gene

KCNK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

495Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

9Experiments

2Debates

Summary

KCNK2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with ALS, Als, Anxiety. Connected to 272 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	KCNK2
Full Name	Potassium Two Pore Domain Channel Subfamily K Member 2
Aliases	TREK-1, TASK-1 Potassium Channel
Chromosome	1q41
Protein Type	Ion Channel
Target Class	Ion Channel
Function	Small molecule channel modulation
Mechanism of Action	KCNK2 encodes a two-pore domain potassium channel (TREK-1) that regulates neuronal excitability, membrane potential, and cellular responsiveness to mechanical and chemical stimuli in the central nervous system. In neurodegeneration, TREK-1 modulation can influence neuronal survival, mitochondrial function, and potentially mitigate oxidative stress and excitotoxicity through precise potassium conductance regulation.
Subcellular Localization	somatodendritic compartments
Druggability	Medium (0.58)
Clinical Stage	Approved
Molecular Weight	56 kDa
Pathways	Membrane Potential
UniProt ID	O95069
NCBI Gene ID	5136
Ensembl ID	ENSG00000024048
OMIM	607412
GeneCards	KCNK2
Human Protein Atlas	KCNK2
Associated Diseases	Als, ANTIDEPRESSANT_RESPONSE, Autoimmune, Cancer, depression
Known Drugs/Compounds	BL1249, DEX, ML335, ML-402, Spadin
Interactions	AND, ANG, APOPTOSIS, App, C1Q, CANCER
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Aquaporin-4 Polarization Enhancement via TREK-1 Ch
KG Connections	495 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNK2 — AlphaFold O95069 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KCNK2 Gene

gene · 959 words

→

KCNK2 Protein (TASK-1 Potassium Channel)

protein · 1113 words

→

Pathway Diagram

graph TD
    KCNK2["KCNK2"] -->|"associated"| neurodegeneration["neurodegeneration"]
    KCNK2["KCNK2"] -->|"interacts"| PIEZO1["PIEZO1"]
    KCNK2["KCNK2"] -->|"co discussed"| TET2["TET2"]
    KCNK2["KCNK2"] -->|"co discussed"| PIEZO1_1["PIEZO1"]
    KCNK2["KCNK2"] -->|"co discussed"| P2RX7["P2RX7"]
    KCNK2["KCNK2"] -->|"co discussed"| DGAT1["DGAT1"]
    PIEZO1_2["PIEZO1"] -->|"interacts"| KCNK2["KCNK2"]
    BMAL1["BMAL1"] -->|"co discussed"| KCNK2["KCNK2"]
    HK2["HK2"] -->|"co discussed"| KCNK2["KCNK2"]
    MIRO1["MIRO1"] -->|"co discussed"| KCNK2["KCNK2"]
    style KCNK2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (331)

Target	Relation	Type	Str
TREK1	encodes	protein	1.00
Cellular Excitability	regulates	process	0.95
Potassium Ion Transport	involved_in	process	0.95
adipocyte	expressed_in	cell_type	0.95
K2P channels	involved_in	protein	0.95
Conventional Outflow	regulates	process	0.95
Trabecular Meshwork	expressed_in	cell_type	0.95
Intraocular Pressure	regulates	phenotype	0.95
Influenza A-induced lung injury	protects_against	disease	0.95
Influenza A Virus-Induced Lung Injury	protects_against	disease	0.95
potassium leak	mediates	process	0.95
Adipocyte Differentiation	regulates	process	0.95
Conventional Aqueous Humor Outflow	regulates	process	0.95
AQUEOUS HUMOR OUTFLOW	regulates	entity	0.93
Lipid Accumulation	regulates	process	0.93
MECHANOSENSATION	involved_in	entity	0.92
INTRAOCULAR PRESSURE	regulates	entity	0.92
Calcium Influx	modulates	process	0.90
lymphocyte migration	modulates	process	0.90
brain endothelial cells	expressed_in	cell_type	0.90
Fat Mass Accumulation	regulates	phenotype	0.90
blood-brain barrier dysfunction	contributes_to	phenotype	0.90
Temperature Gating	involved_in	mechanism	0.90
lipid accumulation	suppresses	process	0.90
Leukocyte Trafficking	inhibits	process	0.90
Lymphocyte Migration	regulates	process	0.90
Blood-Brain Barrier Dysfunction	regulates	process	0.90
Periodontal Ligament Cell	expressed_in	cell_type	0.90
Membrane Potential	regulates	mechanism	0.90
Ca2+ Influx	modulates	mechanism	0.90
Adipocytes	expressed_in	cell_type	0.90
Leukocyte Trafficking	modulates	process	0.87
neurovascular unit	involved_in	brain_region	0.85
cellular excitability	modulates	phenotype	0.85
Multiple Sclerosis	associated_with	disease	0.85
Glucose Tolerance	regulates	phenotype	0.85
Glucocorticoid-Induced Ocular Hypertension	associated_with	disease	0.85
inflammatory phenotype	protects_against	phenotype	0.85
CXCL10	downregulates	gene	0.85
Alveolar Epithelial Cell	expressed_in	cell_type	0.85
Adipocyte Differentiation	involved_in	process	0.85
Mechanosensation	mediates	process	0.85
Ocular Hypertension	protects_against	disease	0.85
3T3-L1 Adipocytes	expressed_in	cell_type	0.85
Cell Membrane Potential Hyperpolarization	mediates	process	0.85
IL6	downregulates	gene	0.85
TNF	downregulates	gene	0.85
calcium influx	inhibits	process	0.85
Lymphocyte Migration	inhibits	process	0.85
Blood-Brain Barrier Function	regulates	process	0.85

Incoming (164)

Source	Relation	Type	Str
Heat	activates	phenotype	0.95
DEXAMETHASONE	downregulates	entity	0.95
h-9eae33ba	targets	hypothesis	0.90
TNF	upregulates	entity	0.90
Dexamethasone	downregulates	drug	0.90
ML-402	activates	compound	0.90
ML335	activates	compound	0.90
BL1249	activates	compound	0.90
Spadin	inhibits	drug	0.88
TNF-Α	upregulates	protein	0.85
Inflammation	downregulates	process	0.85
TNF	modulates	protein	0.80
h-db6aa4b1	targets	hypothesis	0.80
DEX	inhibits	drug	0.72
MIR132_3P	inhibits	gene	0.72
MIR214	inhibits	gene	0.72
NFKB1	interacts_with	gene	0.70
TNFA	regulates	protein	0.64
PLGF	activates	protein	0.64
CFTR	associated_with	gene	0.60
TRPV4	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
KCNMA1	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
TNF	expressed_in	gene	0.60
TRPA1	expressed_in	gene	0.60
TRPM8	expressed_in	gene	0.60
TRPC1	activates	gene	0.60
FSP1	activates	gene	0.60
KCNMA1	causes	gene	0.60
KCNQ1	causes	gene	0.60
PIEZO1	causes	gene	0.60
CFTR	causes	gene	0.60
SCN1A	causes	gene	0.60
TRPA1	causes	gene	0.60
KCNN4	causes	gene	0.60
PIEZO2	causes	gene	0.60
SCN5A	causes	gene	0.60
TRPV4	causes	gene	0.60
SCNN1A	causes	gene	0.60
TRPV1	causes	gene	0.60
TRPV4	activates	gene	0.60
DEPRESSION	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu	0.668	neurodegeneration	Perivascular spaces and glymphatic clear

Mentioning Analyses (2)

Scientific analyses that reference this entity

Perivascular spaces and glymphatic clearance failure in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.841

Astrocyte reactivity subtypes in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.741

Experiments (9)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
TREK-1 regulation of conventional outflow facility in mouse eyes	validation	ocular hypertension	0.900	0.00	mouse eyes	proposed	N/A
DEX effects on TREK-1 currents in human primary TM cells	exploratory	corticosteroid-induced ocular	0.900	0.00	primary human trabecular meshw	proposed	N/A
TREK-1 effects on IOP in DEX-induced mouse OHT model	validation	dexamethasone-induced ocular h	0.900	0.00	mouse eyes	proposed	N/A
DEX effects on K2P channel transcriptome in mouse TM cells	exploratory	corticosteroid-induced ocular	0.900	0.00	mouse trabecular meshwork cell	proposed	N/A
TREK-1 effects on spontaneous OHT in rats using telemetry	validation	spontaneous ocular hypertensio	0.800	0.00	rat eyes	proposed	N/A
TREK-1 localization in trabecular meshwork by immunohistochemistry	exploratory	ocular hypertension	0.800	0.00	trabecular meshwork tissue	proposed	N/A
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$240,000
s:** - Test tau spreading in AQP4 knockout vs wild-type mice with PSP/	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$260,000
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Novel function of TREK-1 in regulating adipocyte differentiation and lipid accum [PMID:40057491]	Kim A, Jung S, Kim Y, Jung J, Lee S, Lee	Cell Death Dis	2025	1
Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regulate Conventional Outf [PMID:41268978]	Redmon SN, Yarishkin O, Rudzitis CN, Lak	Invest Ophthalmol Vis Sci	2025	1
Activation of TREK-1 (K(2P)2.1) potassium channels protects against influenza A- [PMID:36410022]	Zyrianova T, Lopez B, Zou K, Gu C, Pham	Am J Physiol Lung Cell Mol Phy	2023	1
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci f [PMID:30061609]	Wyss AB, Sofer T, Lee MK, Terzikhan N, N	Nat Commun	2018	1
Temperature sensitivity of two-pore (K2P) potassium channels. [PMID:25366235]	Schneider ER, Anderson EO, Gracheva EO,	Curr Top Membr	2014	1
TREK-king the blood-brain-barrier. [PMID:24557892]	Bittner S, Ruck T, Fernández-Orth J, Meu	J Neuroimmune Pharmacol	2014	1
The Glymphatic-Venous Axis in Brain Clearance Failure: Aquaporin-4 Dysfunction, [PMID:41226584]	["Costea D", "Dobrin N", "Tataru C", "To	International journal of molec	2025	0
Genetic Insights into Brain Morphology: a Genome-Wide Association Study of Corti [PMID:40167904]	["Kim N", "Chowdhury N", "Buetow K", "Th	Neuroinformatics	2025	0
Calcium-dependent activation of TREK-1 and TREK-2 background potassium channels [PMID:41457157]	Baukál D, Pergel E, Debreczeni D, Horvát	Scientific reports	2025	0
The two-pore domain potassium channel KCNK5 deteriorates outcome in ischemic neu [PMID:25315980]	Göb E, Bittner S, Bobak N, Kraft P, Göbe	Pflugers Archiv : European jou	2015	0
Systemic mastocytosis in the elderly. [PMID:23436294]	["Butterfield J", "Weiler C"]	American journal of hematology	2013	0
Pandemic flu buddy system [PMID:19933817]	Thomas Ungar	CMAJ : Canadian Medical Associ	2009	0
Management of recalled pacemakers and defibrillators. [PMID:17081081]	Marco Cavagna; S Adam Strickberger	Expert review of cardiovascula	2006	0
Carbon catabolite repression regulates amino acid permeases in Saccharomyces cer [PMID:16407266]	["Peter G", "D\u00fcring L", "Ahmed A"]	The Journal of biological chem	2006	0
Politics and health [PMID:14747619]	D Barr; L Fenton; D Edwards	QJM : monthly journal of the A	2004	0

Debates (2)

Multi-agent debates referencing this entity

Astrocyte reactivity subtypes in neurodegeneration

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Perivascular spaces and glymphatic clearance failure in AD

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning KCNK2 in their description or question text

No additional research found