gene

SCNN1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCNN1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

100Connections

0Hypotheses

0Analyses

46Outgoing

50Incoming

0Experiments

0Debates

Summary

SCNN1A encodes the alpha subunit of the epithelial sodium channel (ENaC), involved in sodium homeostasis, fluid balance, and neuronal function

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🧬 Gene Info

Gene Symbol	SCNN1A
Full Name	Sodium Channel Epithelial Subunit Alpha
Chromosome	12p13.31
Protein Type	Channel
Function	encodes the α-subunit of the epithelial sodium channel (ENaC), also known as the amiloride-sensitive sodium channel
Primary Expression	substantia nigra neurons
UniProt ID	P37088
NCBI Gene ID	6337
Ensembl ID	ENSG00000111319
OMIM	600228
GeneCards	SCNN1A
Human Protein Atlas	SCNN1A
Associated Diseases	Cancer
KG Connections	100 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SCNN1A — AlphaFold P37088 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SCNN1A Gene

gene · 1098 words

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Pathway Diagram

graph TD
    SCNN1A["SCNN1A"]
    Cancer{"Cancer"}
    SCNN1A -->|"associated with"| Cancer
    CFTR["CFTR"]
    SCNN1A -->|"associated with"| CFTR
    PIEZO2["PIEZO2"]
    SCNN1A -->|"associated with"| PIEZO2
    TRPA1["TRPA1"]
    SCNN1A -->|"associated with"| TRPA1
    KCNMA1["KCNMA1"]
    SCNN1A -->|"associated with"| KCNMA1
    TRPV1["TRPV1"]
    SCNN1A -->|"associated with"| TRPV1
    KCNN4["KCNN4"]
    SCNN1A -->|"associated with"| KCNN4
    KCNQ1["KCNQ1"]
    SCNN1A -->|"associated with"| KCNQ1
    CACNA1C["CACNA1C"]
    SCNN1A -->|"associated with"| CACNA1C
    Oxidative_Phosphorylation(["Oxidative Phosphorylation"])
    SCNN1A -->|"associated with"| Oxidative_Phosphorylation
    Wnt(["Wnt"])
    SCNN1A -->|"associated with"| Wnt
    KCNK2["KCNK2"]
    SCNN1A -->|"associated with"| KCNK2
    PIEZO1["PIEZO1"]
    PIEZO1 -->|"associated with"| SCNN1A
    KCNK2 -->|"associated with"| SCNN1A
    SCN5A["SCN5A"]
    SCN5A -->|"associated with"| SCNN1A
    TRPM7["TRPM7"]
    TRPM7 -->|"associated with"| SCNN1A
    SCN1A["SCN1A"]
    SCN1A -->|"associated with"| SCNN1A
    TRPV4["TRPV4"]
    TRPV4 -->|"associated with"| SCNN1A
    CACNA1B["CACNA1B"]
    CACNA1B -->|"associated with"| SCNN1A
    CACNA1C -->|"associated with"| SCNN1A
    CFTR -->|"associated with"| SCNN1A
    KCNQ1 -->|"associated with"| SCNN1A
    TRPA1 -->|"associated with"| SCNN1A
    TRPV1 -->|"associated with"| SCNN1A
    style SCNN1A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

Target	Relation	Type	Str
Cancer	associated_with	disease	0.65
Monocyte	associated_with	cell_type	0.60
Fibroblast	associated_with	cell_type	0.60
PIEZO2	causes	gene	0.60
SCN5A	causes	gene	0.60
SCN1A	causes	gene	0.60
KCNMA1	causes	gene	0.60
KCNN4	causes	gene	0.60
TRPV4	causes	gene	0.60
KCNQ1	causes	gene	0.60
Macrophage	associated_with	cell_type	0.60
CFTR	causes	gene	0.60
Oxidative Phosphorylation	associated_with	pathway	0.60
Wnt	associated_with	pathway	0.60
CACNA1C	associated_with	gene	0.60
GENES	causes	gene	0.60
KCNQ1	associated_with	gene	0.60
TCR	associated_with	gene	0.60
HIPPO	associated_with	gene	0.60
AXON	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
KCNMA1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
Axon Guidance	associated_with	pathway	0.60
TRPV1	causes	gene	0.60
KCNK2	causes	gene	0.60
CACNA1B	causes	gene	0.60
CACNA1C	causes	gene	0.60
TRPM7	causes	gene	0.60
TRPA1	causes	gene	0.60
PIEZO1	causes	gene	0.60
TRPM7	associated_with	entity	0.60
TRPV4	associated_with	entity	0.60
Macrophage	expressed_in	cell_type	0.55
Fibroblast	expressed_in	cell_type	0.55
TRPA1	co_discussed	gene	0.50
CACNA1B	associated_with	gene	0.50
SCN5A	associated_with	gene	0.50
TRPM7	co_discussed	gene	0.50
TRPV1	co_discussed	gene	0.50
TRPV4	co_discussed	gene	0.50
WAS	co_discussed	protein	0.50

Incoming (54)

Source	Relation	Type	Str
TRPV4	causes	gene	0.60
CANCER	associated_with	gene	0.60
HIPPO	associated_with	gene	0.60
AXON	associated_with	gene	0.60
TCR	associated_with	gene	0.60
GENES	causes	gene	0.60
AND	causes	gene	0.60
WNT	associated_with	gene	0.60
PIEZO2	causes	gene	0.60
SCN5A	causes	gene	0.60
GENES	associated_with	gene	0.60
RNA	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
KCNMA1	associated_with	gene	0.60
KCNN4	causes	gene	0.60
KCNK2	causes	gene	0.60
CACNA1B	causes	gene	0.60
CACNA1C	causes	gene	0.60
TRPM7	causes	gene	0.60
TRPV1	causes	gene	0.60
PIEZO1	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
TRPV4	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
KCNMA1	causes	gene	0.60
KCNQ1	causes	gene	0.60
PIEZO1	causes	gene	0.60
CFTR	causes	gene	0.60
SCN1A	causes	gene	0.60
TRPA1	causes	gene	0.60
KCNN4	associated_with	entity	0.60
PIEZO2	associated_with	entity	0.60
KCNN4	co_discussed	gene	0.50
CACNA1B	co_discussed	gene	0.50
CACNA1C	co_discussed	gene	0.50
CFTR	co_discussed	gene	0.50
KCNK2	co_discussed	gene	0.50
KCNQ1	co_discussed	gene	0.50
PIEZO1	co_discussed	gene	0.50
PIEZO2	co_discussed	gene	0.50
SCN1A	co_discussed	gene	0.50
SCN5A	co_discussed	gene	0.50
CANCER	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SCNN1A in their description or question text

No additional research found