| Gene Symbol | NYAP1 |
| Full Name | Neuronal Tyrosine-Phosphorylated Adaptor for Phosphoinositide 3-kinase |
| Function | NYAP1 participates in critical neuronal signaling pathways: |
| Primary Expression | the brain and plays important roles in neuronal migration, synaptic plasticity, and neuronal survival |
| Molecular Weight | 42 kDa |
| Amino Acids | 380 aa |
| Pathways | PI3K, PI3K Signaling |
| GeneCards | NYAP1 |
| Human Protein Atlas | NYAP1 |
| PI3K Signaling | NYAP1 links activated receptors to PI3K/Akt signaling, a critical pathway for neuronal survival.<sup>[3]</sup> |
| Neuronal Migration | Involved in cortical neuronal migration during development. |
| Synaptic Plasticity | Dysregulation of NYAP1 may contribute to synaptic dysfunction in AD. |
| Neuronal Survival | PI3K/Akt signaling is neuroprotective. NYAP1 variants may impair this survival pathway. |
| [Tau](/proteins/tau) Phosphorylation | Akt regulates tau phosphorylation; NYAP1 variants may affect this pathway. |
| High Expression | Cerebral cortex, hippocampus, cerebellum |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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