gene

KCNMA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNMA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

103Connections

0Hypotheses

0Analyses

50Outgoing

45Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	KCNMA1
Full Name	Potassium Calcium-Activated Channel Subfamily M Alpha 1
Aliases	BK channel, SLO1, KCa1.1
Chromosome	10q22.3
Function	Large-conductance calcium-activated potassium channel (BK channel)
Molecular Weight	126.0 kDa
Amino Acids	1113
Exons	28 exons spanning the coding sequence
Pathways	Potassium transport, Neuronal excitability
UniProt ID	Q12791
Ensembl ID	ENSG00000156113
GeneCards	KCNMA1
Human Protein Atlas	KCNMA1
Genomic Size	~160 kb
Alternative Splicing	Multiple splice variants generate channel diversity [1]
Associated Diseases	Cancer
KG Connections	103 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: KCNMA1 — AlphaFold Q12791 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KCNMA1 Gene

gene · 1671 words

→

KCNMA1 Protein (BK Channel)

protein · 934 words

→

Pathway Diagram

graph TD
    KCNMA1["KCNMA1"] -->|"associated"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    KCNMA1["KCNMA1"] -->|"associated"| TRPV1["TRPV1"]
    style TRPV1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    KCNMA1["KCNMA1"] -->|"associated"| KCNN4["KCNN4"]
    style KCNN4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    KCNMA1["KCNMA1"] -->|"associated"| KCNQ1["KCNQ1"]
    style KCNQ1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    KCNMA1["KCNMA1"] -->|"associated"| CACNA1C["CACNA1C"]
    style CACNA1C fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    KCNMA1["KCNMA1"] -->|"associated"| Oxidative_Phosphorylation["Oxidative Phosphorylation"]
    style Oxidative_Phosphorylation fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    KCNMA1["KCNMA1"] -->|"associated"| Wnt["Wnt"]
    style Wnt fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    PIEZO1["PIEZO1"] -->|"associated"| KCNMA1["KCNMA1"]
    style PIEZO1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    KCNK2["KCNK2"] -->|"associated"| KCNMA1["KCNMA1"]
    style KCNK2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    SCN5A["SCN5A"] -->|"associated"| KCNMA1["KCNMA1"]
    style SCN5A fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    TRPM7["TRPM7"] -->|"associated"| KCNMA1["KCNMA1"]
    style TRPM7 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    SCN1A["SCN1A"] -->|"associated"| KCNMA1["KCNMA1"]
    style SCN1A fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style KCNMA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (58)

Target	Relation	Type	Str
Cancer	associated_with	disease	0.65
SCN1A	causes	gene	0.60
KCNQ1	causes	gene	0.60
PIEZO1	causes	gene	0.60
CFTR	causes	gene	0.60
TRPA1	causes	gene	0.60
KCNN4	causes	gene	0.60
PIEZO2	causes	gene	0.60
SCN5A	causes	gene	0.60
TRPV4	causes	gene	0.60
SCNN1A	causes	gene	0.60
TRPV1	causes	gene	0.60
KCNK2	causes	gene	0.60
CACNA1B	causes	gene	0.60
Axon Guidance	associated_with	pathway	0.60
TRPM7	causes	gene	0.60
PIEZO1	associated_with	entity	0.60
SCN5A	associated_with	entity	0.60
TRPA1	associated_with	entity	0.60
TRPM7	associated_with	entity	0.60
TRPV4	associated_with	entity	0.60
CACNA1C	causes	gene	0.60
CANCER	associated_with	gene	0.60
HIPPO	associated_with	gene	0.60
AXON	associated_with	gene	0.60
TCR	associated_with	gene	0.60
GENES	causes	gene	0.60
AND	causes	gene	0.60
Macrophage	associated_with	cell_type	0.60
Monocyte	associated_with	cell_type	0.60
Fibroblast	associated_with	cell_type	0.60
TRPV1	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
Oxidative Phosphorylation	associated_with	pathway	0.60
Wnt	associated_with	pathway	0.60
Fibroblast	expressed_in	cell_type	0.55
Macrophage	expressed_in	cell_type	0.55
PIEZO2	co_discussed	gene	0.50
SCN1A	co_discussed	gene	0.50
SCN5A	co_discussed	gene	0.50
SCNN1A	co_discussed	gene	0.50
TRPA1	co_discussed	gene	0.50
TRPM7	co_discussed	gene	0.50
KCNQ1	co_discussed	gene	0.50

Incoming (45)

Source	Relation	Type	Str
WNT	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
TRPV4	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
PIEZO1	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
AND	causes	gene	0.60
HIPPO	associated_with	gene	0.60
GENES	causes	gene	0.60
TCR	associated_with	gene	0.60
AXON	associated_with	gene	0.60
GENES	associated_with	gene	0.60
RNA	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
PIEZO1	causes	gene	0.60
KCNK2	causes	gene	0.60
KCNQ1	causes	gene	0.60
CFTR	causes	gene	0.60
TRPV4	causes	gene	0.60
CACNA1B	causes	gene	0.60
TRPA1	causes	gene	0.60
TRPV1	causes	gene	0.60
PIEZO2	causes	gene	0.60
SCN5A	causes	gene	0.60
SCNN1A	causes	gene	0.60
SCN1A	causes	gene	0.60
CACNA1C	causes	gene	0.60
KCNN4	causes	gene	0.60
TRPM7	causes	gene	0.60
CACNA1C	associated_with	gene	0.60
GENES	co_discussed	gene	0.50
CANCER	co_discussed	gene	0.50
CACNA1B	co_discussed	gene	0.50
CACNA1C	co_discussed	gene	0.50
CFTR	co_discussed	gene	0.50
KCNK2	co_discussed	gene	0.50
ZO1	associated_with	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNMA1 in their description or question text

No additional research found