gene

P2RY2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2RY2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

67Connections

0Hypotheses

0Analyses

31Outgoing

36Incoming

0Experiments

0Debates

Summary

P2RY2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Aging, Inflammation, Ms. Connected to 31 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	P2RY2
Full Name	Purinergic Receptor P2Y2
Chromosome	11q13.2
Protein Family	P2Y receptor family (GPCR)
Protein Type	Receptor
Function	is a unique member of the P2Y receptor family because it is activated by both ATP and UTP with similar potency, making it a central sensor of cellular stress and tissue damage.
Molecular Weight	43 kDa
Exons	2
UniProt ID	Q9ULL8
NCBI Gene ID	5029
Ensembl ID	ENSG00000165326
OMIM	173415
GeneCards	P2RY2
Human Protein Atlas	P2RY2
Associated Diseases	epilepsy
KG Connections	67 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: P2RY2 — AlphaFold Q9ULL8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

P2RY2 (Purinergic Receptor P2Y2)

gene · 2602 words

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Pathway Diagram

graph TD
    P2RY2["P2RY2"]
    Inflammation{"Inflammation"}
    P2RY2 -->|"activates"| Inflammation
    Aging{"Aging"}
    P2RY2 -->|"activates"| Aging
    Ms{"Ms"}
    P2RY2 -->|"activates"| Ms
    FOXP3["FOXP3"]
    P2RY2 -->|"regulates"| FOXP3
    TPH2["TPH2"]
    P2RY2 -->|"regulates"| TPH2
    CCL3["CCL3"]
    P2RY2 -->|"regulates"| CCL3
    neurodegeneration["neurodegeneration"]
    P2RY2 -->|"implicated in"| neurodegeneration
    PANX1["PANX1"]
    PANX1 -->|"regulates"| P2RY2
    S100B["S100B"]
    S100B -->|"regulates"| P2RY2
    RELB["RELB"]
    RELB -->|"regulates"| P2RY2
    P2RY1["P2RY1"]
    P2RY1 -->|"regulates"| P2RY2
    CASP3["CASP3"]
    CASP3 -->|"regulates"| P2RY2
    SOCS3["SOCS3"]
    SOCS3 -->|"regulates"| P2RY2
    TRPA1["TRPA1"]
    TRPA1 -->|"regulates"| P2RY2
    GENES["GENES"]
    GENES -->|"regulates"| P2RY2
    CXCL2["CXCL2"]
    CXCL2 -->|"regulates"| P2RY2
    SNAP25["SNAP25"]
    SNAP25 -->|"regulates"| P2RY2
    P2RX7["P2RX7"]
    P2RX7 -->|"regulates"| P2RY2
    SYT2["SYT2"]
    SYT2 -->|"regulates"| P2RY2
    style P2RY2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (31)

Target	Relation	Type	Str
Inflammation	activates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Epilepsy	associated_with	disease	0.65
PER	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
SYNAPSE	associated_with	gene	0.60
Astrocyte	associated_with	cell_type	0.60
MICROGLIA	associated_with	gene	0.60
Microglia	associated_with	cell_type	0.60
Neuron	associated_with	cell_type	0.60
EPILEPSY	associated_with	gene	0.60
astrocytes	expressed_in	cell_type	0.60
MGLUR1	associated_with	gene	0.60
CD68	associated_with	gene	0.60
epilepsy	associated_with	disease	0.60
AND	associated_with	gene	0.60
TPH2	regulates	gene	0.60
CCL3	regulates	gene	0.60
P2RY1	associated_with	gene	0.60
NEURON	associated_with	gene	0.60
FOXP3	regulates	gene	0.60
epilepsy	regulates	disease	0.60
Astrocyte	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
Astrocyte	regulates	cell_type	0.50
GLIOSIS	regulates	concept	0.50
MGLUR1	regulates	protein	0.50
MGLUR5	regulates	protein	0.50
MGLUR5	associated_with	protein	0.50

Incoming (36)

Source	Relation	Type	Str
ASTROCYTE	associated_with	gene	0.60
P2RY1	associated_with	gene	0.60
MGLUR5	associated_with	gene	0.60
SYNAPSE	associated_with	gene	0.60
EPILEPSY	associated_with	gene	0.60
MGLUR1	associated_with	gene	0.60
GENES	regulates	gene	0.60
ANTIOXIDANT GENES	regulates	gene	0.60
PER	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
SOCS3	regulates	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
SNAP25	regulates	gene	0.60
P2RX7	regulates	gene	0.60
SYT2	regulates	gene	0.60
TNF	regulates	gene	0.60
SOD2	regulates	gene	0.60
NOS2	regulates	gene	0.60
P2RX3	regulates	gene	0.60
RELA	regulates	gene	0.60
SYP	regulates	gene	0.60
CHRNA7	regulates	gene	0.60
SYT1	regulates	gene	0.60
STAT3	regulates	gene	0.60
HMOX1	regulates	gene	0.60
TRPV1	regulates	gene	0.60
EPILEPSY	regulates	gene	0.50
CD68	co_expressed_with	protein	0.50
P2RY1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning P2RY2 in their description or question text

No additional research found