gene

RANK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RANK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

413Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RANK is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, Aging, Als. Connected to 235 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RANK (TNFRSF11A)
Full Name	TNF Receptor Superfamily Member 11A
Aliases	TNFRSF11A
Chromosome	18q21.33
Protein Type	Receptor
Function	RANK is a type I transmembrane protein expressed primarily on osteoclast precursors, dendritic cells, and activated T cells[@anderson1997].
Pathways	NF-κB
UniProt ID	Q9Y275
NCBI Gene ID	26986
Ensembl ID	ENSG00000141655
OMIM	603799
Phagocytosis	Critical for clearing amyloid-beta plaques and cellular debris
Cell survival	TREM2 signaling promotes microglial survival in stress conditions
Metabolic adaptation	Supports microglial energy demands during activation
Inflammatory phenotype	Modulates between pro-inflammatory and protective phenotypes
Associated Diseases	Aging, Als, Autoimmune, Cancer, Hypertension
Interactions	Actin, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND
KG Connections	413 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RANK — AlphaFold Q9Y275 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RANK["RANK"]
    RANK -->|"activates"| Neurodegeneration["Neurodegeneration"]
    RANK -->|"activates"| Ms["Ms"]
    RANK -->|"activates"| Als["Als"]
    RANK -->|"interacts"| Alzheimer["Alzheimer"]
    RANK -->|"activates"| Cancer["Cancer"]
    RANK -->|"activates"| Tumor["Tumor"]
    RANK -->|"activates"| Senescence["Senescence"]
    RANKL["RANKL"] -->|"activates"| RANK
    VCP["VCP"] -->|"activates"| RANK
    JUN["JUN"] -->|"activates"| RANK
    SQSTM1["SQSTM1"] -->|"activates"| RANK
    TYROBP["TYROBP"] -->|"activates"| RANK
    ATF4["ATF4"] -->|"regulates"| RANK
    GAIN["GAIN"] -->|"activates"| RANK
    HNRNPA2B1["HNRNPA2B1"] -->|"activates"| RANK
    HNRNPA1["HNRNPA1"] -->|"activates"| RANK

Outgoing (241)

Target	Relation	Type	Str
NFKB	activates	pathway	0.95
Nuclear Factor Kappa B	activates	pathway	0.90
Ischemia	expressed_in	disease	0.75
Als	associated_with	disease	0.75
Tumor	biomarker_for	disease	0.75
Osteoporosis	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Als	activates	disease	0.75
Inflammation	regulates	disease	0.75
Senescence	activates	disease	0.75
Als	biomarker_for	disease	0.75
Inflammation	biomarker_for	disease	0.75
Apoptosis	therapeutic_target	pathway	0.70
Mapk	therapeutic_target	pathway	0.70
Differentiation	activates	pathway	0.70
Ms	associated_with	disease	0.65
ALS	activates	disease	0.65
Aging	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Tumor	activates	disease	0.65
Carcinoma	expressed_in	disease	0.65
Ms	activates	disease	0.65
Als	protects_against	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Inflammation	implicated_in	disease	0.65
Tumor	expressed_in	disease	0.65
Stroke	associated_with	disease	0.65
Cancer	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Als	expressed_in	disease	0.65
Aging	associated_with	disease	0.65
Als	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Autoimmune	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Neurodegeneration	causes	disease	0.65
Ovarian Cancer	regulates	disease	0.65
Carcinoma	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	regulates	disease	0.65
ALS	regulates	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65

Incoming (172)

Source	Relation	Type	Str
TNFRSF11A	associated_with	gene	1.00
TNFRSF11A	encodes	gene	0.95
RANKL	binds	protein	0.95
OSTEOPROTEGERIN	inhibits	protein	0.90
RANKL	regulates	gene	0.80
RANKL	activates	protein	0.72
TNF	regulates	gene	0.70
NEURODEGENERATION	causes	gene	0.60
GENES	causes	gene	0.60
NEUROTOXICITY	causes	gene	0.60
MITOCHONDRIAL DYSFUNCTION	causes	gene	0.60
ATP	causes	gene	0.60
AND	causes	gene	0.60
NEURODEGENERATIVE DISEASES	causes	gene	0.60
SELECTIVE NEURODEGENERATION	causes	gene	0.60
TYROBP	activates	gene	0.60
GAIN	activates	gene	0.60
TRAF6	associated_with	gene	0.60
BECLIN1	inhibits	gene	0.60
ATF4	therapeutic_target	gene	0.60
ABCD3	associated_with	gene	0.60
TIA1	activates	gene	0.60
STAT3	associated_with	gene	0.60
PPARA	associated_with	gene	0.60
IFNG	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
IKBKB	associated_with	gene	0.60
CASP8	associated_with	gene	0.60
TP53	biomarker_for	gene	0.60
PTEN	biomarker_for	gene	0.60
PI3K	biomarker_for	gene	0.60
BRCA2	biomarker_for	gene	0.60
SLC17A7	causes	gene	0.60
TPR	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60
NEFL	interacts_with	gene	0.60
GAP43	interacts_with	gene	0.60
CALM1	interacts_with	gene	0.60
KIF15	interacts_with	gene	0.60
KIF5B	interacts_with	gene	0.60
SST	interacts_with	gene	0.60
PVALB	interacts_with	gene	0.60
AURKB	interacts_with	gene	0.60
NEFH	interacts_with	gene	0.60
CALM1	therapeutic_target	gene	0.60
KIF5B	therapeutic_target	gene	0.60
NEFH	therapeutic_target	gene	0.60
GAP43	therapeutic_target	gene	0.60
SST	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RANK in their description or question text

No additional research found