gene	0.70
EGFR	causes	gene	0.65
Tumor	activates	disease	0.65
TAZ	regulates	gene	0.60
YAP	regulates	gene	0.60
LATS1	regulates	gene	0.60
LIF	activates	gene	0.60
EGFR	activates	gene	0.60
Pancreatic Cancer	associated_with	disease	0.60
APOPTOSIS	implicated_in	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	implicated_in	gene	0.60
NEURODEGENERATIVE DISORDERS	implicated_in	gene	0.60
Neurodegeneration	therapeutic_target	disease	0.60
MST1	therapeutic_target	gene	0.60
QKI	therapeutic_target	gene	0.60
NCL	therapeutic_target	gene	0.60
DDB1	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
TAZ	associated_with	gene	0.60
KRAS	associated_with	gene	0.60
RAS	associated_with	gene	0.60
MYC	activates	gene	0.60
Carcinoma	activates	disease	0.60
Hepatocellular Carcinoma	activates	disease	0.60
ERK1	regulates	gene	0.60
Breast Cancer	regulates	disease	0.60
Als	regulates	disease	0.60
NEURODEGENERATION	treats	gene	0.60
FOXO1	regulates	gene	0.60
STAT3	treats	gene	0.60
PI3K	treats	gene	0.60
HIF	regulates	gene	0.60
IL-6	regulates	gene	0.60
P38	treats	gene	0.60
INFLAMMATION	treats	gene	0.60
CANCER	treats	gene	0.60
JAK	regulates	gene	0.60
Cardiovascular	treats	disease	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning Hippo Pathway in their description or question text

No additional research found