protein

AGO2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AGO2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

114Connections

0Hypotheses

0Analyses

50Outgoing

26Incoming

0Experiments

0Debates

No summary available yet.

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🔬 Protein Info

Gene Symbol	AGO2
Full Name	Argonaute-2 (EIF2C2)
Chromosome	8q24.3
Function	Primary mediator of miRNA-guided mRNA cleavage
Molecular Weight	97 kDa
Amino Acids	859 aa
Pathways	Blood-Brain Barrier, Complement, Microrna
UniProt ID	Q9UKV8
NCBI Gene ID	27185
Ensembl ID	ENSG00000139318
OMIM	606228
GeneCards	AGO2
Human Protein Atlas	AGO2
Associated Diseases	Aging, Senescence
Interactions	ALYREF, AMPK, AND, APOPTOSIS, BCL-2, CANCER
KG Connections	114 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: AGO2 — AlphaFold Q9UKV8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

AGO2 (Argonaute-2)

gene · 660 words

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AGO2 Protein

protein · 826 words

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Pathway Diagram

graph TD
    AGO2["AGO2"] -->|"regulates"| STAT3["STAT3"]
    style STAT3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    AGO2["AGO2"] -.->|"inhibits"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AGO2["AGO2"] -.->|"inhibits"| Lymphoma["Lymphoma"]
    style Lymphoma fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AGO2["AGO2"] -.->|"inhibits"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AGO2["AGO2"] -.->|"inhibits"| Tumor["Tumor"]
    style Tumor fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AGO2["AGO2"] -->|"activates"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AGO2["AGO2"] -->|"activates"| Depression["Depression"]
    style Depression fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    MIRNAS["MIRNAS"] -->|"associated"| AGO2["AGO2"]
    style MIRNAS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TRF33["TRF33"] -->|"interacts"| AGO2["AGO2"]
    style TRF33 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    STAT3_1["STAT3"] -->|"regulates"| AGO2["AGO2"]
    style STAT3_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    BCL_2["BCL-2"] -.->|"inhibits"| AGO2["AGO2"]
    style BCL_2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TP53["TP53"] -->|"regulates"| AGO2["AGO2"]
    style TP53 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style AGO2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (88)

Target	Relation	Type	Str
STAT3	regulates	protein	0.70
PTEN	activates	gene	0.70
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Lymphoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Aging	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	activates	disease	0.65
Depression	activates	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
CANCER	regulates	disease	0.65
Aging	therapeutic_target	disease	0.65
Cancer	interacts_with	disease	0.65
Diabetes	activates	disease	0.65
Cardiomyopathy	activates	disease	0.65
Gastric Cancer	inhibits	disease	0.65
Senescence	therapeutic_target	disease	0.65
CANCER	interacts_with	gene	0.60
MICRORNAS	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
Cardiomyocyte	inhibits	cell_type	0.60
App	therapeutic_target	protein	0.60
LIN28B	interacts_with	gene	0.60
EXOSOMES	therapeutic_target	gene	0.60
AND	inhibits	gene	0.60
AGING	therapeutic_target	gene	0.60
RNA	interacts_with	gene	0.60
AND	regulates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
MIRNAS	inhibits	gene	0.60
autophagy pathway	participates_in	pathway	0.60
ALYREF	activates	gene	0.60
CANCER	stabilizes	disease	0.60
AMPK	activates	gene	0.60
Cell Cycle	inhibits	pathway	0.60
CDKN1A	inhibits	gene	0.60
Apoptosis	inhibits	pathway	0.60
CANCER	inhibits	gene	0.60
CCNG2	inhibits	gene	0.60
Metalloproteinase	inhibits	protein	0.60
Ras	inhibits	protein	0.60
CAV1	interacts_with	gene	0.60
Blood-Brain Barrier	regulates	pathway	0.60
Microrna	regulates	pathway	0.60

Incoming (26)

Source	Relation	Type	Str
MIRNAS	associated_with	gene	0.70
TRF33	interacts_with	gene	0.64
CAV1	interacts_with	gene	0.60
STAT3	inhibits	gene	0.60
MIRNAS	activates	gene	0.60
MICRORNAS	activates	gene	0.60
RNA	interacts_with	gene	0.60
MIR-302B	inhibits	gene	0.60
CDKN1A	inhibits	gene	0.60
GALNT3	inhibits	gene	0.60
STAT3	regulates	gene	0.60
MICRORNAS	regulates	gene	0.60
MIRNAS	inhibits	gene	0.60
RNA	associated_with	gene	0.60
HDAC6	activates	gene	0.60
EXOSOMES	therapeutic_target	gene	0.60
CCNG2	inhibits	gene	0.60
TP53	regulates	gene	0.60
BCL-2	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
GENES	inhibits	gene	0.60
AGING	associated_with	gene	0.60
EXOSOMES	associated_with	gene	0.60
CANCER	inhibits	gene	0.60
RNA	inhibits	gene	0.60
CANCER	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AGO2 in their description or question text

No additional research found