gene

MATR3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MATR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

120Connections

0Hypotheses

1Analyses

50Outgoing

43Incoming

0Experiments

1Debates

Summary

MATR3 is a gene implicated in neurodegeneration research. Key relationships include: associated with, contributes to, activates. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 73 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MATR3
Function	Matr3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Subcellular Localization	Signals (NLS): Two NLS sequences for nuclear import - C-terminal domain**: M
Molecular Weight	125 kDa
Amino Acids	847 aa
Pathways	Autophagy, Proteasome, Dna Repair, autophagy pathway
GeneCards	MATR3
Human Protein Atlas	MATR3
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Dementia, frontotemporal dementia
Interactions	ALS, AMYOTROPHIC LATERAL SCLEROSIS, App, AUTOPHAGY, CCNF, CHCHD10
KG Connections	120 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

MATR3 Protein

protein · 1155 words

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MATR3 Gene

gene · 820 words

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Pathway Diagram

graph TD
    MATR3["MATR3"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    MATR3 -->|"associated with"| Amyotrophic_Lateral_Sclerosis
    ALS{"ALS"}
    MATR3 -->|"associated with"| ALS
    Frontotemporal_Dementia{"Frontotemporal Dementia"}
    MATR3 -->|"associated with"| Frontotemporal_Dementia
    Dementia{"Dementia"}
    MATR3 -->|"associated with"| Dementia
    Neurodegeneration{"Neurodegeneration"}
    MATR3 -->|"associated with"| Neurodegeneration
    MATR3 -->|"activates"| ALS
    MATR3 -->|"activates"| Neurodegeneration
    TIA1["TIA1"]
    MATR3 -->|"degrades"| TIA1
    HNRNPA2B1["HNRNPA2B1"]
    MATR3 -->|"degrades"| HNRNPA2B1
    MATR3 -->|"contributes to"| TIA1
    MATR3 -->|"contributes to"| HNRNPA2B1
    VALOSIN["VALOSIN"]
    MATR3 -->|"associated with"| VALOSIN
    HNRNPA1["HNRNPA1"]
    HNRNPA1 -->|"degrades"| MATR3
    VALOSIN -->|"associated with"| MATR3
    NEURON["NEURON"]
    NEURON -->|"associated with"| MATR3
    GENES["GENES"]
    GENES -->|"associated with"| MATR3
    OPTN["OPTN"]
    OPTN -->|"degrades"| MATR3
    VCP["VCP"]
    VCP -->|"associated with"| MATR3
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"associated with"| MATR3
    OPTINEURIN["OPTINEURIN"]
    OPTINEURIN -->|"degrades"| MATR3
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"associated with"| MATR3
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"degrades"| MATR3
    JUN["JUN"]
    JUN -->|"activates"| MATR3
    RANKL["RANKL"]
    RANKL -->|"activates"| MATR3
    style MATR3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (77)

Target	Relation	Type	Str
Multisystem Proteinopathy	causes	disease	0.90
Amyotrophic Lateral Sclerosis	associated_with	disease	0.80
ALS	associated_with	disease	0.75
FUS	interacts_with	protein	0.75
GENES	associated_with	gene	0.70
Neurodegeneration	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
ALS	activates	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Osteoclast	activates	cell_type	0.60
NEK1	interacts_with	gene	0.60
TBK1	interacts_with	gene	0.60
frontotemporal dementia	implicated_in	disease	0.60
RNA	interacts_with	gene	0.60
HNRNPA1	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
RNA	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
TIA1	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
NEK1	associated_with	gene	0.60
CHCHD10	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
C21ORF2	associated_with	gene	0.60
SOD1	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
Dna Repair	therapeutic_target	pathway	0.60
Neuron	associated_with	cell_type	0.60
SQSTM1	degrades	gene	0.60
TNFRSF11A	activates	gene	0.60
HNRNPA2B1	contributes_to	gene	0.60
HNRNPA2B1	implicated_in	gene	0.60
NEURON	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
FUS	contributes_to	gene	0.60
TARDBP	contributes_to	gene	0.60
MOTOR NEURONS	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
RANKL	activates	gene	0.60
Rb	associated_with	protein	0.60
App	activates	protein	0.60
autophagy pathway	participates_in	pathway	0.60
T cells	expressed_in	cell_type	0.60

Incoming (43)

Source	Relation	Type	Str
HNRNPA2B1	degrades	gene	0.60
TIA1	degrades	gene	0.60
C9ORF72	contributes_to	gene	0.60
OPTINEURIN	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
RNA	associated_with	gene	0.60
RNA	degrades	gene	0.60
AND	degrades	gene	0.60
TNFRSF11B	activates	gene	0.60
FUS	implicated_in	gene	0.60
DNA	interacts_with	gene	0.60
HNRNPA1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
GENES	associated_with	gene	0.60
VCP	associated_with	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
TIA1	associated_with	gene	0.60
ALS	associated_with	gene	0.60
HNRNPA1	degrades	gene	0.60
VALOSIN	associated_with	gene	0.60
NEURON	associated_with	gene	0.60
OPTN	degrades	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
OPTINEURIN	degrades	gene	0.60
DEMENTIA	associated_with	gene	0.60
SQSTM1	degrades	gene	0.60
JUN	activates	gene	0.60
RANKL	activates	gene	0.60
GAIN	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
RANK	activates	gene	0.60
CHCHD10	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
CCNF	interacts_with	gene	0.60
ALS2	associated_with	gene	0.60
CNTN4	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
HNRNPA1	causes	gene	0.60
HNRNPA2B1	causes	gene	0.60
AND	associated_with	gene	0.60
TNFRSF11A	activates	gene	0.60
HNRNPA2B1	co_expressed_with	gene	0.50
HNRNPA1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do the seven novel ALS genes function in animal models to cause neurodegener

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.724

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The authors explicitly state that the effects of these novel genes (MATR3, CHCHD

closed · Rounds: 4 · Score: 0.71 · 2026-04-14

Related Research

Hypotheses and analyses mentioning MATR3 in their description or question text

No additional research found