protein 2,612 words KG: TIA1
Contents

TIA1 Protein

🔬 Protein Info
Gene SymbolTIA1
AliasesPage for TIA1
Chromosome2p16.3
Protein FamilyTIA1/TIAR family
FunctionTIA1 functions as a multifunctional RNA-binding protein with critical roles in several cellular processes.
Subcellular Localization</strong></td><td>Cytoplasm, stress granules</td></tr>
Molecular Weight43 kDa
Amino Acids386 aa
PathwaysEr Stress
UniProt IDP52912
NCBI Gene ID4678
Ensembl IDENSG00000173166
OMIM603518
GeneCardsTIA1
Human Protein AtlasTIA1
Associated DiseasesAls, amyotrophic lateral sclerosis, dementia
Known Drugs/Compoundsrapamycin
InteractionsALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOPTOSIS
KG Connections256 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (13)

Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Axonal RNA Transport Reconstitution
Score: 0.70
Cross-Seeding Prevention Strategy
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
RNA Granule Nucleation Site Modulation
Score: 0.66
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.57
Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (9)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (1)

Stress Granule Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (11)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: activates
ATF4 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

GABARAP associated_with TIA1
ATF4 associated_with TIA1
FMR1 associated_with TIA1
MTOR associated_with TIA1
RRAGA interacts_with TIA1
G3BP1 associated_with TIA1
JUN interacts_with TIA1
RRAGB interacts_with TIA1
TIA1 associated_with EIF2A
JUN activates TIA1

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