gene

RRAGB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RRAGB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

50Connections

0Hypotheses

0Analyses

25Outgoing

25Incoming

0Experiments

0Debates

Summary

RRAGB is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, implicated in. Associated with ALS, Aging, Als. Connected to 42 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RRAGB
Full Name	Ras-Related GTP Binding B
Chromosome	Xq12
Function	encodes a member of the Rag GTPase family that plays a critical role in amino acid sensing and the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway.
Amino Acids	313 aa
Pathways	mTOR, mtor
UniProt ID	Q9NQQ5
NCBI Gene ID	10671
Ensembl ID	ENSG00000147434
GeneCards	RRAGB
Human Protein Atlas	RRAGB
N-terminal domain	GTP/GDP binding domain with Switch I and Switch II regions that undergo conformational changes between active (GTP-bound) and inactive (GDP-bound) states
GTPase domain	Catalyzes GTP hydrolysis, regulated by GAPs (GTPase-activating proteins) and GEFs (guanine nucleotide exchange factors)
C-terminal region	Involved in heterodimer formation with RRAGA
Guanine nucleotide exchange	The Ragulator complex, anchored to the lysosomal membrane, acts as a GEF for RagA/B, promoting the GTP-bound (active) state in response to amino acid presence.
Associated Diseases	Neurodegeneration, X-linked Intellectual Disability, Parkinson's Disease
Interactions	AND, ATF4, ATG, ATG8, AUTOPHAGY, CANCER
KG Connections	50 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RRAGB — AlphaFold Q9NQQ5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RRAGB — Ras-Related GTP Binding B

gene · 2988 words

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Pathway Diagram

graph TD
    RRAGB["RRAGB"]
    Cancer{"Cancer"}
    RRAGB -->|"interacts with"| Cancer
    Aging{"Aging"}
    RRAGB -->|"interacts with"| Aging
    Ms{"Ms"}
    RRAGB -->|"interacts with"| Ms
    Als{"Als"}
    RRAGB -->|"interacts with"| Als
    RRAGB -->|"regulates"| Aging
    RRAGB -->|"regulates"| Cancer
    ALS{"ALS"}
    RRAGB -->|"interacts with"| ALS
    TIA1["TIA1"]
    RRAGB -->|"interacts with"| TIA1
    EIF2A["EIF2A"]
    RRAGB -->|"interacts with"| EIF2A
    Mtor(["Mtor"])
    RRAGB -->|"interacts with"| Mtor
    Er_Stress(["Er Stress"])
    RRAGB -->|"interacts with"| Er_Stress
    Autophagy(["Autophagy"])
    RRAGB -->|"interacts with"| Autophagy
    GABARAP["GABARAP"]
    GABARAP -->|"interacts with"| RRAGB
    ATF4["ATF4"]
    ATF4 -->|"interacts with"| RRAGB
    FMR1["FMR1"]
    FMR1 -->|"interacts with"| RRAGB
    MTOR["MTOR"]
    MTOR -->|"interacts with"| RRAGB
    RRAGA["RRAGA"]
    RRAGA -->|"interacts with"| RRAGB
    G3BP1["G3BP1"]
    G3BP1 -->|"interacts with"| RRAGB
    JUN["JUN"]
    JUN -->|"interacts with"| RRAGB
    MAPT["MAPT"]
    MAPT -->|"interacts with"| RRAGB
    ATG["ATG"]
    ATG -->|"interacts with"| RRAGB
    EIF2A -->|"interacts with"| RRAGB
    TIA1 -->|"interacts with"| RRAGB
    ATF4 -->|"regulates"| RRAGB
    style RRAGB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

Target	Relation	Type	Str
Cancer	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Aging	regulates	disease	0.65
Cancer	regulates	disease	0.65
Autophagy	regulates	pathway	0.60
Er Stress	regulates	pathway	0.60
LYSOSOME	interacts_with	gene	0.60
ATG8	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
ATF4	interacts_with	gene	0.60
Mtor	interacts_with	pathway	0.60
Er Stress	interacts_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60
TIA1	interacts_with	gene	0.60
GABA	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
TAU	interacts_with	gene	0.60
LYSOSOME	activates	gene	0.50

Incoming (25)

Source	Relation	Type	Str
GABARAP	interacts_with	gene	0.60
ATF4	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
RRAGA	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
JUN	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
ATG8	interacts_with	gene	0.60
LGALS8	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
TAU	interacts_with	gene	0.60
ATG	regulates	gene	0.60
EIF2A	interacts_with	gene	0.60
TIA1	interacts_with	gene	0.60
ATF4	regulates	gene	0.60
MTOR	activates	entity	0.60
RRAGA	activates	entity	0.60
NUFIP2	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
mTOR	activates	entity	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RRAGB in their description or question text

No additional research found