entity

mitochondrial_transfer

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about mitochondrial_transfer: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

5Hypotheses

4Analyses

38Outgoing

19Incoming

20Experiments

4Debates

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Outgoing (38)

Target	Relation	Type	Str
neuroprotection	mediates	phenotype	0.95
peripheral neuropathy	protects_against	unknown	0.95
brain injury	involved_in	unknown	0.95
neurodegeneration	involved_in	disease	0.95
blood-brain barrier integrity	associated_with	unknown	0.95
tumour_microenvironment	involved_in	unknown	0.90
mitochondrial_dysfunction	mediates	mechanism	0.90
neuroprotection	contributes_to	phenotype	0.90
glucose homeostasis	contributes_to	unknown	0.90
cholesterol homeostasis	contributes_to	unknown	0.90
neuropathic pain	protects_against	unknown	0.90
Parkinson's disease	involved_in	unknown	0.90
glioblastoma	associated_with	unknown	0.85
oxidative_stress	contributes_to	phenotype	0.85
therapy_resistance	contributes_to	unknown	0.85
cell survival	contributes_to	unknown	0.85
mitochondrial_dysfunction	contributes_to	mechanism	0.85
mitochondrial_dysfunction	associated_with	mechanism	0.85
ischemic stroke	involved_in	unknown	0.85
neurodegeneration	contributes_to	disease	0.85
neurodegeneration	associated_with	disease	0.85
nerve degeneration	associated_with	unknown	0.85
oxidative_stress	modulates	phenotype	0.82
ischemia/reperfusion injury	mediates	unknown	0.80
oxidative stress	modulates	mechanism	0.80
small fibre neuropathy	associated_with	unknown	0.80
mitochondrial_dysfunction	modulates	mechanism	0.80
neuronal survival	modulates	unknown	0.80
HK2	associated_with	protein	0.80
neurodegeneration	inhibits	disease	0.80
aging-associated BBB breakdown	involved_in	unknown	0.80
alzheimers	involved_in	disease	0.80
cognitive functions	modulates	unknown	0.79
oxidative_stress	associated_with	phenotype	0.75
microglial_activation	modulates	mechanism	0.75
neuroinflammation	involved_in	mechanism	0.75
tumour_invasion	contributes_to	unknown	0.75
glymphatic_clearance	associated_with	mechanism	0.70

Incoming (19)

Source	Relation	Type	Str
astrocytes	involved_in	cell_type	0.95
Mfn2 deletion	inhibits	unknown	0.95
MYO10	mediates	unknown	0.95
melatonin	promotes	drug	0.95
Tak1	mediates	unknown	0.95
Dmp1-expressing astrocytes	mediates	unknown	0.95
CD38	involved_in	protein	0.90
aging	associated_with	unknown	0.85
astrocytes	activates	cell_type	0.80
oxidative_stress	inhibits	phenotype	0.80
HSP70	involved_in	protein	0.75
APOE4	modulates	protein	0.72
HSP70	mediates	protein	0.71
mitochondrial DNA release	associated_with	mechanism	0.70
microglial_activation	associated_with	mechanism	0.70
TFAM	involved_in	protein	0.70
TFAM	associated_with	protein	0.70
TFEB	modulates	protein	0.68
glymphatic_clearance	associated_with	mechanism	0.65

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Mitochondrial Transfer Pathway Enhancement	0.695	neurodegeneration	Astrocyte reactivity subtypes in neurode
CX43 hemichannel engineering enables size-selective mitochon	0.686	neurodegeneration	Mitochondrial transfer between astrocyte
GAP43-mediated tunneling nanotube stabilization enhances neu	0.666	neurodegeneration	Mitochondrial transfer between astrocyte
Optogenetic Control of Mitochondrial Transfer Networks	0.476	neurodegeneration	Mitochondrial transfer between neurons a
Astrocyte CD38-erk Mapk signaling controls mitochondrial tra	0.000	ALS and Alzheimer's disease	Mitochondrial transfer between neurons a

Mentioning Analyses (4)

Scientific analyses that reference this entity

What is the relative contribution of connexin-43 gap junctions vs tunneling nano

cell biology | 2026-04-12 | 2 hypotheses Top: 0.724

Do transferred mitochondria from diseased astrocytes carry pathological damage t

neurodegeneration | 2026-04-11 | 0 hypotheses

Mitochondrial transfer between neurons and glia

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.559

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (20)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Cx43 knockdown effects on mitochondrial transfer	exploratory	osteoarthritis	0.900	0.00	human bone marrow-derived MSCs	proposed	N/A
Confocal imaging of MSC-chondrocyte interactions during mitochondrial	exploratory	osteoarthritis	0.850	0.00	human bone marrow-derived MSCs	proposed	N/A
Auditory nerve responses to combined optogenetic and electrical stimul	validation	sensorineural hearing loss/dea	0.850	0.00	transgenic mice expressing ChR	proposed	N/A
s:** - Test MCU overexpression specifically in layer II neurons in hea	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$200,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Mechanism: Selective Vulnerability of Dopaminergic Neurons in Parkinso	validation	Parkinson's Disease	0.400	0.50	human	proposed	$3,000,000
Selective Vulnerability of Dopaminergic Neurons — Mechanism and Protec	validation	Neurodegeneration	0.400	0.50	cell_line	proposed	$160,000
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Exercise-BDNF-Mitophagy Biomarker Study in PD	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Ferroptosis Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
GLP-1 Agonist Neuroprotection Mechanism in PD	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Cytochrome Therapeutics	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
AAV-LRRK2 IND-Enabling Study Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Gap Junction Dysfunction Validation in Parkinson's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
AAV-LRRK2 Gene Therapy IND-Enabling Study Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in Parkinson'	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Axonal Transport Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Selective Neuronal Vulnerability to Aging — Mapping Why Specific Neuro	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
Synaptic Mitochondrial Resilience Enhancement for Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Enhancer AAVs for targeting spinal motor neurons and descending motor pathways i [PMID:40403722]	Emily Kussick, Nelson Johansen, Naz Task	Cell Reports	2025	19
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886]	Yao RQ, Ren C, Xia ZF, Yao YM	Autophagy	2021	2
Astrocytic Connexin43 in Alzheimer's disease: mechanisms, interaction with P2 re [PMID:41062060]	Xiong W, Su Y, Verkhratsky A, Yi C	Neuropharmacology	2026	1
Miro1: A potential target for treating neurological disorders. [PMID:40403957]	Zeng L, Yang J, Zhang C, Zhu J, Zhong S,	Neuroscience	2025	1
Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates co [PMID:40595567]	Su Y, Li H, Zhang W, Tao S, Wang Q, Zhan	Nat Commun	2025	1
Calcium-Associated Proteins in Neuroregeneration. [PMID:38397420]	Lisek M, Tomczak J, Boczek T, Zylinska L	Biomolecules	2024	1
Should it stay or should it go: gap junction protein GJA1/Cx43 conveys damaged l [PMID:39394955]	Domingues N, Ribeiro-Rodrigues T, Girão	Autophagy	2024	1
Connexin 43 regulates intercellular mitochondrial transfer from human mesenchyma [PMID:39390589]	Irwin RM, Thomas MA, Fahey MJ, Mayán MD,	Stem Cell Res Ther	2024	1
Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorpt [PMID:38877020]	Ding P, Gao C, Zhou J, Mei J, Li G, Liu	Nat Commun	2024	1
Selective inhibition of cannabinoid CB(1) receptor-evoked signalling by the inte [PMID:37689260]	Maroto IB, Moreno E, Costas-Insua C, Mer	Neuropharmacology	2023	1
lncRNA LOC100911717-targeting GAP43-mediated sympathetic remodeling after myocar [PMID:36684596]	Li P, Wang K, Yin J, Qi L, Hu H, Yang P,	Front Cardiovasc Med	2022	1
Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217]	Chang CH, Lin CH, Lane HY	Int J Mol Sci	2021	1
Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration. [PMID:34199470]	Boal AM, Risner ML, Cooper ML, Wareham L	Cells	2021	1
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote qualit [PMID:34873283]	König T, Nolte H, Aaltonen MJ, Tatsuta T	Nat Cell Biol	2021	1
Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal ste [PMID:24431222]	Ahmad T, Mukherjee S, Pattnaik B, Kumar	EMBO J	2014	1
Nerve growth cone motility. [PMID:2139335]	Lankford K, Cypher C, Letourneau P	Curr Opin Cell Biol	1990	1
L-Carnitine and Acetyl-L-Carnitine in Drug Poisonings: A Systematic Review of Cl [PMID:41692009]	["Rezaee H", "Abbasgholizadeh F"]	Journal of applied toxicology	2026	0
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline [PMID:41618855]	["Ying H", "Fan H", "Wang Y", "Jiang R",	Advanced science (Weinheim, Ba	2026	0
Prenatal lipopolysaccharide exposure programs cardiac fibrosis via dysregulating [PMID:41789580]	Wen Y, Yuan Y, Zhang H, Liu Y	Molecular medicine reports	2026	0
Astrocytes Protect Brain Metastatic Breast Cancer Cells From Chemotherapy Throug [PMID:41486609]	Yakati V, Rao SS	Biotechnol Bioeng	2026	0

Debates (4)

Multi-agent debates referencing this entity

The debate highlighted that mitochondrial transfer could be therapeutic, but rai

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

The debate revealed conflicting evidence about whether connexin-43 mediates mito

closed · Rounds: 4 · Score: 0.74 · 2026-04-12

What are the mechanisms underlying mitochondrial transfer between neurons and gl

closed · Rounds: 5 · Score: 0.81 · 2026-04-01

What are the mechanisms underlying mitochondrial transfer between astrocytes and

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning mitochondrial_transfer in their description or question text

No additional research found