gene

TRPV1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPV1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

235Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

TRPV1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, causes. Associated with Aging, Als, Alzheimer. Connected to 118 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TRPV1
Full Name	Transient Receptor Potential Cation Channel Subfamily V Member 1
Chromosome	17p13.2
Protein Type	Protein
Function	TRPV1 is a capsaicin-activated ion channel that responds to heat and pain stimuli.
Primary Expression	sensory neurons (dorsal root ganglion, trigeminal ganglion), where it functions as a polymodal nociceptor activated by[@caterina2
Pathways	Autophagy
UniProt ID	[Q9Y5Q1](https://www.uniprot.org/uniprotkb/Q9Y5Q1/entry)
GeneCards	TRPV1
Human Protein Atlas	TRPV1
Associated Diseases	Cancer, Ovarian Cancer
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE3, APOE4, APOPTOSIS
KG Connections	235 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TRPV1["TRPV1"]
    TRPV1 -->|"activates"| Inflammation["Inflammation"]
    TRPV1 -->|"activates"| Aging["Aging"]
    TRPV1 -->|"activates"| Ms["Ms"]
    TRPV1 -->|"target for"| Als["Als"]
    TRPV1 -->|"regulates"| P2RY2["P2RY2"]
    TRPV1 -->|"regulates"| FOXP3["FOXP3"]
    TRPV1 -->|"regulates"| TPH2["TPH2"]
    TRPV1 -->|"regulates"| CCL3["CCL3"]
    TRPV1 -->|"target for"| AKT1["AKT1"]
    PANX1["PANX1"] -->|"regulates"| TRPV1
    S100B["S100B"] -->|"regulates"| TRPV1
    RELB["RELB"] -->|"regulates"| TRPV1
    P2RY1["P2RY1"] -->|"regulates"| TRPV1
    CASP3["CASP3"] -->|"regulates"| TRPV1
    SOCS3["SOCS3"] -->|"regulates"| TRPV1
    TRPA1["TRPA1"] -->|"regulates"| TRPV1
    GENES["GENES"] -->|"regulates"| TRPV1
    CXCL2["CXCL2"] -->|"regulates"| TRPV1
    SNAP25["SNAP25"] -->|"regulates"| TRPV1

Outgoing (121)

Target	Relation	Type	Str
nociceptor activation	involved_in	unknown	0.90
Ovarian Cancer	biomarker_for	disease	0.85
Ovarian Cancer	associated_with	disease	0.80
Inflammation	activates	disease	0.75
Cancer	associated_with	disease	0.65
Aging	activates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
Migraine	activates	disease	0.65
Als	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Pain	inhibits	disease	0.65
Parkinson	expressed_in	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Als	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Neuropathy	regulates	disease	0.65
Tauopathy	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Diabetes	regulates	disease	0.65
TAUOPATHY	activates	gene	0.60
MICROGLIA	activates	gene	0.60
Cholesterol	activates	pathway	0.60
Stem Cell	activates	pathway	0.60
Immune Response	activates	pathway	0.60
Macrophage	associated_with	cell_type	0.60
Monocyte	associated_with	cell_type	0.60
Fibroblast	associated_with	cell_type	0.60
NEURON	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Fibroblast	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
RNA	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
Il-1	regulates	protein	0.60
TRPA1	causes	gene	0.60
PIEZO1	causes	gene	0.60
GENES	associated_with	gene	0.60
FERROPTOSIS	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
GENES	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
TRPV4	associated_with	entity	0.60
Neuron	regulates	cell_type	0.60

Incoming (114)

Source	Relation	Type	Str
Resolvin D2	inhibits	unknown	0.95
Frostbite Injury	upregulates	disease	0.90
Resolvin D1	inhibits	unknown	0.90
CB13	downregulates	drug	0.85
lipid raft modification	modulates	unknown	0.85
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
SOCS3	regulates	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
SNAP25	regulates	gene	0.60
P2RX7	regulates	gene	0.60
SYT2	regulates	gene	0.60
TNF	regulates	gene	0.60
SOD2	regulates	gene	0.60
NOS2	regulates	gene	0.60
P2RX3	regulates	gene	0.60
RELA	regulates	gene	0.60
SYP	regulates	gene	0.60
CHRNA7	regulates	gene	0.60
SYT1	regulates	gene	0.60
STAT3	regulates	gene	0.60
HMOX1	regulates	gene	0.60
KCNN4	associated_with	entity	0.60
VEGF	inhibits	gene	0.60
APOE4	inhibits	gene	0.60
PARKINSON	expressed_in	gene	0.60
GFP	inhibits	gene	0.60
NEURON	expressed_in	gene	0.60
PARKINSON'S DISEASE	expressed_in	gene	0.60
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
AND	inhibits	gene	0.60
NLRP3	activates	gene	0.60
PP2A	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
CACNA1B	causes	gene	0.60
CACNA1C	causes	gene	0.60
TRPM7	causes	gene	0.60
IL10	activates	gene	0.60
IL1B	activates	gene	0.60
NOD2	activates	gene	0.60
KCNK2	causes	gene	0.60
SPP1	activates	gene	0.60
TCR	associated_with	gene	0.60
GENES	causes	gene	0.60
CYTOKINES	regulates	gene	0.60
CACNA1C	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRPV1 in their description or question text

No additional research found