gene

SCN1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCN1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

167Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SCN1A is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, causes. Associated with Aging, Als, Autism. Connected to 99 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SCN1A
Chromosome	2q24.3
Primary Expression	Brain (neurons, particularly GABAergic interneurons), heart
Molecular Weight	226 kDa
Amino Acids	2000 aa
UniProt ID	P35499
NCBI Gene ID	6335
Ensembl ID	ENSG00000144285
OMIM	182389
GeneCards	SCN1A
Human Protein Atlas	SCN1A
Associated Diseases	Als, Cancer, Epilepsy
Interactions	GENES, PVALB, SNAP25
KG Connections	167 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SCN1A — AlphaFold P35499 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SCN1A["SCN1A"]
    SCN1A -->|"target for"| Aging["Aging"]
    SCN1A -->|"target for"| Als["Als"]
    SCN1A -->|"target for"| Neuroinflammation["Neuroinflammation"]
    SCN1A -->|"target for"| Epilepsy["Epilepsy"]
    SCN1A -->|"target for"| Autism["Autism"]
    SCN1A -->|"target for"| Ms["Ms"]
    SCN1A -->|"target for"| Inflammation["Inflammation"]
    SCN1A -->|"regulates"| Cardiac["Cardiac"]
    SCN1A -->|"target for"| MTOR["MTOR"]
    SCN1A -->|"target for"| RELN["RELN"]
    DHX9["DHX9"] -->|"target for"| SCN1A
    KCNT1["KCNT1"] -->|"target for"| SCN1A
    KCNQ2["KCNQ2"] -->|"target for"| SCN1A
    GENES["GENES"] -->|"target for"| SCN1A
    RYR2["RYR2"] -->|"regulates"| SCN1A
    KCNMA1["KCNMA1"] -->|"causes"| SCN1A
    KCNQ1["KCNQ1"] -->|"causes"| SCN1A
    PIEZO1["PIEZO1"] -->|"causes"| SCN1A
    CFTR["CFTR"] -->|"causes"| SCN1A

Outgoing (95)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.75
Aging	therapeutic_target	disease	0.75
Epigenetic	therapeutic_target	pathway	0.70
Epilepsy	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiac	regulates	disease	0.65
Autism	therapeutic_target	disease	0.65
Epilepsy	associated_with	disease	0.65
RAS	therapeutic_target	gene	0.60
Chaperone	therapeutic_target	pathway	0.60
EPILEPSY	associated_with	gene	0.60
AND	associated_with	gene	0.60
HUB GENES	associated_with	gene	0.60
ERK	therapeutic_target	gene	0.60
HIPPO	associated_with	gene	0.60
TRPM7	causes	gene	0.60
SCN5A	associated_with	entity	0.60
TRPM7	associated_with	entity	0.60
CANCER	associated_with	gene	0.60
TRPV4	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
KCNMA1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
Axon Guidance	associated_with	pathway	0.60
MTOR	therapeutic_target	gene	0.60
RELN	therapeutic_target	gene	0.60
STXBP1	therapeutic_target	gene	0.60
SYNGAP1	therapeutic_target	gene	0.60
ROBO1	associated_with	gene	0.60
GAD2	regulates	gene	0.60
PIK3CB	regulates	gene	0.60
NOS1	regulates	gene	0.60
CFTR	regulates	gene	0.60
EPHB4	associated_with	gene	0.60
MMP2	associated_with	gene	0.60
HIP1R	regulates	gene	0.60
TRPA1	causes	gene	0.60
KCNN4	causes	gene	0.60

Incoming (72)

Source	Relation	Type	Str
GENES	therapeutic_target	gene	0.60
TCR	associated_with	gene	0.60
AXON	associated_with	gene	0.60
AND	causes	gene	0.60
GENES	causes	gene	0.60
WNT	associated_with	gene	0.60
CFTR	causes	gene	0.60
STXBP1	therapeutic_target	gene	0.60
PVALB	associated_with	gene	0.60
RNA	associated_with	gene	0.60
DHX9	therapeutic_target	gene	0.60
KCNT1	therapeutic_target	gene	0.60
KCNQ2	therapeutic_target	gene	0.60
KCNMA1	causes	gene	0.60
KCNQ1	causes	gene	0.60
PIEZO1	causes	gene	0.60
GENES	associated_with	gene	0.60
HIPPO	associated_with	gene	0.60
EPILEPSY	therapeutic_target	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
ERK	therapeutic_target	gene	0.60
RAS	therapeutic_target	gene	0.60
PIEZO2	associated_with	entity	0.60
TRPA1	causes	gene	0.60
TRPV1	causes	gene	0.60
PIEZO2	causes	gene	0.60
SCN5A	causes	gene	0.60
SCNN1A	causes	gene	0.60
SNAP25	associated_with	gene	0.60
KCNN4	causes	gene	0.60
CDKL5	associated_with	gene	0.60
HCN1	associated_with	gene	0.60
KCNQ2	associated_with	gene	0.60
PLCB1	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
PVALB	interacts_with	gene	0.60
PIEZO1	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
TRPV4	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
KCNMA1	associated_with	gene	0.60
RYR2	regulates	gene	0.60
KCNK2	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SCN1A in their description or question text

No additional research found

SCN1A

Understanding Entity Pages

Summary

Wiki Pages (5)

SCN1A Gene

SCN1A Gene

SCN1A

Roche/Neurocrine SCN1A AAV Gene Therapy — Dravet Syndrome

Sodium Channel Nav1.1 (SCN1A) Protein

Pathway Diagram

Outgoing (95)

Incoming (72)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Experiments (0)

Related Papers (0)

Debates (0)

Related Research