gene

RANKL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RANKL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

152Connections

0Hypotheses

0Analyses

50Outgoing

35Incoming

0Experiments

0Debates

Summary

RANKL is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Aging, Als. Connected to 98 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RANKL (TNFSF11)
Full Name	Tumor Necrosis Factor Ligand Superfamily Member 11
Aliases	TNFSF11
Chromosome	13q14
Function	RANKL is a type II transmembrane protein that can exist in both membrane-bound and soluble forms[@lacey1998].
Primary Expression	various tissues: - High Expression: Lymph nodes, thymus, bone marrow, spleen - Moderate Expression: Heart, skeletal muscle, brain - Cellular
Pathways	NF-κB
UniProt ID	O14788
NCBI Gene ID	9600
Ensembl ID	ENSG00000120659
OMIM	602642
Osteoclast Formation	RANKL binds to RANK on osteoclast precursors, triggering the NF-κB, c-Fos, and NFATc1 signaling cascades that drive differentiation into mature osteoclasts[@kong1999]
Bone Remodeling	The RANKL/OPG ratio determines bone resorption rates
Pathological Bone Loss	Elevated RANKL contributes to conditions like osteoporosis and rheumatoid arthritis
T Cell Co-stimulation	RANKL provides critical co-stimulatory signals for T cell activation and survival[@josien1999]
Associated Diseases	Als, neurodegeneration
Known Drugs/Compounds	Urolithin A
Interactions	Actin, AGING, AKT, AND, APOPTOSIS, App
KG Connections	152 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RANKL — AlphaFold O14788 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RANKL (TNFSF11)

gene · 678 words

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Pathway Diagram

graph TD
    RANKL["RANKL"]
    RANKL -->|"activates"| osteoclastogenesis["osteoclastogenesis"]
    RANKL -->|"activates"| RANK["RANK"]
    RANKL -->|"activates"| Neurodegeneration["Neurodegeneration"]
    RANKL -->|"activates"| Ms["Ms"]
    RANKL -->|"activates"| Als["Als"]
    RANKL -->|"target for"| Cancer["Cancer"]
    RANKL -->|"activates"| Senescence["Senescence"]
    RANKL -->|"activates"| Inflammation["Inflammation"]
    RANKL -->|"activates"| Tumor["Tumor"]
    Urolithin_A["Urolithin A"] -->|"inhibits"| RANKL
    OPG["OPG"] -->|"inhibits"| RANKL
    VCP["VCP"] -->|"activates"| RANKL
    JUN["JUN"] -->|"activates"| RANKL
    SQSTM1["SQSTM1"] -->|"activates"| RANKL
    RANK -->|"activates"| RANKL
    ATF4["ATF4"] -->|"regulates"| RANKL
    GAIN["GAIN"] -->|"activates"| RANKL
    HNRNPA2B1["HNRNPA2B1"] -->|"activates"| RANKL
    HNRNPA1["HNRNPA1"] -->|"activates"| RANKL

Outgoing (117)

Target	Relation	Type	Str
RANK	binds	protein	0.95
osteoclastogenesis	activates	phenotype	0.90
Osteoclastogenesis	upregulates	biological_process	0.80
RANK	regulates	gene	0.80
Senescence	activates	disease	0.75
Inflammation	activates	disease	0.75
Aging	activates	disease	0.75
Osteoporosis	activates	disease	0.75
RANK	activates	protein	0.72
Differentiation	activates	pathway	0.70
ALS	activates	disease	0.65
ALS	regulates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Ms	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Als	associated_with	disease	0.65
Als	inhibits	disease	0.65
Senescence	inhibits	disease	0.65
Tumor	regulates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Actin	activates	protein	0.60
App	activates	protein	0.60
App	regulates	protein	0.60
EXOSOMES	inhibits	gene	0.60
App	inhibits	protein	0.60
oxidative stress response	participates_in	pathway	0.60
CDK4	activates	gene	0.60
TXNRD1	inhibits	gene	0.60
NFATC1	activates	gene	0.60
SLC7A11	activates	gene	0.60
SHH	activates	gene	0.60
MAOA	activates	gene	0.60
PI3K	inhibits	gene	0.60
AKT	inhibits	gene	0.60
TRAF6	inhibits	gene	0.60
NFATC1	inhibits	gene	0.60
CSF2	inhibits	gene	0.60
Wnt	regulates	pathway	0.60
RUNX2	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
TNF-Α	regulates	gene	0.60
AGING	activates	gene	0.60
Stem Cell	activates	pathway	0.60
Oxidative Stress	activates	pathway	0.60

Incoming (35)

Source	Relation	Type	Str
Urolithin A	inhibits	drug	0.90
TNF	regulates	gene	0.70
OPG	inhibits	protein	0.64
TRAF6	associated_with	gene	0.60
BECLIN1	inhibits	gene	0.60
RANK	inhibits	gene	0.60
HNRNPA1	associated_with	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
IL6	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
WNT	regulates	gene	0.60
AND	regulates	gene	0.60
ATF4	regulates	gene	0.60
JUN	activates	gene	0.60
GAIN	activates	gene	0.60
HNRNPA2B1	activates	gene	0.60
HNRNPA1	activates	gene	0.60
ATF4	therapeutic_target	gene	0.60
TNF	activates	gene	0.60
GENES	activates	gene	0.60
RUNX2	regulates	gene	0.60
VCP	activates	gene	0.60
CYTOKINES	regulates	gene	0.60
SQSTM1	activates	gene	0.60
RANK	activates	gene	0.60
RANK	regulates	gene	0.60
RANK	interacts_with	entity	0.60
TIA1	activates	gene	0.60
FGF23	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
TNFRSF11A	activates	gene	0.60
MATR3	activates	gene	0.60
AND	activates	gene	0.60
TNFRSF11B	activates	gene	0.60
MATR3	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RANKL in their description or question text

No additional research found