gene

DAG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DAG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

50Connections

1Hypotheses

0Analyses

42Outgoing

8Incoming

0Experiments

0Debates

Summary

DAG1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, implicated in, therapeutic target. Associated with AD, ALS, Als. Connected to 22 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	DAG1
Full Name	Dystroglycan 1
Chromosome	3p21.31
Function	Dystroglycan is a core component of the dystrophin-glycoprotein complex (DGC)
Molecular Weight	156 kDa
Exons	2
Pathways	Toll-Like Receptor
UniProt ID	Q07421
NCBI Gene ID	1745
Ensembl ID	ENSG00000173402
OMIM	128239
GeneCards	DAG1
Human Protein Atlas	DAG1
Associated Diseases	AD, Als, fibrosis, LOAD, Muscular Dystrophy
Interactions	BCL-2, DYSTROGLYCAN, RNA, TOLL
KG Connections	50 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DAG1 — AlphaFold Q07421 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DAG1 Gene

gene · 799 words

→

Pathway Diagram

graph TD
    DAG1["DAG1"]
    Als{"Als"}
    DAG1 -->|"therapeutic target"| Als
    Fibrosis{"Fibrosis"}
    DAG1 -->|"regulates"| Fibrosis
    DAG1 -->|"inhibits"| Als
    ALS{"ALS"}
    DAG1 -->|"regulates"| ALS
    BAD["BAD"]
    DAG1 -->|"regulates"| BAD
    HSPG2["HSPG2"]
    DAG1 -->|"regulates"| HSPG2
    BCL_2["BCL-2"]
    DAG1 -->|"regulates"| BCL_2
    IGF1R["IGF1R"]
    DAG1 -->|"regulates"| IGF1R
    Toll_Like_Receptor(["Toll-Like Receptor"])
    DAG1 -->|"regulates"| Toll_Like_Receptor
    Fibroblast["Fibroblast"]
    DAG1 -->|"expressed in"| Fibroblast
    AD{"AD"}
    DAG1 -->|"implicated in"| AD
    DAG1 -->|"implicated in"| Als
    HSPG2 -->|"regulates"| DAG1
    IGF1R -->|"regulates"| DAG1
    BCL_2 -->|"regulates"| DAG1
    ROS["ROS"]
    ROS -->|"regulates"| DAG1
    BAD -->|"regulates"| DAG1
    AND["AND"]
    AND -->|"regulates"| DAG1
    style DAG1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (42)

Target	Relation	Type	Str
Yap	binds	protein	0.80
POMGnT1	interacts_with	enzyme	0.80
Muscular Dystrophy	associated_with	disease	0.80
Cardiomyocyte Proliferation	inhibits	biological_process	0.80
Glycosylation	participates_in	biological_process	0.70
ALS	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Fibrosis	regulates	disease	0.65
Als	inhibits	disease	0.65
IGF1R	regulates	gene	0.60
HSPG2	activates	entity	0.60
IGF1R	activates	entity	0.60
TOLL	activates	gene	0.60
BCL-2	regulates	gene	0.60
Fibroblast	regulates	cell_type	0.60
BAD	regulates	gene	0.60
HSPG2	regulates	gene	0.60
Toll-Like Receptor	regulates	pathway	0.60
ALS	associated_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
Insulin	regulates	protein	0.60
Interleukin	regulates	protein	0.60
Metalloproteinase	therapeutic_target	protein	0.60
Igf	regulates	protein	0.60
App	therapeutic_target	protein	0.60
RNA	activates	gene	0.60
ROS	regulates	gene	0.60
AND	regulates	gene	0.60
RNA	regulates	gene	0.60
Fibroblast	expressed_in	cell_type	0.55
INSULIN	activates	concept	0.50
FIBROBLASTS	activates	concept	0.50
DYSTROGLYCAN	activates	protein	0.50
BCL-2	activates	protein	0.50
LOAD	implicated_in	disease	0.50
fibrosis	implicated_in	disease	0.50
FIBROSIS	activates	disease	0.50
AD	implicated_in	disease	0.50
Als	implicated_in	disease	0.50
RA	implicated_in	disease	0.50
IGF1R	co_expressed_with	gene	0.50
SS	implicated_in	disease	0.50

Incoming (8)

Source	Relation	Type	Str
BAD	activates	entity	0.60
RNA	regulates	gene	0.60
BAD	regulates	gene	0.60
HSPG2	regulates	gene	0.60
IGF1R	regulates	gene	0.60
BCL-2	regulates	gene	0.60
ROS	regulates	gene	0.60
BAD	co_expressed_with	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Restore AQP4 Perivascular Polarization by Stabilizing DAPC/S	0.670	neurodegeneration	How can AQP4 be effectively targeted the

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DAG1 in their description or question text

No additional research found