| Gene Symbol | TAB3 |
| Full Name | TAK1-Binding Protein 3 |
| Protein Family | TAK1-binding proteins |
| Protein Type | Adaptor Protein |
| Function | TAB3 is a homolog of TAB2 that also links TAK1 to TRAF6 in NF-κB signaling. |
| Molecular Weight | 93 kDa |
| Pathways | NF-κB, MAPK signaling, mapk, TGF-β, NF-κB pathway |
| UniProt ID | [Q9N2I8](https://www.uniprot.org/uniprot/Q9N2I8) |
| GeneCards | TAB3 |
| Human Protein Atlas | TAB3 |
| N-terminal ubiquitin-binding domain | Binds Lys63-linked polyubiquitin chains |
| C-terminal TAB2/3 homology domain | Mediates interaction with TAK1 |
| Coiled-coil regions | Facilitate protein-protein interactions |
| TAK1-binding region | Direct interaction site for TAK1 kinase |
| NF-κB pathway | Canonical and non-canonical NF-κB activation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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