gene

PIEZO2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIEZO2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

232Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for PIEZO2 — Piezo Type Mechanosensitive Ion Channel Component 2

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🧬 Gene Info

Gene Symbol	PIEZO2
Full Name	Piezo Type Mechanosensitive Ion Channel Component 2
Chromosome	18p11.22
Protein Type	Channel
Function	encodes a 2822-amino acid protein that forms functional homotrimeric channels.
Primary Expression	a highly cell-type-specific pattern in the nervous system:
Molecular Weight	318 kDa
Amino Acids	2822 aa
Pathways	Apoptosis, Autophagy
UniProt ID	Q9H5I5
NCBI Gene ID	63895
Ensembl ID	ENSG00000154864
OMIM	613629
GeneCards	PIEZO2
Human Protein Atlas	PIEZO2
Associated Diseases	Als, Cancer, Cardiac, FIBROSIS, Labor Dysfunction, Ms
Interactions	AND, ANG, FAM38A, GENES, PIEZO, PIEZO1
KG Connections	232 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PIEZO2 — AlphaFold Q9H5I5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PIEZO2 — Piezo Type Mechanosensitive Ion Channel Component 2

gene · 1377 words

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PIEZO2 Protein

protein · 1072 words

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Pathway Diagram

graph TD
    PIEZO2["PIEZO2"]
    PIEZO2 -->|"participates in"| MA_CATION_CHANNELS["MA_CATION_CHANNELS"]
    PIEZO2 -->|"expressed in"| DRG_NEURONS["DRG_NEURONS"]
    PIEZO2 -->|"regulates"| pain["pain"]
    PIEZO2 -->|"regulates"| touch_sensation["touch_sensation"]
    PIEZO2 -->|"regulates"| proprioception["proprioception"]
    PIEZO2 -->|"target for"| Ms["Ms"]
    PIEZO2 -->|"regulates"| Senescence["Senescence"]
    PIEZO2 -->|"regulates"| Inflammation["Inflammation"]
    FAM38B["FAM38B"] -->|"encodes"| PIEZO2
    PIEZO1["PIEZO1"] -->|"activates"| PIEZO2
    GJA1["GJA1"] -->|"target for"| PIEZO2
    FAM38A["FAM38A"] -->|"activates"| PIEZO2
    GENES["GENES"] -->|"activates"| PIEZO2
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| PIEZO2
    INFLAMMATION["INFLAMMATION"] -->|"regulates"| PIEZO2
    YAP1["YAP1"] -->|"activates"| PIEZO2

Outgoing (145)

Target	Relation	Type	Str
mechanotransduction	involved_in	process	0.98
uterine contractions	associated_with	phenotype	0.95
Parturition	involved_in	process	0.95
Uterine Contractions	involved_in	phenotype	0.95
Proprioception	mediates	process	0.95
Uterine Contractions	mediates	phenotype	0.95
Pain Sensation	mediates	process	0.95
Mechanical Forces	involved_in	process	0.92
Cardiac Fibrosis	contributes_to	disease	0.92
parturition	mediates	process	0.92
uterine smooth muscle cells	expressed_in	cell_type	0.90
Cardiac Fibroblast Autophagy	regulates	process	0.90
Labor Progression	associated_with	process	0.90
Mechanical Forces	mediates	process	0.90
labor dysfunction	therapeutic_target	disease	0.88
Labor Dysfunction	associated_with	disease	0.88
Fibroblast Activation	activates	process	0.88
Cardiac Fibroblast	expressed_in	cell_type	0.87
GJA1	regulates	gene	0.85
Ovarian Cancer	biomarker_for	disease	0.85
Ovarian Cancer	associated_with	disease	0.85
GJA1	upregulates	gene	0.85
Sensory Neurons	expressed_in	cell_type	0.85
MA_CATION_CHANNELS	participates_in	protein	0.72
proprioception	regulates	phenotype	0.72
touch_sensation	regulates	phenotype	0.72
pain	regulates	phenotype	0.72
DRG_NEURONS	expressed_in	cell_type	0.72
Ms	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Als	inhibits	disease	0.65
Neuroblastoma	activates	disease	0.65
Aging	interacts_with	disease	0.65
Senescence	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Inflammation	regulates	disease	0.65
Ms	associated_with	disease	0.65
Fibrosis	activates	disease	0.65
Als	activates	disease	0.65
Als	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Cardiac	activates	disease	0.65
Als	associated_with	disease	0.65
nervous_system	expressed_in	cell_type	0.64
TRPV4	associated_with	entity	0.60
PIEZO1	causes	gene	0.60
RNA	expressed_in	gene	0.60
CANCER	associated_with	gene	0.60
AND	activates	gene	0.60

Incoming (87)

Source	Relation	Type	Str
YTHDF1	regulates	protein	0.95
YTHDF1	binds	protein	0.95
m6A Modification	modulates	mechanism	0.93
TGF-β1	upregulates	protein	0.85
FAM38B	encodes	gene	0.80
PIEZO1	associated_with	gene	0.70
PIEZO	activates	gene	0.60
RNA	regulates	gene	0.60
GJA1	associated_with	gene	0.60
GJA1	causes	gene	0.60
KCNK2	causes	gene	0.60
TRPV4	causes	gene	0.60
CACNA1B	causes	gene	0.60
CACNA1C	causes	gene	0.60
TRPM7	causes	gene	0.60
SCNN1A	causes	gene	0.60
AND	activates	gene	0.60
FAM38A	activates	gene	0.60
GENES	activates	gene	0.60
FAM38B	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
TRPV4	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
PIEZO1	regulates	gene	0.60
KCNN4	associated_with	entity	0.60
SCN5A	causes	gene	0.60
TCR	associated_with	gene	0.60
GENES	causes	gene	0.60
PIEZO	interacts_with	gene	0.60
KCNK2	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
GENES	associated_with	gene	0.60
PIEZO	inhibits	gene	0.60
PIEZO1	activates	gene	0.60
GJA1	therapeutic_target	gene	0.60
AXON	associated_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
POSTN	activates	gene	0.60
CANCER	associated_with	gene	0.60
HIPPO	associated_with	gene	0.60
WNT	associated_with	gene	0.60
RNA	associated_with	gene	0.60
AND	causes	gene	0.60
RNA	activates	gene	0.60
GENETIC MUTATIONS	regulates	gene	0.60
AND	regulates	gene	0.60
PIEZO	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PIEZO2 in their description or question text

No additional research found