gene

CACNA1C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNA1C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

220Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CACNA1C is a gene implicated in neurodegeneration research. Key relationships include: associated with, causes, expressed in. Associated with Als, Alzheimer, Anxiety. Connected to 77 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CACNA1C
Aliases	Page for Cav1.2
Function	CACNA1C encodes the alpha-1C subunit of the L-type voltage-gated calcium channel (Cav1.2), one of the most important calcium channels in neurons and cardiac myocytes
Primary Expression	the brain, heart, and smooth muscle
Subcellular Localization	Somatodendritic compartment, dendritic spines, cardiac cells
Molecular Weight	250 kDa
Pathways	Wnt signaling, oxidative stress response
UniProt ID	Q13936
GeneCards	CACNA1C
Human Protein Atlas	CACNA1C
Associated Diseases	Alzheimer, Anxiety, Cancer, Inflammation, Ms, psychiatric disorders
Interactions	APP, CACNA1A, CACNA1D, CACNA1E, cacna1f, CACNA1F
KG Connections	220 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CACNA1C — AlphaFold Q13936 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

Cav1.2 - Voltage-Gated L-Type Calcium Channel (CACNA1C)

protein · 1089 words

→

CACNA1C Gene

gene · 756 words

→

Pathway Diagram

graph TD
    CACNA1C["CACNA1C"] -->|"associated"| Cancer["Cancer"]
    CACNA1C["CACNA1C"] -->|"associated"| Alzheimer["Alzheimer"]
    CACNA1C["CACNA1C"] -->|"associated"| Ms["Ms"]
    CACNA1C["CACNA1C"] -->|"associated"| Inflammation["Inflammation"]
    CACNA1C["CACNA1C"] -.->|"inhibits"| Als["Als"]
    CACNA1C["CACNA1C"] -->|"associated"| Anxiety["Anxiety"]
    PIEZO1["PIEZO1"] -->|"expressed in"| CACNA1C["CACNA1C"]
    KCNK2["KCNK2"] -->|"associated"| CACNA1C["CACNA1C"]
    SCN5A["SCN5A"] -->|"associated"| CACNA1C["CACNA1C"]
    TRPM7["TRPM7"] -->|"associated"| CACNA1C["CACNA1C"]
    style CACNA1C fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (129)

Target	Relation	Type	Str
Cancer	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
ALZHEIMER	therapeutic_target	gene	0.60
GSK3	therapeutic_target	gene	0.60
CACNA2D2	interacts_with	gene	0.60
INS	therapeutic_target	gene	0.60
oxidative stress response	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.60
CFTR	associated_with	gene	0.60
TRPV4	expressed_in	gene	0.60
KCNQ1	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
PIEZO1	expressed_in	gene	0.60
KCNMA1	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
Axon Guidance	associated_with	pathway	0.60
SCN1A	causes	gene	0.60
KCNN4	causes	gene	0.60
TRPA1	causes	gene	0.60
SCNN1A	causes	gene	0.60
PIEZO2	causes	gene	0.60
TRPV1	causes	gene	0.60
SCN5A	causes	gene	0.60
psychiatric disorders	associated_with	disease	0.60
CCS	contributes_to	gene	0.60
CACNA1A	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
KCNN3	associated_with	gene	0.60
CAV1	associated_with	gene	0.60
Pyramidal	associated_with	cell_type	0.60
Nmda Receptor	associated_with	protein	0.60
CACNA1F	interacts_with	gene	0.60
CACNA1G	interacts_with	gene	0.60
CACNA1H	interacts_with	gene	0.60
CACNA1I	interacts_with	gene	0.60
CACNA2D1	interacts_with	gene	0.60
CACNA1B	causes	gene	0.60

Incoming (91)

Source	Relation	Type	Str
CACNB3	participates_in	gene	0.70
RNA	expressed_in	gene	0.60
AND	associated_with	gene	0.60
KCNN4	causes	gene	0.60
PIEZO2	causes	gene	0.60
SCN5A	causes	gene	0.60
SCNN1A	causes	gene	0.60
TRPV1	causes	gene	0.60
KCNK2	causes	gene	0.60
CACNA1B	causes	gene	0.60
CACNA1G	associated_with	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA2D1	associated_with	gene	0.60
GAIN	contributes_to	gene	0.60
CACNA1F	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
CACNA2D2	associated_with	gene	0.60
CACNA1D	associated_with	gene	0.60
APP	interacts_with	gene	0.60
INS	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
APP	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
MMP2	associated_with	gene	0.60
CDK5	associated_with	gene	0.60
CACNA1I	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CACNA1A	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
ESR1	associated_with	gene	0.60
IGF1R	associated_with	gene	0.60
PIEZO1	expressed_in	gene	0.60
KCNK2	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
TRPV4	expressed_in	gene	0.60
CACNA1B	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
KCNMA1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
KCNMA1	causes	gene	0.60
KCNQ1	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CACNA1C in their description or question text

No additional research found