gene 1,720 words KG: TRPA1
Contents

TRPA1 Gene

🧬 Gene Info
Gene SymbolTRPA1
Protein TypeProtein
Functionis a calcium-permeable non-selective cation channel characterized by 16-18 ankyrin repeat domains in its N-terminus, making it the most ankyrin-rich TRP channel[@nilius2014].
Molecular Weight108 kDa
Amino Acids959 aa
PathwaysEpigenetic, Nf-Κb, Toll-Like Receptor
UniProt IDSearch UniProt
GeneCardsTRPA1
Human Protein AtlasTRPA1
Associated DiseasesAlzheimer, Cancer, stroke
InteractionsAKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APP
KG Connections256 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.73
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (10)

blarcamesine-axon
clinical_trial · KG edge: associated_with
Astrocytes
entity · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates
AKT1 Gene
gene · KG edge: inhibits
ANG — Angiogenin
gene · KG edge: regulates

Knowledge Graph (12 edges)

TNFA activates TRPA1
PIEZO1 associated_with TRPA1
KCNK2 associated_with TRPA1
SCN5A associated_with TRPA1
TRPM7 associated_with TRPA1
SCN1A associated_with TRPA1
TRPV4 associated_with TRPA1
CACNA1B associated_with TRPA1
SCNN1A associated_with TRPA1
CFTR associated_with TRPA1

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