gene

TLR6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TLR6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

10Outgoing

1Incoming

0Experiments

0Debates

Summary

TLR6 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Alzheimer. Connected to 12 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	TLR6
Full Name	Toll-Like Receptor 6
Chromosome	4p14
Protein Type	Receptor
Function	TLR6 typically forms heterodimers with TLR2 to recognize a broad range of ligands:
Primary Expression	various cell types with highest expression in immune cells:
Molecular Weight	91 kDa
Amino Acids	200 aa
Pathways	Lysosomal Degradation
UniProt ID	Q9NYK5
NCBI Gene ID	10333
Ensembl ID	ENSG00000174128
OMIM	607209
GeneCards	TLR6
Human Protein Atlas	TLR6
Associated Diseases	neurodegeneration
Interactions	ALZHEIMER'S DISEASE, AQP4, ASTROCYTES, GFAP, GJA1, IL1B
KG Connections	11 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TLR6 — AlphaFold Q9NYK5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TLR6 Gene

gene · 923 words

→

TLR6 Protein

protein · 591 words

→

Pathway Diagram

graph TD
    TLR6["TLR6"]
    Alzheimer{"Alzheimer"}
    TLR6 -->|"activates"| Alzheimer
    MICROGLIA["MICROGLIA"]
    TLR6 -->|"activates"| MICROGLIA
    GFAP["GFAP"]
    TLR6 -->|"activates"| GFAP
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    TLR6 -->|"activates"| ALZHEIMER_S_DISEASE
    IL1B["IL1B"]
    TLR6 -->|"activates"| IL1B
    ASTROCYTES["ASTROCYTES"]
    TLR6 -->|"activates"| ASTROCYTES
    TNF["TNF"]
    TLR6 -->|"activates"| TNF
    VIM["VIM"]
    TLR6 -->|"activates"| VIM
    GJA1["GJA1"]
    TLR6 -->|"activates"| GJA1
    Lysosomal_Degradation(["Lysosomal Degradation"])
    TLR6 -->|"activates"| Lysosomal_Degradation
    neurodegeneration["neurodegeneration"]
    TLR6 -->|"implicated in"| neurodegeneration
    AQP4["AQP4"]
    AQP4 -->|"activates"| TLR6
    style TLR6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Alzheimer	activates	disease	0.65
IL1B	activates	gene	0.60
TNF	activates	gene	0.60
VIM	activates	gene	0.60
GJA1	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
GFAP	activates	gene	0.60
Lysosomal Degradation	activates	pathway	0.60

Incoming (1)

Source	Relation	Type	Str
AQP4	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TLR6 in their description or question text

No additional research found