gene

LATS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LATS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

88Connections

0Hypotheses

0Analyses

50Outgoing

23Incoming

0Experiments

0Debates

Summary

Page for LATS1 — Large Tumor Suppressor Kinase 1, Hippo Pathway

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🧬 Gene Info

Gene Symbol	LATS1
Full Name	Large Tumor Suppressor Kinase 1, Hippo Pathway
Chromosome	6q25.1
Protein Type	Serine/Threonine Kinase
Primary Expression	neural progenitors of the ventricular and subventricular zones, where it controls the balance between proliferation and differentiation
Amino Acids	130 aa
Exons	9
Pathways	Hippo Pathway, Yap/Taz
Ensembl ID	ENSG00000131023
GeneCards	LATS1
Human Protein Atlas	LATS1
SNAI1 (Snail)	LATS1 phosphorylation promotes Snail degradation, modulating epithelial-mesenchymal transition and neural crest cell migration
DYRK1A	LATS1 interacts with and modulates the activity of DYRK1A, a kinase implicated in Down syndrome and tau phosphorylation
p53	LATS1 stabilizes p53 by phosphorylating MDM2, linking Hippo signaling to DNA damage responses
Rab8A	LATS1 phosphorylates Rab8A to regulate ciliogenesis, connecting Hippo to primary cilium formation
Associated Diseases	Breast Cancer
Interactions	AND, APOPTOSIS, AUTOPHAGY, CANCER, EGF, ESR1
KG Connections	88 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LATS1 — Large Tumor Suppressor Kinase 1, Hippo Pathway

gene · 1653 words

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Pathway Diagram

graph TD
    LATS1["LATS1"]
    Cardiovascular["Cardiovascular"]
    LATS1 -->|"regulates"| Cardiovascular
    Cancer{"Cancer"}
    LATS1 -->|"regulates"| Cancer
    Ms{"Ms"}
    LATS1 -->|"regulates"| Ms
    Als{"Als"}
    LATS1 -->|"activates"| Als
    LATS1 -->|"interacts with"| Ms
    Tumor{"Tumor"}
    LATS1 -->|"interacts with"| Tumor
    LATS1 -->|"activates"| Cancer
    LATS1 -->|"activates"| Tumor
    Inflammation{"Inflammation"}
    LATS1 -->|"activates"| Inflammation
    DDB1["DDB1"]
    LATS1 -->|"regulates"| DDB1
    YAP["YAP"]
    LATS1 -->|"regulates"| YAP
    TAZ["TAZ"]
    LATS1 -->|"regulates"| TAZ
    MST1["MST1"]
    MST1 -->|"activates"| LATS1
    TAZ -->|"regulates"| LATS1
    DDB1 -->|"regulates"| LATS1
    HIPPO["HIPPO"]
    HIPPO -->|"interacts with"| LATS1
    UVRAG["UVRAG"]
    UVRAG -->|"activates"| LATS1
    PIK3C3["PIK3C3"]
    PIK3C3 -->|"activates"| LATS1
    PYROPTOSIS["PYROPTOSIS"]
    PYROPTOSIS -->|"activates"| LATS1
    YAP -->|"regulates"| LATS1
    CANCER["CANCER"]
    CANCER -->|"regulates"| LATS1
    HIPPO -->|"regulates"| LATS1
    style LATS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (65)

Target	Relation	Type	Str
Breast Cell Fate	regulates	process	0.95
bipotent progenitor cells	suppresses	cell_type	0.88
ESR1 ubiquitination	regulates	process	0.88
luminal phenotype	suppresses	phenotype	0.85
breast cancer	therapeutic_target	disease	0.85
ESR1	interacts_with	protein	0.85
Breast cancer	protects_against	disease	0.82
ERα	controls_cell_fate_via_crosstalk	protein	0.80
Tumor Suppression	involved_in	process	0.80
Breast Cancer	associated_with	disease	0.80
Cancer	regulates	disease	0.75
Luminal Epithelial Cell Differentiation	regulates	process	0.75
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Tumor	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Inflammation	activates	disease	0.65
Als	activates	disease	0.65
Ms	regulates	disease	0.65
Als	inhibits	disease	0.65
Inflammasome	activates	pathway	0.60
Pyroptosis	activates	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
TAZ	regulates	gene	0.60
TAZ	activates	gene	0.60
LATS2	activates	gene	0.60
XPC	activates	gene	0.60
NEK7	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
Yap/Taz	regulates	pathway	0.60
EGF	activates	gene	0.60
Rb	regulates	protein	0.60
Stat3	activates	protein	0.60
YAP	regulates	gene	0.60
Hippo Pathway	regulates	pathway	0.60
APOPTOSIS	activates	gene	0.60
YAP	activates	gene	0.60
Apoptosis	activates	pathway	0.60
CANCER	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
INFLAMMATION	activates	gene	0.60
Stem Cell	activates	cell_type	0.60
T Cell	activates	cell_type	0.60
AND	activates	gene	0.60
Angiogenesis	activates	pathway	0.60
Ubiquitin	regulates	protein	0.60
DDB1	regulates	gene	0.60
HIPPO	regulates	gene	0.60
CANCER	regulates	gene	0.60

Incoming (23)

Source	Relation	Type	Str
MST1	activates	gene	0.80
YAP	regulates	gene	0.70
TAZ	regulates	gene	0.70
UVRAG	activates	gene	0.60
PIK3C3	activates	gene	0.60
HIPPO	interacts_with	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
AND	activates	gene	0.60
MOB1	activates	gene	0.60
ROS	activates	gene	0.60
CANCER	activates	gene	0.60
YAP	activates	gene	0.60
RNA	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
HDAC6	activates	gene	0.60
TAZ	activates	gene	0.60
CANCER	regulates	gene	0.60
HIPPO	regulates	gene	0.60
DDB1	regulates	gene	0.60
HIPPO	inhibits	gene	0.60
GAIN	activates	gene	0.60
STAT3	activates	gene	0.60
PYROPTOSIS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LATS1 in their description or question text

No additional research found