protein

SMN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

115Connections

0Hypotheses

0Analyses

50Outgoing

39Incoming

0Experiments

0Debates

Summary

Page for SMN Protein

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🔬 Protein Info

Gene Symbol	SMN
Chromosome	5q13.2.
Function	SMN is essential for cellular viability, and complete absence is embryonically lethal.
Primary Expression	Spinal Cord, Ca1, Cerebellum
Molecular Weight	38 kDa
Amino Acids	294 aa
Exons	2
Pathways	Tdp-43, Apoptosis, Er Stress, Cell Cycle, CRISPR-Cas
GeneCards	SMN
Human Protein Atlas	SMN
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, dementia, frontotemporal
Interactions	Actin, ALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, CHMP7, MOTOR NEURONS
KG Connections	115 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SMN["SMN"]
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    SMN -->|"interacts with"| Amyotrophic_Lateral_Sclerosis
    Aging["Aging"]
    SMN -->|"interacts with"| Aging
    ALS["ALS"]
    SMN -->|"associated with"| ALS
    Neurodegeneration["Neurodegeneration"]
    SMN -->|"expressed in"| Neurodegeneration
    Dementia["Dementia"]
    SMN -->|"associated with"| Dementia
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    SMN -->|"associated with"| Amyotrophic_Lateral_Sclerosis
    Frontotemporal_Dementia["Frontotemporal Dementia"]
    SMN -->|"associated with"| Frontotemporal_Dementia
    ALS["ALS"]
    SMN -->|"activates"| ALS
    Tdp_43["Tdp-43"]
    SMN -->|"interacts with"| Tdp_43
    SMN2["SMN2"]
    SMN -->|"associated with"| SMN2
    GENES["GENES"]
    SMN -->|"expressed in"| GENES
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    SMN -->|"associated with"| AMYOTROPHIC_LATERAL_SCLEROSIS
    TIA1["TIA1"]
    SMN -->|"associated with"| TIA1
    CNTN4["CNTN4"]
    SMN -->|"expressed in"| CNTN4
    Tdp_43["Tdp-43"]
    SMN -->|"associated with"| Tdp_43
    Apoptosis["Apoptosis"]
    SMN -->|"expressed in"| Apoptosis
    Er_Stress["Er Stress"]
    SMN -->|"associated with"| Er_Stress
    Cell_Cycle["Cell Cycle"]
    SMN -->|"expressed in"| Cell_Cycle
    FUS["FUS"]
    FUS -->|"co expressed with"| SMN
    STMN2["STMN2"]
    STMN2 -->|"interacts with"| SMN
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    AMYOTROPHIC_LATERAL_SCLEROSIS -->|"interacts with"| SMN
    TDP_43["TDP-43"]
    TDP_43 -->|"interacts with"| SMN
    MOTOR_NEURONS["MOTOR NEURONS"]
    MOTOR_NEURONS -->|"interacts with"| SMN
    SMD1["SMD1"]
    SMD1 -->|"interacts with"| SMN
    RNA["RNA"]
    RNA -->|"interacts with"| SMN
    AND["AND"]
    AND -->|"activates"| SMN
    NEURON["NEURON"]
    NEURON -->|"interacts with"| SMN
    CHMP7["CHMP7"]
    CHMP7 -->|"interacts with"| SMN
    AND["AND"]
    AND -->|"interacts with"| SMN
    SMN1["SMN1"]
    SMN1 -->|"causes"| SMN

Outgoing (76)

Target	Relation	Type	Str
CHMP7	regulates	protein	0.95
neurons	expressed_in	cell_type	0.80
Spinal Muscular Atrophy	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Spinal Muscular Atrophy	causes	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Spinal Muscular Atrophy	associated_with	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Aging	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
ALS	associated_with	disease	0.65
NEURON	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
RNA SPLICING	interacts_with	gene	0.60
MOTOR NEURONS	interacts_with	gene	0.60
TPRKB	expressed_in	gene	0.60
Raf	expressed_in	protein	0.60
dementia	associated_with	disease	0.60
AND	activates	gene	0.60
TBC1D24	encodes	gene	0.60
BID	encodes	gene	0.60
PLIN4	expressed_in	gene	0.60
HNRNPA1	associated_with	gene	0.60
CDKN1A	expressed_in	gene	0.60
ATXN2	associated_with	gene	0.60
FUS	associated_with	gene	0.60
ER stress	associated_with	process	0.60
neurodegeneration	expressed_in	disease	0.60
ALS	activates	gene	0.60
Tdp-43	interacts_with	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
CNTN4	expressed_in	gene	0.60
TDP-43	interacts_with	gene	0.60
CHMP7	interacts_with	gene	0.60
SMN1	causes	gene	0.60
ALDH1A2	expressed_in	gene	0.60
CCNF	encodes	gene	0.60
frontotemporal dementia	associated_with	disease	0.60
TIA1	associated_with	gene	0.60
NEURON	interacts_with	gene	0.60
SMD1	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
Stem Cell	activates	cell_type	0.60
Neuron	interacts_with	cell_type	0.60
Actin	interacts_with	protein	0.60
Ras	associated_with	protein	0.60
ALS	causes	disease	0.60

Incoming (39)

Source	Relation	Type	Str
ALS	activates	gene	0.60
ALS	interacts_with	gene	0.60
CHMP7	interacts_with	gene	0.60
FUS	co_expressed_with	protein	0.60
STMN2	interacts_with	gene	0.60
TDP-43	interacts_with	gene	0.60
TBC1D24	expressed_in	gene	0.60
PLIN4	expressed_in	gene	0.60
FUS	associated_with	gene	0.60
ATXN2	associated_with	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
BID	expressed_in	gene	0.60
HNRNPA1	associated_with	gene	0.60
CCNF	expressed_in	gene	0.60
TDP-43	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
CDKN1A	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
MOTOR NEURONS	expressed_in	gene	0.60
NEURON	causes	gene	0.60
SMN1	causes	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
MOTOR NEURONS	interacts_with	gene	0.60
SMD1	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
NEURON	expressed_in	gene	0.60
NEURON	associated_with	gene	0.60
ALS	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
TPRKB	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
ALDH1A2	expressed_in	gene	0.60
PLIN4	encodes	gene	0.60
CNTN4	encodes	gene	0.60
CHMP7	activates	gene	0.60
HNRNPA2B1	co_expressed_with	gene	0.50
MAPT	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SMN in their description or question text

No additional research found

SMN

Understanding Entity Pages

Summary

Wiki Pages (7)

Survival Motor Neuron (SMN)

SMN1 - Survival Motor Neuron 1

SMN2 Gene

SMN2 Protein

SMN1 Protein

SMNDC1 Gene

SMN Protein