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protein 1,561 words KG: P60484
Contents

PTEN Protein (Phosphatase and Tensin Homolog)

🔬 Protein Info
Gene SymbolP60484
Protein TypePhosphatase
Functionis a dual-specificity phosphatase that functions as a major negative regulator of the phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway.
Subcellular Localization| Cytoplasm, nucleus, plasma membrane
Molecular Weight47 kDa
Amino Acids403 aa
GeneCardsP60484
Human Protein AtlasP60484
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Purinergic Signaling Polarization Control
Score: 0.71Mechanosensitive Ion Channel Reprogramming
Score: 0.70Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67APOE-Dependent Autophagy Restoration
Score: 0.85

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40

Key Papers (1)

Assessment of the Spatial Distribution of Moisture Content in Granular
Sensors (Basel, Switzerland) 2024

See Also (15)

Neurodegeneration
disease · KG edge: implicated_inBeta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 4 hypothesesIL-6 (Interleukin-6) in Neurodegeneration
biomarker · Pages share 4 hypothesesBEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 4 hypothesesOlfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 4 hypotheses

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