gene 532 words KG: SDHA
Contents

SDHA Gene - Succinate Dehydrogenase Complex Subunit A

🧬 Gene Info
Gene SymbolSDHA
Full NameSuccinate Dehydrogenase Complex Subunit A
AliasesPage for SDHA Gene, Page for SDHA Protein
Chromosome5p15.33
Protein TypeEnzyme
FunctionSDHA is a catalytic subunit of succinate dehydrogenase (SDH), a heterotetrameric enzyme that functions in both the Krebs cycle (Complex II of the ETC).
Molecular Weight73 kDa
PathwaysProteasome
UniProt IDP31040
NCBI Gene ID6389
Ensembl IDENSG00000123594
GeneCardsSDHA
Human Protein AtlasSDHA
Krebs CycleCatalyzes succinate to fumarate oxidation
Electron Transport ChainTransfers electrons to ubiquinone
Associated DiseasesParkinson
Interactionsaco2, ACO2, AGING, ATP, ATP5A1, BDNF
KG Connections167 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (10)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (7)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (11)

ATP P2X3 Receptor Neurons
cell · KG edge: activates
Genes
index · KG edge: associated_with
ACO2 — Aconitase 2
gene · KG edge: expressed_in
ACTB Gene
gene · KG edge: regulates
BDNF Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

VDAC1 expressed_in SDHA
HSPA9 expressed_in SDHA
CYCS expressed_in SDHA
ACO2 expressed_in SDHA
GLUD1 therapeutic_target SDHA
SNCA expressed_in SDHA
LRPPRC therapeutic_target SDHA
NDUFS2 therapeutic_target SDHA
NDUFS1 therapeutic_target SDHA
UBIQUITIN contributes_to SDHA

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