| Gene Symbol | TAK1 |
| Aliases | Transforming Growth Factor-beta-Activated Kinase 1 |
| Chromosome | 6q15 |
| Protein Family | MAP3K kinases |
| Protein Type | Kinase |
| Function | TAK1 (Transforming Growth Factor-beta-Activated Kinase 1) is a serine/threonine kinase that activates NF-κB and MAPK pathways in response to cytokines (TNF-α, IL-1), TLR ligands, and stress. |
| Molecular Weight | 67 kDa |
| Pathways | NF-κB, MAPK pathway, NF-κB Signaling, MAPK Signaling, MAPK |
| UniProt ID | [O43318](https://www.uniprot.org/uniprot/O43318) |
| GeneCards | TAK1 |
| Human Protein Atlas | TAK1 |
| Associated Diseases | Encephalitis, Multiple Sclerosis, neuroinflammation |
| Interactions | ALOX12, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMPK, AMYLOID |
| KG Connections | 254 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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