Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CACNA1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CACNA1B is a gene implicated in neurodegeneration research. Key relationships include: associated with, causes, expressed in. Associated with Cancer. Connected to 59 entities in the SciDEX knowledge graph.
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| Gene Symbol | CACNA1B |
| Full Name | Calcium Voltage-Gated Channel Subunit Alpha1 B |
| Chromosome | 9q34.3 |
| Function | of approximately 2339 amino acids |
| Primary Expression | Brain (neurons), Spinal cord, Peripheral nervous system |
| Molecular Weight | 250 kDa |
| Amino Acids | 2339 aa |
| Exons | 47 |
| UniProt ID | Q00962 |
| NCBI Gene ID | 785 |
| Ensembl ID | ENSG00000148438 |
| OMIM | 601314 |
| GeneCards | CACNA1B |
| Human Protein Atlas | CACNA1B |
| Associated Diseases | Alzheimer, Autism, Bipolar, Cancer, Inflammation, Parkinson |
| Interactions | CACNA1H, DRD1, DRD2, GABRA1, GABRB2, GRIA1 |
| KG Connections | 155 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CACNA1B["CACNA1B"]
Cancer{"Cancer"}
CACNA1B -->|"associated with"| Cancer
SCNN1A["SCNN1A"]
CACNA1B -->|"associated with"| SCNN1A
CFTR["CFTR"]
CACNA1B -->|"associated with"| CFTR
PIEZO2["PIEZO2"]
CACNA1B -->|"associated with"| PIEZO2
TRPA1["TRPA1"]
CACNA1B -->|"associated with"| TRPA1
KCNMA1["KCNMA1"]
CACNA1B -->|"associated with"| KCNMA1
TRPV1["TRPV1"]
CACNA1B -->|"associated with"| TRPV1
KCNN4["KCNN4"]
CACNA1B -->|"associated with"| KCNN4
KCNQ1["KCNQ1"]
CACNA1B -->|"associated with"| KCNQ1
CACNA1C["CACNA1C"]
CACNA1B -->|"associated with"| CACNA1C
Oxidative_Phosphorylation(["Oxidative Phosphorylation"])
CACNA1B -->|"associated with"| Oxidative_Phosphorylation
Wnt(["Wnt"])
CACNA1B -->|"associated with"| Wnt
PIEZO1["PIEZO1"]
PIEZO1 -->|"associated with"| CACNA1B
KCNK2["KCNK2"]
KCNK2 -->|"associated with"| CACNA1B
SCN5A["SCN5A"]
SCN5A -->|"associated with"| CACNA1B
TRPM7["TRPM7"]
TRPM7 -->|"associated with"| CACNA1B
SCN1A["SCN1A"]
SCN1A -->|"associated with"| CACNA1B
TRPV4["TRPV4"]
TRPV4 -->|"associated with"| CACNA1B
KCNMA1 -->|"causes"| CACNA1B
KCNQ1 -->|"causes"| CACNA1B
PIEZO1 -->|"causes"| CACNA1B
CANCER["CANCER"]
CANCER -->|"associated with"| CACNA1B
HIPPO["HIPPO"]
HIPPO -->|"associated with"| CACNA1B
CFTR -->|"causes"| CACNA1B
style CACNA1B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Autism | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Schizophrenia | associated_with | disease | 0.65 |
| Bipolar | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| HIPPO | associated_with | gene | 0.60 |
| Wnt | associated_with | pathway | 0.60 |
| PIEZO2 | causes | gene | 0.60 |
| TRPV1 | causes | gene | 0.60 |
| SCN5A | causes | gene | 0.60 |
| Oxidative Phosphorylation | associated_with | pathway | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| SCNN1A | associated_with | gene | 0.60 |
| CFTR | associated_with | gene | 0.60 |
| PIEZO2 | associated_with | gene | 0.60 |
| TRPA1 | associated_with | gene | 0.60 |
| KCNMA1 | associated_with | gene | 0.60 |
| TRPV1 | associated_with | gene | 0.60 |
| KCNN4 | associated_with | gene | 0.60 |
| KCNQ1 | associated_with | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| Axon Guidance | associated_with | pathway | 0.60 |
| SCN1A | causes | gene | 0.60 |
| KCNN4 | causes | gene | 0.60 |
| TRPA1 | causes | gene | 0.60 |
| SCNN1A | causes | gene | 0.60 |
| TCR | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| GENES | causes | gene | 0.60 |
| WNT | associated_with | gene | 0.60 |
| AXON | associated_with | gene | 0.60 |
| TRPV4 | causes | gene | 0.60 |
| KCNQ1 | causes | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| HTR2A | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| CACNA1H | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| DRD1 | associated_with | gene | 0.60 |
| GABRB2 | associated_with | gene | 0.60 |
| CACNA1H | transports | gene | 0.60 |
| SLC1A1 | associated_with | gene | 0.60 |
| GRIA1 | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| DRD2 | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| KCNMA1 | causes | gene | 0.60 |
| KCNQ1 | causes | gene | 0.60 |
| PIEZO1 | causes | gene | 0.60 |
| CFTR | causes | gene | 0.60 |
| SCN1A | causes | gene | 0.60 |
| TRPA1 | causes | gene | 0.60 |
| KCNN4 | causes | gene | 0.60 |
| PIEZO2 | causes | gene | 0.60 |
| SCN5A | causes | gene | 0.60 |
| TRPV4 | causes | gene | 0.60 |
| SCNN1A | causes | gene | 0.60 |
| TRPV1 | causes | gene | 0.60 |
| KCNK2 | causes | gene | 0.60 |
| CACNA1H | transports | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| HTR2A | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| TCR | associated_with | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| CACNA1C | causes | gene | 0.60 |
| WNT | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| PIEZO1 | associated_with | gene | 0.60 |
| KCNK2 | associated_with | gene | 0.60 |
| SCN5A | associated_with | gene | 0.60 |
| TRPM7 | associated_with | gene | 0.60 |
| SCN1A | associated_with | gene | 0.60 |
| TRPV4 | associated_with | gene | 0.60 |
| GABRB2 | associated_with | gene | 0.60 |
| SLC1A1 | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| GRIK4 | associated_with | gene | 0.60 |
| GRIA1 | associated_with | gene | 0.60 |
| DRD1 | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| HIPPO | associated_with | gene | 0.60 |
| AXON | associated_with | gene | 0.60 |
| DRD2 | interacts_with | gene | 0.50 |
| HTR2C | interacts_with | gene | 0.50 |
| DRD1 | interacts_with | gene | 0.50 |
| KCNMA1 | associated_with | gene | 0.50 |
| SCNN1A | associated_with | gene | 0.50 |
| ZO1 | associated_with | gene | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CACNA1B in their description or question text
No additional research found