protein 581 words KG: TRPA1
Contents

TRPA1 Protein

🔬 Protein Info
Gene SymbolTRPA1
Protein TypeProtein
Functionis a calcium-permeable non-selective cation channel characterized by 16-18 ankyrin repeat domains in its N-terminus, making it the most ankyrin-rich TRP channel[@nilius2014].
Molecular Weight108 kDa
Amino Acids959 aa
PathwaysEpigenetic, Nf-Κb, Toll-Like Receptor
UniProt IDSearch UniProt
GeneCardsTRPA1
Human Protein AtlasTRPA1
Associated DiseasesAlzheimer, Cancer, stroke
InteractionsAKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APP
KG Connections256 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (8)

Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (8)

blarcamesine-axon
clinical_trial · KG edge: associated_with
Astrocytes
entity · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates
ANG — Angiogenin
gene · KG edge: regulates
CACNA1B Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TNFA activates TRPA1
PIEZO1 associated_with TRPA1
KCNK2 associated_with TRPA1
SCN5A associated_with TRPA1
TRPM7 associated_with TRPA1
SCN1A associated_with TRPA1
TRPV4 associated_with TRPA1
CACNA1B associated_with TRPA1
SCNN1A associated_with TRPA1
CFTR associated_with TRPA1

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