gene

LRPPRC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRPPRC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

107Connections

0Hypotheses

0Analyses

50Outgoing

33Incoming

0Experiments

0Debates

Summary

LRPPRC in mitochondrial mRNA processing, Leigh syndrome French-Canadian type and neurodegeneration

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	LRPPRC
Chromosome	2p21
Function	LRPPRC encodes a leucine-rich pentatricopeptide repeat (PPR) protein that localizes to mitochondria and is involved in post-transcriptional regulation of mitochondrial gene expression.
Subcellular Localization	</strong></td><td>Mitochondria</td></tr>
Molecular Weight	156 kDa
Amino Acids	394 aa
Exons	38
Pathways	Oxidative Phosphorylation
Ensembl ID	ENSG00000138095
GeneCards	LRPPRC
Human Protein Atlas	LRPPRC
Associated Diseases	Als, Parkinson
Known Drugs/Compounds	donepezil, Donepezil, Duloxetine
Interactions	ACO2, Actin, AND, ATP, AUTOPHAGY, BECN1
KG Connections	107 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LRPPRC Protein

protein · 2294 words

→

LRPPRC — Leucine-Rich Pentatricopeptide Repeat Containing

gene · 1293 words

→

Pathway Diagram

graph TD
    LRPPRC["LRPPRC"]
    BECN1["BECN1"]
    LRPPRC -->|"interacts with"| BECN1
    Parkinson{"Parkinson"}
    LRPPRC -->|"therapeutic target"| Parkinson
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    LRPPRC -->|"therapeutic target"| OXIDATIVE_STRESS
    NDUFS2["NDUFS2"]
    LRPPRC -->|"associated with"| NDUFS2
    NDUFS1["NDUFS1"]
    LRPPRC -->|"associated with"| NDUFS1
    SDHA["SDHA"]
    LRPPRC -->|"therapeutic target"| SDHA
    Oxidative_Phosphorylation(["Oxidative Phosphorylation"])
    LRPPRC -->|"therapeutic target"| Oxidative_Phosphorylation
    Oxidative_Stress(["Oxidative Stress"])
    LRPPRC -->|"therapeutic target"| Oxidative_Stress
    LRPPRC -->|"expressed in"| Oxidative_Phosphorylation
    neurodegeneration["neurodegeneration"]
    LRPPRC -->|"implicated in"| neurodegeneration
    NS1["NS1"]
    NS1 -->|"interacts with"| LRPPRC
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"therapeutic target"| LRPPRC
    VDAC1["VDAC1"]
    VDAC1 -->|"therapeutic target"| LRPPRC
    HSPA9["HSPA9"]
    HSPA9 -->|"therapeutic target"| LRPPRC
    CYCS["CYCS"]
    CYCS -->|"therapeutic target"| LRPPRC
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"therapeutic target"| LRPPRC
    ACO2["ACO2"]
    ACO2 -->|"therapeutic target"| LRPPRC
    GLUD1["GLUD1"]
    GLUD1 -->|"associated with"| LRPPRC
    SNCA["SNCA"]
    SNCA -->|"therapeutic target"| LRPPRC
    style LRPPRC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (74)

Target	Relation	Type	Str
BECN1	interacts_with	protein	0.90
Oxidative Phosphorylation	involved_in	process	0.80
Tumor	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Parkinson	activates	disease	0.65
ALS	stabilizes	disease	0.65
Als	stabilizes	disease	0.65
PARKINSON'S DISEASE	activates	gene	0.60
IMMUNE INFILTRATION	activates	gene	0.60
GENES	activates	gene	0.60
PARKINSON	activates	gene	0.60
Oxidative Phosphorylation	activates	pathway	0.60
Oxidative Stress	activates	pathway	0.60
MITOCHONDRIA	regulates	gene	0.60
Oxidative Phosphorylation	expressed_in	pathway	0.60
HUB GENES	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ROS	activates	gene	0.60
ATP	activates	gene	0.60
ACO2	activates	gene	0.60
HSPA9	activates	gene	0.60
NDUFS1	causes	gene	0.60
SNCA	activates	gene	0.60
SDHA	activates	gene	0.60
VDAC1	activates	gene	0.60
CYCS	activates	gene	0.60
ATP	therapeutic_target	gene	0.60
RNA	encodes	gene	0.60
MITOCHONDRIA	encodes	gene	0.60
Actin	interacts_with	protein	0.60
App	therapeutic_target	protein	0.60
RNA	interacts_with	gene	0.60
oxidative stress response	participates_in	pathway	0.60
RNA	associated_with	gene	0.60
Parkinson	associated_with	disease	0.60
NDUFS2	associated_with	gene	0.60
NDUFS1	associated_with	gene	0.60
SDHA	therapeutic_target	gene	0.60
HERC5	therapeutic_target	gene	0.60
UBIQUITIN	therapeutic_target	gene	0.60
RNF5	therapeutic_target	gene	0.60
ACO2	therapeutic_target	gene	0.60
NDUFS2	causes	gene	0.60
GLUD1	causes	gene	0.60
VDAC1	therapeutic_target	gene	0.60

Incoming (33)

Source	Relation	Type	Str
NS1	interacts_with	protein	0.90
Donepezil	binds	drug	0.75
Duloxetine	binds	drug	0.75
PARKIN	interacts_with	gene	0.70
VDAC1	therapeutic_target	gene	0.60
HSPA9	therapeutic_target	gene	0.60
CYCS	therapeutic_target	gene	0.60
ACO2	therapeutic_target	gene	0.60
GLUD1	associated_with	gene	0.60
SNCA	therapeutic_target	gene	0.60
IMMUNE INFILTRATION	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
NDUFS1	causes	gene	0.60
GLUD1	causes	gene	0.60
NDUFS2	causes	gene	0.60
donepezil	targets	drug	0.60
AUTOPHAGY	activates	gene	0.60
ROS	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
SDHA	therapeutic_target	gene	0.60
PINK1	associated_with	gene	0.60
DOCK2	associated_with	gene	0.60
AND	activates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
RNA	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
ATP	therapeutic_target	gene	0.60
GLUD1	co_expressed_with	gene	0.50
HSPA9	co_expressed_with	gene	0.50
MITOCHONDRIA	associated_with	cell_type	0.50
MITOCHONDRIA	interacts_with	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LRPPRC in their description or question text

No additional research found