gene

TAK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

257Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

TAK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Als, Alzheimer, Cancer. Connected to 152 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	TAK1
Aliases	Transforming Growth Factor-beta-Activated Kinase 1
Chromosome	6q15
Protein Family	MAP3K kinases
Protein Type	Kinase
Function	TAK1 (Transforming Growth Factor-beta-Activated Kinase 1) is a serine/threonine kinase that activates NF-κB and MAPK pathways in response to cytokines (TNF-α, IL-1), TLR ligands, and stress.
Molecular Weight	67 kDa
Pathways	NF-κB, MAPK pathway, NF-κB Signaling, MAPK Signaling, MAPK
UniProt ID	[O43318](https://www.uniprot.org/uniprot/O43318)
GeneCards	TAK1
Human Protein Atlas	TAK1
Associated Diseases	Encephalitis, Multiple Sclerosis, neuroinflammation
Interactions	ALOX12, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections	254 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TAK1["TAK1"] -->|"activates"| Cancer["Cancer"]
    TAK1["TAK1"] -->|"activates"| Als["Als"]
    TAK1["TAK1"] -->|"activates"| Ms["Ms"]
    TAK1["TAK1"] -.->|"inhibits"| Als_1["Als"]
    TAK1["TAK1"] -->|"therapeutic target"| Cancer_2["Cancer"]
    TAK1["TAK1"] -.->|"inhibits"| Tumor["Tumor"]
    P38["P38"] -->|"activates"| TAK1["TAK1"]
    MAP1LC3["MAP1LC3"] -->|"activates"| TAK1["TAK1"]
    IL1B["IL1B"] -->|"activates"| TAK1["TAK1"]
    PRDX1["PRDX1"] -->|"activates"| TAK1["TAK1"]
    style TAK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (178)

Target	Relation	Type	Str
mitochondrial_transfer	mediates	mechanism	0.95
TNF-α signaling	regulates	pathway	0.88
Tumor	activates	disease	0.85
Cancer	activates	disease	0.85
POMC neurons	modulates	unknown	0.85
Als	activates	disease	0.85
UBIQUITIN	activates	gene	0.80
CANCER	activates	gene	0.80
mitochondrial_dysfunction	inhibits	mechanism	0.75
Cancer	therapeutic_target	disease	0.75
AUTOPHAGY	activates	gene	0.70
Apoptosis	activates	pathway	0.70
Autophagy	activates	pathway	0.70
Colorectal Cancer	activates	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Infection	activates	disease	0.65
Aging	activates	disease	0.65
Huntington	activates	disease	0.65
Fibrosis	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Diabetes	activates	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Tumor	inhibits	disease	0.65
Type 2 Diabetes	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	regulates	disease	0.65
Encephalitis	associated_with	disease	0.65
PAK1	associated_with	gene	0.60
NEK7	associated_with	gene	0.60
JNK	associated_with	gene	0.60
LIMK1	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
ASC	associated_with	gene	0.60
GSDMD	associated_with	gene	0.60
ubiquitination	activates	process	0.60
Apoptosis	regulates	pathway	0.60
Inflammasome	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
Pyroptosis	regulates	pathway	0.60
Necroptosis	regulates	pathway	0.60
Nf-Κb	interacts_with	pathway	0.60
OTUD5	inhibits	gene	0.60
AND	activates	gene	0.60
Podocyte	inhibits	cell_type	0.60

Incoming (79)

Source	Relation	Type	Str
MAP3K7	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
APEX2	activates	gene	0.60
ROS	inhibits	gene	0.60
RNA	activates	gene	0.60
APP	activates	gene	0.60
KRAS	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
IL1B	activates	gene	0.60
PRDX1	activates	gene	0.60
TRAF6	activates	gene	0.60
CHUK	activates	gene	0.60
PRDX6	activates	gene	0.60
MAPK14	activates	gene	0.60
BECN1	activates	gene	0.60
TNF	activates	gene	0.60
ECSIT	activates	gene	0.60
TLR4	activates	gene	0.60
RELA	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
LC3	activates	gene	0.60
IKBKB	activates	gene	0.60
IL6	activates	gene	0.60
MAPK8	inhibits	gene	0.60
JUN	therapeutic_target	gene	0.60
MAP3K7	inhibits	gene	0.60
ERN1	inhibits	gene	0.60
RIPK1	activates	gene	0.60
ZBP1	activates	gene	0.60
RIPK3	activates	gene	0.60
RIPK1	regulates	gene	0.60
ZBP1	regulates	gene	0.60
RIPK3	regulates	gene	0.60
NLRP3	regulates	gene	0.60
FADD	regulates	gene	0.60
STUB1	interacts_with	gene	0.60
ERK1	therapeutic_target	gene	0.60
JNK1	therapeutic_target	gene	0.60
TFEB	activates	gene	0.60
PP2A	activates	gene	0.60
KEAP1	activates	gene	0.60
SQSTM1	activates	gene	0.60
ROS	activates	gene	0.60
APP/PS1	activates	gene	0.60
LYSOSOME	activates	gene	0.60
P38	activates	gene	0.60
MAPK	activates	gene	0.60
NF-KB	activates	gene	0.60
NFKB	activates	gene	0.60
INFLAMMATION	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TAK1 Pathway Modulators for Hypothalamic Metabolic Disorders	0.000	-	Mitochondrial transfer between astrocyte

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TAK1 in their description or question text

No additional research found

TAK1

Understanding Entity Pages

Summary

Wiki Pages (8)

TAK1 Protein

TAB1 — TAK1-Binding Protein 1

TAK1 Protein

RIPK1-TAK1 Interaction Inhibitor

TAB2 Protein (TAK1-Binding Protein 2)

TAB3 Protein — TAK1-Binding Protein 3

TAK1 Gene

TAB1 Protein (TAK1-Binding Protein 1)