Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NDUFS3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NDUFS3 gene encoding mitochondrial complex I core subunit, linked to Parkinson's disease and mitochondrial disorders
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| Gene Symbol | NDUFS3 |
| Chromosome | 19p13.3 |
| Protein Type | Oxidoreductase |
| Function | encodes a core component of mitochondrial complex I (NADH:ubiquinone oxidoreductase), the largest enzyme complex of the electron transport chain[@kirby2004]. |
| Molecular Weight | 30 kDa |
| Ensembl ID | ENSG00000103245 |
| GeneCards | NDUFS3 |
| Human Protein Atlas | NDUFS3 |
| N-terminal domain | Contains the mitochondrial targeting sequence for import |
| Core domain | Houses two [2Fe-2S] iron-sulfur clusters (N1a and N1b) responsible for electron transfer |
| Interface region | Contacts neighboring core subunits (NDUFS2, NDUFV1, NDUFV2) to form the catalytic module |
| Biochemical studies | Complex I activity is reduced by 30-40% in PD substantia nigra pars compacta neurons[@schapira2012] |
| Postmortem analysis | NDUFS3 protein levels and complex I assembly are impaired in PD brains[@zago2018] |
| Genetic associations | Rare variants in complex I subunits, including NDUFS3, have been identified in PD cohorts[@filograna2021] |
| Sporadic PD | The majority of PD cases show complex I dysfunction even without identified genetic mutations[@schapira2012] |
| Associated Diseases | neurodegeneration |
| Interactions | ACO2, ATP5A1, MDH2, PDHB, SDHA, SUCLG1 |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["NDUFS3"]
N1["ACO2"]
N1 -->|"interacts with"| N0
N2["ATP5A1"]
N2 -->|"interacts with"| N0
N3["MDH2"]
N3 -->|"interacts with"| N0
N4["PDHB"]
N0 -->|"interacts with"| N4
N5["SDHA"]
N0 -->|"interacts with"| N5
N6["SUCLG1"]
N0 -->|"interacts with"| N6
N7["neurodegeneration"]
N0 -->|"implicated in"| N7
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class N6 geneHypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NDUFS3 in their description or question text
No additional research found