disease

Migraine

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Migraine: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

236Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Migraine is a disease characterized by neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with Aging, Als, Alzheimer. Connected to 123 entities in the SciDEX knowledge graph.

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Disease Info

HTR1A	Autoreceptor (somatodendritic) controlling firing rate
HTR1B	Autoreceptor (terminal) inhibiting release
HTR2A	Postsynaptic excitatory receptor
HTR2C	Postsynaptic receptor modulating pain and mood
HTR7	Postsynaptic excitatory receptor in circadian regulation
Associated Genes	ALZHEIMER, ALZHEIMER'S DISEASE, AND, CDK4, CHD4, Chemokine, DEPRESSION, EP300
Therapeutic Agents	Niacin
KG Connections	202 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Longitudinal Mechanism Study

experiment · 760 words

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Pathway Diagram

graph TD
    Migraine["Migraine"] -->|"associated"| Oxidative_Stress["Oxidative Stress"]
    Migraine["Migraine"] -->|"associated"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    Migraine["Migraine"] -->|"associated"| Huntington["Huntington"]
    Migraine["Migraine"] -->|"associated"| Inflammation["Inflammation"]
    Migraine["Migraine"] -->|"associated"| Ms["Ms"]
    Migraine["Migraine"] -->|"associated"| Autism["Autism"]
    Oxidative_stress["Oxidative stress"] -->|"causes"| Migraine["Migraine"]
    Cerebral_energy_deficiency["Cerebral energy deficiency"] -->|"causes"| Migraine["Migraine"]
    Cerebral_energy_metabolism["Cerebral energy metabolism"] -->|"associated"| Migraine["Migraine"]
    CCL3["CCL3"] -->|"activates"| Migraine["Migraine"]
    style Migraine fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (75)

Target	Relation	Type	Str
CHOLESTEROL	regulates	phenotype	0.65
Inflammation	activates	disease	0.65
NEURODEGENERATION	interacts_with	disease	0.65
Angiogenesis	activates	pathway	0.60
NEURODEGENERATION	causes	disease	0.60
Pi3K/Akt	activates	pathway	0.60
Blood-Brain Barrier	activates	pathway	0.60
Synaptic Plasticity	activates	pathway	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
ferroptosis	involves	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Blood-Brain Barrier	associated_with	pathway	0.60
Notch	contributes_to	pathway	0.60
unfolded protein response	involves	pathway	0.60
neurons	affects	cell_type	0.60
SCHIZOPHRENIA	inhibits	entity	0.60
nitric oxide	disrupts	neurotransmitter	0.60
Apoptosis	activates	pathway	0.60
MULTIPLE SCLEROSIS	activates	disease	0.60
Amyloid	activates	pathway	0.55
Astrocyte	regulates	cell_type	0.55
Glaucoma	activates	disease	0.55
Circadian Rhythm	activates	pathway	0.55
Circadian Rhythm	therapeutic_target	pathway	0.55
Dementia	contributes_to	disease	0.55
Cholesterol	activates	pathway	0.55
Inflammation	associated_with	disease	0.55
Ms	associated_with	disease	0.55
Alzheimer	therapeutic_target	disease	0.55
Calcium Signaling	associated_with	pathway	0.55
Cell Cycle	associated_with	pathway	0.55
Macrophage	associated_with	cell_type	0.55
Neutrophil	associated_with	cell_type	0.55
Dendritic Cell	associated_with	cell_type	0.55
Huntington	associated_with	disease	0.55
Autism	associated_with	disease	0.55
Parkinson	associated_with	disease	0.55
Multiple Sclerosis	associated_with	disease	0.55
Alzheimer	activates	disease	0.55
Neurodegeneration	activates	disease	0.55
Inflammasome	activates	pathway	0.55
Ferroptosis	regulates	pathway	0.55
Calcium Signaling	regulates	pathway	0.55
Neuroinflammatory	regulates	pathway	0.55
Cell Cycle	regulates	pathway	0.55
Neuron	activates	cell_type	0.55
Microglia	activates	cell_type	0.55
METFORMIN	inhibits	concept	0.50
Type 1 Diabetes	activates	disease	0.50
DIABETES	activates	disease	0.50

Incoming (161)

Source	Relation	Type	Str
EPHA5	associated_with	gene	0.80
INFLAMMATION	activates	gene	0.75
Niacin	treats	drug	0.75
RPL17	associated_with	gene	0.70
Oxidative stress	causes	process	0.70
Cerebral energy deficiency	causes	process	0.70
Cerebral energy metabolism	associated_with	process	0.70
MITOPHAGY	associated_with	gene	0.65
TRPA1	inhibits	gene	0.65
SRC	regulates	gene	0.65
SCN8A	inhibits	gene	0.65
AKT1	inhibits	gene	0.65
TRPM3	inhibits	gene	0.65
CREBBP	inhibits	gene	0.65
CYTOKINES	regulates	gene	0.65
TNF	associated_with	gene	0.65
INFLAMMATION	regulates	gene	0.65
IL-6	associated_with	gene	0.65
NEUROINFLAMMATION	regulates	gene	0.65
TNF-Α	associated_with	gene	0.65
MICROGLIA	activates	gene	0.65
BDNF	activates	gene	0.65
TRKB	activates	gene	0.65
CX3CR1	activates	gene	0.65
ALZHEIMER'S DISEASE	associated_with	gene	0.65
NEUROINFLAMMATION	activates	gene	0.65
OVERVIEW	associated_with	gene	0.65
GENES	activates	gene	0.65
TAU	activates	gene	0.65
NEURODEGENERATION	activates	gene	0.65
PI3K	activates	gene	0.65
ALZHEIMER	activates	gene	0.65
AMYLOID	activates	gene	0.65
AMYLOID-BETA	activates	gene	0.65
ALZHEIMER'S DISEASE	activates	gene	0.65
AKT	activates	gene	0.65
TNF	regulates	gene	0.65
Als	activates	disease	0.65
NAD	activates	gene	0.65
GPR109A	activates	gene	0.65
LDL	activates	gene	0.65
FERROPTOSIS	associated_with	gene	0.65
NEUROTOXICITY	activates	gene	0.65
GABA	activates	gene	0.65
GABA-A	activates	gene	0.65
INFLAMMATION	associated_with	gene	0.65
CIRCADIAN RHYTHM	therapeutic_target	gene	0.65
CLOCK	therapeutic_target	gene	0.65
CCL3	activates	gene	0.65
C1Q	activates	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning Migraine in their description or question text

No additional research found

Migraine

Understanding Entity Pages

Summary

Wiki Pages (4)

Serotonergic Raphe Neurons in Migraine

Migraine

Raphe Serotonergic Neurons in Migraine

Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Longitudinal Mechanism Study

Pathway Diagram

Outgoing (75)

Incoming (161)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Experiments (0)

Related Papers (0)

Debates (0)

Related Research