gene

CNTN4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CNTN4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections

0Hypotheses

0Analyses

47Outgoing

30Incoming

0Experiments

0Debates

Summary

Contactin 4 (CNTN4) is a GPI-anchored neural cell adhesion molecule of the immunoglobulin superfamily encoded by the CNTN4 gene at chromosomal locus 3p26.2. CNTN4 plays critical roles in neuronal development, axon guidance, synapse formation, and neural circuit assembly. Variants and deletions in CNTN4 have been strongly implicated in autism spectrum disorder, intellectual disability, and other neurodevelopmental disorders through disruption of synaptic adhesion complexes with NRXN1 and related

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🧬 Gene Info

Gene Symbol	CNTN4
Full Name	Contactin 4
Chromosome	3
Protein Family	Immunoglobulin superfamily; Contactin family
Protein Type	GPI-anchored neural cell adhesion molecule
Function	is a GPI-anchored protein that localizes to lipid rafts in neuronal membranes where it mediates cell surface interactions essential for neural circuit formation and maintenance [@pmid_15342350].
Primary Expression	Brain (cortex, hippocampus, cerebellum), peripheral tissues
Molecular Weight	~116 kDa
Amino Acids	028 aa
Exons	24
UniProt ID	Q9C0A2
NCBI Gene ID	55299
Ensembl ID	ENSG00000144619
GeneCards	CNTN4
Human Protein Atlas	CNTN4
Associated Diseases	ALS, Amyotrophic Lateral Sclerosis
KG Connections	77 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CNTN4 — AlphaFold Q9C0A2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CNTN4 — Contactin 4

gene · 4497 words

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Pathway Diagram

graph TD
    CNTN4["CNTN4"]
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    CNTN4 -->|"expressed in"| Amyotrophic_Lateral_Sclerosis
    Als["Als"]
    CNTN4 -->|"expressed in"| Als
    Dementia["Dementia"]
    CNTN4 -->|"expressed in"| Dementia
    Frontotemporal_Dementia["Frontotemporal Dementia"]
    CNTN4 -->|"expressed in"| Frontotemporal_Dementia
    PLIN4["PLIN4"]
    CNTN4 -->|"expressed in"| PLIN4
    BID["BID"]
    CNTN4 -->|"expressed in"| BID
    APOPTOSIS["APOPTOSIS"]
    CNTN4 -->|"expressed in"| APOPTOSIS
    ALS["ALS"]
    CNTN4 -->|"expressed in"| ALS
    HNRNPA2B1["HNRNPA2B1"]
    CNTN4 -->|"expressed in"| HNRNPA2B1
    TDP_43["TDP-43"]
    CNTN4 -->|"expressed in"| TDP_43
    TBC1D24["TBC1D24"]
    CNTN4 -->|"expressed in"| TBC1D24
    MAPT["MAPT"]
    CNTN4 -->|"expressed in"| MAPT
    NEURON["NEURON"]
    CNTN4 -->|"expressed in"| NEURON
    DEMENTIA["DEMENTIA"]
    CNTN4 -->|"expressed in"| DEMENTIA
    CDKN1A["CDKN1A"]
    CNTN4 -->|"expressed in"| CDKN1A
    TIA1["TIA1"]
    CNTN4 -->|"expressed in"| TIA1
    FUS["FUS"]
    CNTN4 -->|"expressed in"| FUS
    Er_Stress["Er Stress"]
    CNTN4 -->|"expressed in"| Er_Stress
    Apoptosis["Apoptosis"]
    CNTN4 -->|"expressed in"| Apoptosis
    Neuron["Neuron"]
    CNTN4 -->|"expressed in"| Neuron
    Tdp_43["Tdp-43"]
    CNTN4 -->|"expressed in"| Tdp_43
    Cell_Cycle["Cell Cycle"]
    CNTN4 -->|"expressed in"| Cell_Cycle
    ATXN2["ATXN2"]
    ATXN2 -->|"expressed in"| CNTN4
    HNRNPA1["HNRNPA1"]
    HNRNPA1 -->|"expressed in"| CNTN4
    TBC1D24["TBC1D24"]
    TBC1D24 -->|"expressed in"| CNTN4
    PLIN4["PLIN4"]
    PLIN4 -->|"expressed in"| CNTN4
    FUS["FUS"]
    FUS -->|"expressed in"| CNTN4
    HNRNPA2B1["HNRNPA2B1"]
    HNRNPA2B1 -->|"expressed in"| CNTN4
    BID["BID"]
    BID -->|"expressed in"| CNTN4
    NEURON["NEURON"]
    NEURON -->|"expressed in"| CNTN4

Outgoing (47)

Target	Relation	Type	Str
ALS	associated_with	disease	0.70
Dementia	expressed_in	disease	0.65
Spinal Muscular Atrophy	expressed_in	disease	0.65
Als	encodes	disease	0.65
Amyotrophic Lateral Sclerosis	encodes	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Frontotemporal Dementia	encodes	disease	0.65
Frontotemporal Dementia	expressed_in	disease	0.65
Dementia	encodes	disease	0.65
CCNF	encodes	gene	0.60
TBC1D24	encodes	gene	0.60
BID	encodes	gene	0.60
DISC1	associated_with	gene	0.60
SETX	associated_with	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
ALS	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
Er Stress	expressed_in	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
Neuron	expressed_in	cell_type	0.60
Tdp-43	expressed_in	pathway	0.60
Cell Cycle	expressed_in	pathway	0.60
TPRKB	encodes	gene	0.60
APOPTOSIS	encodes	gene	0.60
MATR3	associated_with	gene	0.60
BID	expressed_in	gene	0.60
HNRNPA2B1	expressed_in	gene	0.60
TDP-43	expressed_in	gene	0.60
TBC1D24	expressed_in	gene	0.60
MAPT	expressed_in	gene	0.60
CDKN1A	expressed_in	gene	0.60
TIA1	expressed_in	gene	0.60
FUS	expressed_in	gene	0.60
SMN	encodes	gene	0.60
Neuron	encodes	cell_type	0.60
Tdp-43	encodes	protein	0.60
Raf	expressed_in	protein	0.60
PLIN4	expressed_in	gene	0.60
Er Stress	encodes	pathway	0.60
Cell Cycle	encodes	pathway	0.60
Apoptosis	encodes	pathway	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.58
Cerebellum	expressed_in	brain_region	0.55
Spinal Cord	expressed_in	brain_region	0.55
Ca1	expressed_in	brain_region	0.55

Incoming (30)

Source	Relation	Type	Str
ATXN2	expressed_in	gene	0.60
HNRNPA1	expressed_in	gene	0.60
FUS	encodes	gene	0.60
PLIN4	encodes	gene	0.60
HNRNPA2B1	encodes	gene	0.60
ATXN2	encodes	gene	0.60
HNRNPA1	encodes	gene	0.60
NEURON	expressed_in	gene	0.60
ALS	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
TPRKB	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
TBC1D24	expressed_in	gene	0.60
PLIN4	expressed_in	gene	0.60
FUS	expressed_in	gene	0.60
HNRNPA2B1	expressed_in	gene	0.60
BID	expressed_in	gene	0.60
CCNF	expressed_in	gene	0.60
TDP-43	expressed_in	gene	0.60
MAPT	expressed_in	gene	0.60
CDKN1A	expressed_in	gene	0.60
SMN	expressed_in	gene	0.60
TIA1	expressed_in	gene	0.60
NEURON	encodes	gene	0.60
ALS	encodes	gene	0.60
DEMENTIA	encodes	gene	0.60
ALS2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CNTN4 in their description or question text

No additional research found