gene

MDH2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MDH2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

8Outgoing

5Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	MDH2
Chromosome	5p15.33
Protein Type	Gene
Function	Malate dehydrogenase 2 (MDH2) is a mitochondrial enzyme that catalyzes the reversible oxidation of malate to oxaloacetate in the TCA cycle, using NAD+ as a cofactor.
Primary Expression	neurons and astrocytes where it supports oxidative phosphorylation and metabolic coupling
Subcellular Localization	the mitochondrial matrix and plays a central role in cellular energy metabolism, participating in critical metabolic shu
Amino Acids	338 aa
UniProt ID	P40926
GeneCards	MDH2
Human Protein Atlas	MDH2
Associated Diseases	neurodegeneration
Interactions	ACO2, ALDH2, ATP5A1, NDUFS3, PDHB, ROS
KG Connections	13 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MDH2 — AlphaFold P40926 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mdh2

gene · 658 words

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Pathway Diagram

graph TD
    MDH2["MDH2"]
    Ms{"Ms"}
    MDH2 -->|"inhibits"| Ms
    Tumor{"Tumor"}
    MDH2 -->|"inhibits"| Tumor
    Glioblastoma{"Glioblastoma"}
    MDH2 -->|"expressed in"| Glioblastoma
    GBM["GBM"]
    MDH2 -->|"expressed in"| GBM
    neurodegeneration["neurodegeneration"]
    MDH2 -->|"implicated in"| neurodegeneration
    style MDH2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
Ms	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Glioblastoma	expressed_in	disease	0.65
GBM	expressed_in	gene	0.60
NDUFS3	interacts_with	gene	0.60
PDHB	interacts_with	gene	0.60
SDHA	interacts_with	gene	0.60
SUCLG1	interacts_with	gene	0.60

Incoming (5)

Source	Relation	Type	Str
ROS	interacts_with	gene	0.60
AND	therapeutic_target	gene	0.60
ALDH2	interacts_with	gene	0.60
ACO2	interacts_with	gene	0.60
ATP5A1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MDH2 in their description or question text

No additional research found