gene

PLIN4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLIN4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

86Connections

0Hypotheses

0Analyses

50Outgoing

21Incoming

0Experiments

0Debates

Summary

Perilipin 4 (PLIN4) is a lipid droplet-associated protein involved in lipid storage and metabolism, with emerging roles in neurobiology and neurodegenerative diseases including Alzheimer's and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	PLIN4
Function	encodes a member of the perilipin family of proteins that are essential regulators of lipid droplet formation, storage, and mobilization.
Primary Expression	neurons and glial cells, where they participate in lipid droplet dynamics relevant to neurodegenerative processes in Alzheimer's disease (AD), Parkins
Molecular Weight	50 kDa
Amino Acids	456 aa
Ensembl ID	ENSG00000146383
GeneCards	PLIN4
Human Protein Atlas	PLIN4
PLIN1-3	Emerged in vertebrates with the appearance of adipose tissue
PLIN4	Conserved in mammals with highest expression in adipocytes
PLIN5	Evolutionarily ancient, present in all vertebrates
Direct binding	Hydrophobic interactions with the lipid droplet surface
Protein-protein interactions	Associates with other perilipin family members
Phosphorylation regulation	Post-translational modifications modulate droplet association
Adipose tissue	Highest expression in white and brown adipose tissue
Associated Diseases	neurodegeneration
Interactions	BCL2, CARD14, MITOPHAGY, TBC1D24
KG Connections	86 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PLIN4 Gene

gene · 1879 words

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Pathway Diagram

graph TD
    PLIN4["PLIN4"]
    Neurodegeneration{"Neurodegeneration"}
    PLIN4 -->|"protects_against"| Neurodegeneration
    Alzheimer{"Alzheimer"}
    PLIN4 -->|"protects_against"| Alzheimer
    BDNF["BDNF"]
    PLIN4 -->|"protects_against"| BDNF
    AMYLOID["AMYLOID"]
    PLIN4 -->|"protects_against"| AMYLOID
    BCL2["BCL2"]
    PLIN4 -->|"inhibits"| BCL2
    GENES["GENES"]
    PLIN4 -->|"protects_against"| GENES
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    PLIN4 -->|"protects_against"| ALZHEIMER_S_DISEASE
    CARD14["CARD14"]
    PLIN4 -->|"inhibits"| CARD14
    APP["APP"]
    PLIN4 -->|"protects_against"| APP
    Mitophagy(["Mitophagy"])
    PLIN4 -->|"inhibits"| Mitophagy
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"inhibits"| PLIN4
    TAU["TAU"]
    TAU -->|"protects_against"| PLIN4
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"protects_against"| PLIN4
    FGF2["FGF2"]
    FGF2 -->|"protects_against"| PLIN4
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"protects_against"| PLIN4

Outgoing (65)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Spinal Muscular Atrophy	expressed_in	disease	0.65
Als	encodes	disease	0.65
Amyotrophic Lateral Sclerosis	encodes	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Frontotemporal Dementia	expressed_in	disease	0.65
Frontotemporal Dementia	encodes	disease	0.65
Dementia	encodes	disease	0.65
TPRKB	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
Tdp-43	expressed_in	pathway	0.60
Cell Cycle	expressed_in	pathway	0.60
ALS	encodes	gene	0.60
DEMENTIA	encodes	gene	0.60
TPRKB	encodes	gene	0.60
APOPTOSIS	encodes	gene	0.60
CNTN4	expressed_in	gene	0.60
GENES	protects_against	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
Mitophagy	inhibits	pathway	0.60
APOPTOSIS	expressed_in	gene	0.60
ALS	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
Er Stress	expressed_in	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
Neuron	expressed_in	cell_type	0.60
SMN	encodes	gene	0.60
CCNF	encodes	gene	0.60
BID	encodes	gene	0.60
Er Stress	encodes	pathway	0.60
Cell Cycle	encodes	pathway	0.60
Apoptosis	encodes	pathway	0.60
Neuron	encodes	cell_type	0.60
Tdp-43	encodes	protein	0.60
Raf	expressed_in	protein	0.60
BDNF	protects_against	gene	0.60
BCL2	inhibits	gene	0.60
CARD14	inhibits	gene	0.60
APP	protects_against	gene	0.60
BID	expressed_in	gene	0.60
HNRNPA2B1	expressed_in	gene	0.60
TDP-43	expressed_in	gene	0.60
TBC1D24	expressed_in	gene	0.60
MAPT	expressed_in	gene	0.60

Incoming (21)

Source	Relation	Type	Str
NEURON	encodes	gene	0.60
NEURON	expressed_in	gene	0.60
ALS	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
TAU	protects_against	gene	0.60
FGF2	protects_against	gene	0.60
TBC1D24	expressed_in	gene	0.60
FUS	encodes	gene	0.60
MITOPHAGY	inhibits	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
ALZHEIMER	protects_against	gene	0.60
ATXN2	expressed_in	gene	0.60
HNRNPA1	expressed_in	gene	0.60
CNTN4	expressed_in	gene	0.60
BID	expressed_in	gene	0.60
CCNF	expressed_in	gene	0.60
MAPT	expressed_in	gene	0.60
HNRNPA2B1	expressed_in	gene	0.60
SMN	expressed_in	gene	0.60
TIA1	expressed_in	gene	0.60
TBC1D24	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PLIN4 in their description or question text

No additional research found