gene

NDUFS2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

69Connections

0Hypotheses

0Analyses

40Outgoing

29Incoming

0Experiments

0Debates

Summary

NDUFS2 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, implicated in. Associated with Parkinson. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NDUFS2
Function	The NDUFS2 gene encodes NDUFS2 Protein, a protein involved in various cellular processes relevant to neuronal function and survival.
Primary Expression	various brain regions, with notable expression in: - Cerebral cortex - Hippocampus - Basal gang
Pathways	Oxidative Phosphorylation
Ensembl ID	ENSG00000147684
GeneCards	NDUFS2
Human Protein Atlas	NDUFS2
Associated Diseases	Parkinson
Interactions	ACO2, ATP, CYCS, GENES, HSPA9, HUB GENES
KG Connections	69 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NDUFS2 Gene

gene · 585 words

→

NDUFS2 Protein

protein · 808 words

→

Pathway Diagram

graph TD
    NDUFS2["NDUFS2"]
    Parkinson{"Parkinson"}
    NDUFS2 -->|"therapeutic target"| Parkinson
    NDUFS1["NDUFS1"]
    NDUFS2 -->|"associated with"| NDUFS1
    SDHA["SDHA"]
    NDUFS2 -->|"therapeutic target"| SDHA
    Oxidative_Phosphorylation(["Oxidative Phosphorylation"])
    NDUFS2 -->|"therapeutic target"| Oxidative_Phosphorylation
    Oxidative_Stress(["Oxidative Stress"])
    NDUFS2 -->|"therapeutic target"| Oxidative_Stress
    neurodegeneration["neurodegeneration"]
    NDUFS2 -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"therapeutic target"| NDUFS2
    VDAC1["VDAC1"]
    VDAC1 -->|"therapeutic target"| NDUFS2
    HSPA9["HSPA9"]
    HSPA9 -->|"therapeutic target"| NDUFS2
    CYCS["CYCS"]
    CYCS -->|"therapeutic target"| NDUFS2
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"therapeutic target"| NDUFS2
    ACO2["ACO2"]
    ACO2 -->|"therapeutic target"| NDUFS2
    GLUD1["GLUD1"]
    GLUD1 -->|"associated with"| NDUFS2
    SNCA["SNCA"]
    SNCA -->|"therapeutic target"| NDUFS2
    LRPPRC["LRPPRC"]
    LRPPRC -->|"associated with"| NDUFS2
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"therapeutic target"| NDUFS2
    style NDUFS2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (40)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:NDUFS2	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Oxidative Phosphorylation	involved_in	pathway	0.85
Oxidative Stress	involved_in	process	0.80
Parkinson	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
ROS	therapeutic_target	gene	0.60
Oxidative Phosphorylation	therapeutic_target	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
ATP	therapeutic_target	gene	0.60
App	therapeutic_target	protein	0.60
SNCA	therapeutic_target	gene	0.60
LRPPRC	causes	gene	0.60
HSPA9	therapeutic_target	gene	0.60
CYCS	therapeutic_target	gene	0.60
ACO2	therapeutic_target	gene	0.60
T Cell	therapeutic_target	cell_type	0.60
Neuron	therapeutic_target	cell_type	0.60
IMMUNE INFILTRATION	activates	gene	0.60
GENES	activates	gene	0.60
PARKINSON	activates	gene	0.60
Oxidative Phosphorylation	activates	pathway	0.60
Oxidative Stress	activates	pathway	0.60
CYCS	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
SDHA	activates	gene	0.60
VDAC1	activates	gene	0.60
NDUFS1	associated_with	gene	0.60
SDHA	therapeutic_target	gene	0.60
GLUD1	causes	gene	0.60
VDAC1	therapeutic_target	gene	0.60
SNCA	activates	gene	0.60
Parkinson	associated_with	disease	0.60
AND	causes	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
Neuron	expressed_in	cell_type	0.55
T Cell	expressed_in	cell_type	0.55
SDHA	co_expressed_with	gene	0.50
SNCA	co_expressed_with	gene	0.50

Incoming (29)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:NDUFS2	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
VDAC1	therapeutic_target	gene	0.60
HSPA9	therapeutic_target	gene	0.60
CYCS	therapeutic_target	gene	0.60
ACO2	therapeutic_target	gene	0.60
GLUD1	associated_with	gene	0.60
SNCA	therapeutic_target	gene	0.60
LRPPRC	associated_with	gene	0.60
NDUFS1	causes	gene	0.60
LRPPRC	causes	gene	0.60
SDHA	therapeutic_target	gene	0.60
HUB GENES	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ROS	activates	gene	0.60
ATP	activates	gene	0.60
AND	causes	gene	0.60
ROS	therapeutic_target	gene	0.60
GLUD1	causes	gene	0.60
ACO2	activates	gene	0.60
HSPA9	activates	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
IMMUNE INFILTRATION	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
ATP	therapeutic_target	gene	0.60
NDUFS1	associated_with	gene	0.50
LRPPRC	co_expressed_with	gene	0.50
NDUFS1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NDUFS2 in their description or question text

No additional research found