concept

DENND3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DENND3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

0Hypotheses

0Analyses

36Outgoing

27Incoming

0Experiments

0Debates

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💡 Concept Info

Name	DENND3
Key Genes/Proteins	AND, CDC42, CYCS, DIABETES MELLITUS, GENES, GFAP
Related Diseases	Diabetes, Inflammation

Pathway Diagram

graph TD
    DENND3["DENND3"]
    DENND3 -->|"upregulates"| Type_2_Diabetes_Mellitus_with_["Type 2 Diabetes Mellitus with Parkinson's Disease"]
    DENND3 -->|"involved_in"| Immune_Response["Immune Response"]
    DENND3 -->|"target for"| Parkinson["Parkinson"]
    DENND3 -->|"target for"| Diabetes["Diabetes"]
    DENND3 -->|"regulates"| AND["AND"]
    DENND3 -->|"regulates"| GENES["GENES"]
    DENND3 -->|"regulates"| RAC1["RAC1"]
    DENND3 -->|"target for"| NCF1["NCF1"]
    MGA["MGA"] -->|"regulates"| DENND3
    TPM2["TPM2"] -->|"regulates"| DENND3
    RAC1 -->|"regulates"| DENND3
    GENES -->|"regulates"| DENND3
    HUB_GENES["HUB GENES"] -->|"regulates"| DENND3
    VIM["VIM"] -->|"target for"| DENND3
    GFAP["GFAP"] -->|"target for"| DENND3
    MMP9["MMP9"] -->|"target for"| DENND3

Outgoing (36)

Target	Relation	Type	Str
Type 2 Diabetes Mellitus with Parkinson's Disease	upregulates	disease	0.80
Immune Response	involved_in	process	0.75
Inflammation	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
MMP9	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
MGA	regulates	gene	0.60
TPM2	regulates	gene	0.60
CDC42	therapeutic_target	gene	0.60
CYCS	therapeutic_target	gene	0.60
VIM	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
GFAP	therapeutic_target	gene	0.60
NCF1	therapeutic_target	gene	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
SOD2	therapeutic_target	gene	0.60
Oxidative Stress	associated_with	pathway	0.60
AND	regulates	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
GENES	regulates	gene	0.60
CDC42	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
SOD2	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
CYCS	associated_with	gene	0.60
RAC1	regulates	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
MET	associated_with	gene	0.60
HUB GENES	regulates	gene	0.60
VIM	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
NCF1	associated_with	gene	0.60

Incoming (27)

Source	Relation	Type	Str
TPM2	associated_with	gene	0.70
GFAP	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
VIM	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
CYCS	associated_with	gene	0.60
MGA	regulates	gene	0.60
TPM2	regulates	gene	0.60
RAC1	regulates	gene	0.60
PARKINSON	associated_with	gene	0.60
CDC42	associated_with	gene	0.60
SOD2	associated_with	gene	0.60
GENES	regulates	gene	0.60
MMP9	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
MET	associated_with	gene	0.60
NCF1	associated_with	gene	0.60
VIM	therapeutic_target	gene	0.60
HUB GENES	regulates	gene	0.60
GFAP	therapeutic_target	gene	0.60
MMP9	therapeutic_target	gene	0.60
CYCS	therapeutic_target	gene	0.60
SOD2	therapeutic_target	gene	0.60
NCF1	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DENND3 in their description or question text

No additional research found