gene

aco2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about aco2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

92Connections

0Hypotheses

0Analyses

50Outgoing

20Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ACO2
Full Name	Aconitase 2
Chromosome	22q13.2
Protein Type	Enzyme
Function	is a mitochondrial enzyme that catalyzes the stereospecific isomerization of citrate to isocitrate via cis-aconitate in the second step of the tricarboxylic acid (TCA) cycle[@beinert1996].
Primary Expression	all nucleated cells:
Amino Acids	778 aa
Exons	18
Ensembl ID	ENSG00000100412
GeneCards	ACO2
Human Protein Atlas	ACO2
Four functional domains	Organized around the 4Fe-4S cluster
4Fe-4S cluster binding site	Essential for catalytic activity and redox sensing
Active site	Contains three conserved cysteine residues coordinating the iron-sulfur cluster
Citrate → cis-Aconitate → Isocitrate	Stereochemical isomerization
Associated Diseases	neurodegeneration
Interactions	ATP, ATP5A1, CYCS, GLUD1, HSPA9, IMMUNE INFILTRATION
KG Connections	82 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ACO2 — Aconitase 2

gene · 854 words

→

aco2-protein

protein · 1242 words

→

Pathway Diagram

graph TD
    ACO2["ACO2"]
    ACO2 -->|"involved_in"| TCA_Cycle["TCA Cycle"]
    ACO2 -.biomarker for.-> Parkinson_S_Disease["Parkinson'S Disease"]
    ACO2 -->|"target for"| Parkinson["Parkinson"]
    ACO2 -->|"target for"| GLUD1["GLUD1"]
    ACO2 -->|"expressed in"| SNCA["SNCA"]
    ACO2 -->|"target for"| LRPPRC["LRPPRC"]
    ACO2 -->|"target for"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"target for"| ACO2
    VDAC1["VDAC1"] -->|"expressed in"| ACO2
    HSPA9["HSPA9"] -->|"expressed in"| ACO2
    CYCS["CYCS"] -->|"expressed in"| ACO2
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"] -->|"target for"| ACO2
    OXIDATIVE_STRESS -->|"target for"| ACO2
    GENES["GENES"] -->|"target for"| ACO2
    SNCA -->|"expressed in"| ACO2

Outgoing (72)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ACO2	data_in	dataset_row	0.00
TCA Cycle	involved_in	pathway	0.82
Parkinson'S Disease	biomarker_for	disease	0.75
Parkinson	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
T Cell	therapeutic_target	cell_type	0.60
Neuron	therapeutic_target	cell_type	0.60
HUB GENES	associated_with	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ROS	activates	gene	0.60
ATP	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
IMMUNE INFILTRATION	activates	gene	0.60
GENES	associated_with	gene	0.60
PARKINSON	activates	gene	0.60
Oxidative Phosphorylation	activates	pathway	0.60
Oxidative Stress	activates	pathway	0.60
CACNA1A	regulates	gene	0.60
Oxidative Phosphorylation	therapeutic_target	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
ROS	therapeutic_target	gene	0.60
AND	expressed_in	gene	0.60
CYCS	associated_with	gene	0.60
HSPA9	associated_with	gene	0.60
SDHA	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
VDAC1	associated_with	gene	0.60
ATP5A1	interacts_with	gene	0.60
MDH2	interacts_with	gene	0.60
NDUFS3	interacts_with	gene	0.60
PDHB	interacts_with	gene	0.60
SDHA	interacts_with	gene	0.60
SUCLG1	interacts_with	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
ATP	therapeutic_target	gene	0.60
App	therapeutic_target	protein	0.60
neurons	expressed_in	cell_type	0.60
GLUD1	therapeutic_target	gene	0.60
SNCA	expressed_in	gene	0.60
LRPPRC	therapeutic_target	gene	0.60
NDUFS2	therapeutic_target	gene	0.60
NDUFS1	therapeutic_target	gene	0.60
SDHA	expressed_in	gene	0.60
VDAC1	expressed_in	gene	0.60
CYCS	expressed_in	gene	0.60
HSPA9	expressed_in	gene	0.60
NDUFS1	activates	gene	0.60
NDUFS2	activates	gene	0.60

Incoming (20)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ACO2	data_in	dataset_row	0.00
genes-aco2	describes	wiki_page	0.95
ATP	therapeutic_target	gene	0.60
ROS	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
VDAC1	expressed_in	gene	0.60
HSPA9	expressed_in	gene	0.60
CYCS	expressed_in	gene	0.60
SNCA	expressed_in	gene	0.60
NDUFS1	therapeutic_target	gene	0.60
LRPPRC	therapeutic_target	gene	0.60
SDHA	expressed_in	gene	0.60
LRPPRC	activates	gene	0.60
GLUD1	activates	gene	0.60
GLUD1	therapeutic_target	gene	0.60
NDUFS2	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
IMMUNE INFILTRATION	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning aco2 in their description or question text

No additional research found