concept

AXON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AXON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1229Connections

8Hypotheses

0Analyses

50Outgoing

50Incoming

10Experiments

0Debates

Summary

AXON is a concept in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, Aging, Als. Connected to 388 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	AXON
Key Genes/Proteins	ACHE, Actin, ADNP, AGING, AKT, Albumin
Related Diseases	Aging, Als, ALS, Alzheimer, Alzheimer'S Disease
Related Pathways	Akt

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

blarcamesine-axon

clinical_trial · 2860 words

→

Pathway Diagram

graph TD
    AXON["AXON"]
    AXON -->|"causes"| ALS["ALS"]
    AXON -->|"activates"| Cancer["Cancer"]
    AXON -->|"causes"| Inflammation["Inflammation"]
    AXON -->|"causes"| Aging["Aging"]
    AXON -->|"activates"| Neuroinflammation["Neuroinflammation"]
    AXON -->|"stabilizes"| JUN["JUN"]
    AXON -->|"expressed in"| NEURON["NEURON"]
    CDK5["CDK5"] -->|"causes"| AXON
    CANCER["CANCER"] -->|"activates"| AXON
    HIPPO["HIPPO"] -->|"activates"| AXON
    G3BP1["G3BP1"] -->|"activates"| AXON
    NEURON -->|"activates"| AXON
    INFLAMMATION["INFLAMMATION"] -->|"causes"| AXON
    HSP90["HSP90"] -->|"activates"| AXON
    ROS["ROS"] -->|"activates"| AXON

Outgoing (771)

Target	Relation	Type	Str
Als	activates	disease	0.95
astrocytes	found_in	cell_type	0.90
neurons	found_in	cell_type	0.90
neural stem cells	found_in	cell_type	0.90
oligodendrocytes	found_in	cell_type	0.90
Neurodegeneration	causes	disease	0.85
Cancer	activates	disease	0.85
microglia	found_in	cell_type	0.80
spinal cord	enriched_in	brain_region	0.80
unfolded protein response	involved_in	pathway	0.80
hippocampus	enriched_in	brain_region	0.80
NEURON	activates	gene	0.80
NEURON	causes	gene	0.80
CANCER	activates	gene	0.80
NEURODEGENERATION	causes	gene	0.80
Parkinson	regulates	disease	0.75
Amyotrophic Lateral Sclerosis	activates	disease	0.75
Alzheimer	regulates	disease	0.75
Alzheimer	activates	disease	0.75
Inflammation	activates	disease	0.75
ALS	causes	disease	0.75
Tumor	activates	disease	0.75
Multiple Sclerosis	associated_with	disease	0.75
Als	regulates	disease	0.75
ALZHEIMER	regulates	gene	0.70
MICROGLIA	associated_with	gene	0.70
PARKINSON	regulates	gene	0.70
Mapk	activates	pathway	0.70
AKT	regulates	gene	0.70
AXON REGENERATION	associated_with	gene	0.70
Schwann cells	found_in	cell_type	0.70
Oxidative Stress	activates	pathway	0.70
ALZHEIMER	activates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
NEURODEGENERATIVE DISEASES	associated_with	gene	0.70
TRAK1	interacts_with	gene	0.70
interneurons	found_in	cell_type	0.70
MTOR	associated_with	gene	0.70
Mtor	associated_with	pathway	0.70
ALZHEIMER'S DISEASE	activates	gene	0.70
cortex	enriched_in	brain_region	0.70
AXON REGENERATION	activates	gene	0.70
macrophages	found_in	cell_type	0.70
white matter	enriched_in	brain_region	0.70
BRAIN INJURY	associated_with	gene	0.70
DNA	activates	gene	0.70
NEURON	associated_with	gene	0.70
pyramidal neurons	found_in	cell_type	0.70
AKT	activates	gene	0.70
INFLAMMATION	activates	gene	0.70

Incoming (458)

Source	Relation	Type	Str
neurodegeneration	disrupts	disease	0.90
TAU	expressed_in	entity	0.90
MAPT	expressed_in	protein	0.90
TRAK1	expressed_in	protein	0.90
aging	disrupts	disease	0.80
Alzheimer's disease	disrupts	disease	0.80
autism	disrupts	disease	0.80
neuroinflammation	disrupts	disease	0.80
multiple sclerosis	disrupts	disease	0.80
MAP6	expressed_in	protein	0.80
BDNF	activates	gene	0.70
NAD	regulates	gene	0.70
NAD	activates	gene	0.70
SARM1	activates	gene	0.70
ALS	disrupts	disease	0.70
spinal muscular atrophy	disrupts	disease	0.70
ROS	activates	gene	0.70
RNA	interacts_with	gene	0.70
Parkinson's disease	disrupts	disease	0.70
BDNF	inhibits	gene	0.70
NORMAL TENSION GLAUCOMA	activates	gene	0.60
AND	interacts_with	gene	0.60
OPTN	inhibits	gene	0.60
AXONAL MITOCHONDRIAL TRANSPORT	interacts_with	gene	0.60
ALS	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
MICROTUBULES	interacts_with	gene	0.60
CD8	associated_with	gene	0.60
AND	associated_with	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
EPHB3	interacts_with	gene	0.60
OPTINEURIN	activates	gene	0.60
DEPRESSION	regulates	gene	0.60
C1Q	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	protects_against	gene	0.60
EXOSOMES	protects_against	gene	0.60
ALS	protects_against	gene	0.60
C1Q	protects_against	gene	0.60
MOTOR NEURONS	protects_against	gene	0.60
SOD1	protects_against	gene	0.60
SYN2A	activates	gene	0.60
ACHE	activates	gene	0.60
GAP43	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MANF	activates	gene	0.60
AXON REGENERATION	activates	gene	0.60
MICROGLIA	activates	gene	0.60
DENDRITE	associated_with	gene	0.60
DEMENTIA	regulates	gene	0.60
DLK	causes	gene	0.60

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Granzyme B Inhibition with Serpina3n to Preserve Axonal Inte	0.698	neuroimmunology	Do CXCL10-recruited CD8+ T cells provide
SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D	0.698	neurodegeneration	What is the molecular mechanism by which
Axonal RNA Transport Reconstitution	0.695	neurodegeneration	RNA binding protein dysregulation across
STMN2 Restoration as a Prerequisite for Axon Growth After TD	0.683	neurodegeneration	What molecular mechanisms enable functio
Stathmin-2 Splice Switching to Prevent Axonal Degeneration A	0.664	neurodegeneration	RNA binding protein dysregulation across

Axonal Transport Defect: C9orf72 hexanucleotide expansion im	0.660	neurodegeneration	What are the neuron-specific effects of
A genetically encoded reporter for axonal mitochondrial prot	0.540	neuroscience	How can subcellular compartmentalization
Synaptic-Selective Autophagy Receptor Expression to Bypass A	0.416	proteomics	Quantitative proteomics of the aging syn

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Temporal analysis showing mitochondrial defects precede other p	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
s:** - Single-cell RNA-seq to measure editing efficiency across differ	falsification	ALS	0.400	0.50	cell_line	proposed	$150,000
ALS Progression Rate Heterogeneity — mechanism and biomarker predictor	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
ALS Regional Onset and Spread: Network-Level Staging Model	clinical	ALS	0.400	0.50	human	proposed	$7,500,000
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
Axonal Transport Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Environmental Exposure Causal Attribution in ALS — Experiment Design	validation	ALS	0.400	0.50	human	proposed	$3,000,000
Frontal and Temporal Lobe Selective Vulnerability in FTD — Mechanisms	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation re [PMID:36593966]	Li B, Xin Z, Gao S, Li Y, Guo S, Fu Y, X	Theranostics	2023	1
Multisystem proteinopathy: Where myopathy and motor neuron disease converge. [PMID:33145792]	Korb MK, Kimonis VE, Mozaffar T	Muscle Nerve	2021	1
The role of m6A modification in the biological functions and diseases. [PMID:33611339]	Jiang X, Liu B, Nie Z, Duan L, Xiong Q,	Signal Transduct Target Ther	2021	1
Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liv [PMID:33213490]	Senlin Zhao, Yushuai Mi, Bingjie Guan, B	Journal of hematology & oncolo	2020	1
Rare Inherited forms of Paget's Disease and Related Syndromes. [PMID:30756140]	Ralston SH, Taylor JP	Calcif Tissue Int	2019	1
A LNK-CBL-HNRPA2B1-GPX4 signaling axis mediates dopaminergic neuron vulnerabilit [PMID:41616574]	["Liu Z", "Wang R", "Shen M", "Lan X", "	Redox biology	2026	0
Human papillomavirus 16 E6 oncoprotein promotes up-regulation of RNA-binding pro [PMID:41725810]	["Cerasuolo A", "Pecchillo Cimmino T", "	Frontiers in microbiology	2026	0
Molecular recognition and induced dimerization of hnRNP A2/B1 truncations by G-q [PMID:41888191]	["Shahatibieke D", "Tang X", "Zheng X",	Scientific reports	2026	0
LncRNA 4930544M13Rik-201 regulates CACNA2D1 expression via interacting with hnRN [PMID:41864512]	Fang Z, Liu F, Tang Q, Liu Y, Peng Y, Zh	Brain research bulletin	2026	0
Comparative Binding Analysis by Computational Methods and Quartz Crystal Microba [PMID:41728844]	["Volkova O", "Serova A", "Kravtsov V",	Journal of chemical informatio	2026	0
Functional Variants of the RAD51 Gene Contribute to Susceptibility to Non-Syndro [PMID:41918261]	Guo S, Guo T, Xu Y, Chen R, Wang X	Orthodontics & craniofacial re	2026	0
Ligand-specific conformational dynamics and interaction landscapes of hnRNPA2B1 [PMID:41853685]	Zhou Z, Li Y, Yang P, Zhu R, Li J, Wu B,	Current research in structural	2026	0
Neddylation-Mediated hnRNPA2B1 Degradation Aggravates Retinal Endothelial Cell D [PMID:41773772]	Chen TR, Zhou JX, Hou YR, Zhang YN, Li C	Investigative ophthalmology &	2026	0
Mechanistic studies on HNRNPA2B1 suggest binding but not selective recognition o [PMID:41662154]	["Park R", "Demny M", "Miller L", "Pedra	RNA biology	2026	0
Network medicine modeling of the m⁶A regulatory landscape identifies a KLF6-WTAP [PMID:41787499]	Xu C, Zhou Z, Lin Y, Zhang S, Cai S, Li	Journal of translational medic	2026	0
Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergi [PMID:41507195]	["Jin Y", "Cao Y", "Ma W", "Li R", "Li Y	Nature communications	2026	0
The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatic [PMID:41725222]	["Xu W", "Shi L", "Lu A", "Cui L", "Qian	Immunity, inflammation and dis	2026	0
Expression, purification, and biophysical characterization of liquid-liquid phas [PMID:41297573]	["Dur\u00e1n-Armenta L", "Meszaros A", "	Protein expression and purific	2026	0
Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progre [PMID:34453888]	Jiang L, Lin W, Zhang C, Ash PEA, Verma	Molecular cell	2021	0
Stress granule mediated protein aggregation and underlying gene defects in the F [PMID:31626953]	Baradaran-Heravi Y, Van Broeckhoven C, v	Neurobiology of disease	2020	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AXON in their description or question text