concept

UBIQUITINATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBIQUITINATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

100Connections

5Hypotheses

1Analyses

31Outgoing

50Incoming

1Experiments

2Debates

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💡 Concept Info

Name	UBIQUITINATION
Key Genes/Proteins	UBIQUITIN, UBIQUITIN_LIGASES, USP7
Related Pathways	DIA_MS

Pathway Diagram

graph TD
    UBIQUITINATION["UBIQUITINATION"]
    UBIQUITINATION -->|"modulates"| G3BP1["G3BP1"]
    UBIQUITINATION -->|"regulates"| Protein_Stability["Protein Stability"]
    UBIQUITINATION -->|"mediates"| NLRP3["NLRP3"]
    UBIQUITINATION -->|"modulates"| TDP_43["TDP-43"]
    UBIQUITINATION -->|"regulates"| ATG5["ATG5"]
    UBIQUITINATION -->|"involved_in"| NLRP3_Autophagy_Degradation["NLRP3 Autophagy Degradation"]
    USP7["USP7"] -->|"regulates"| UBIQUITINATION
    PEDV_N["PEDV N"] -->|"involved_in"| UBIQUITINATION
    ubiquitin_ligases["ubiquitin ligases"] -->|"activates"| UBIQUITINATION
    deubiquitinases["deubiquitinases"] -->|"inhibits"| UBIQUITINATION
    MARCH2["MARCH2"] -->|"regulates"| UBIQUITINATION
    UBIQUITIN_LIGASES["UBIQUITIN LIGASES"] -->|"catalyzes"| UBIQUITINATION
    __SYNUCLEIN["Alpha-SYNUCLEIN"] -->|"involved_in"| UBIQUITINATION
    DUBS["DUBS"] -->|"regulates"| UBIQUITINATION

Outgoing (31)

Target	Relation	Type	Str
G3BP1	modulates	entity	0.95
G3BP1	modulates	protein	0.95
Protein Stability	regulates	process	0.95
Autophagy	interacts_with	process	0.90
G3BP1	regulates	protein	0.90
TARDBP	promotes	protein	0.90
breast cancer	associated_with	disease	0.85
NLRP3	mediates	protein	0.85
NLRP3 Autophagy Degradation	involved_in	process	0.85
NLRP3	regulates	protein	0.85
NF-κB Pathway Activation	regulates	process	0.85
Pedv Infection	involved_in	disease	0.85
TDP-43	modulates	protein	0.85
ATG5	regulates	protein	0.85
NLRP3	modulates	protein	0.80
Plin2 Stability	regulates	molecular_function	0.80
protein_degradation	regulates	process	0.80
protein_localization	regulates	process	0.80
NLRP3 Inflammasome Activation	regulates	process	0.80
cellular_physiological_processes	regulates	process	0.80
protein_metabolism	regulates	process	0.80
Nlrp3 Inflammasome	regulates	protein	0.80
xenophagy	regulates	pathway	0.80
PTEN	inhibits	gene	0.80
Protein Degradation	involved_in	process	0.70
synaptic proteome remodeling	regulates	mechanism	0.70
PTEN	regulates	gene	0.70
PEDV_N_protein	regulates	protein	0.64
USP7	regulates	gene	0.60
USP7	inhibits	gene	0.60
VCP	activates	gene	0.60

Incoming (69)

Source	Relation	Type	Str
TARDBP	involved_in	protein	0.95
SPOP	mediates	protein	0.95
PRKN	mediates	protein	0.90
PEDV N	involved_in	protein	0.90
ubiquitin ligases	activates	protein	0.90
deubiquitinases	inhibits	protein	0.90
MARCH2	regulates	protein	0.90
UBIQUITIN LIGASES	catalyzes	enzyme	0.90
Tardbp	associated_with	protein	0.90
LRP1	mediates	protein	0.85
Α-SYNUCLEIN	involved_in	protein	0.85
RAB7A	inhibits	protein	0.85
GPX4	substrate_of	protein	0.80
AIMP2-DX2	inhibits	protein	0.80
SLC25A3	associated_with	protein	0.80
L1-70 FRAGMENT	substrate_of	protein	0.80
selective autophagy	promotes	process	0.80
macroautophagy	interacts_with	process	0.75
MARCHF8	catalyzes	protein	0.72
USP7	regulates	protein	0.72
UBIQUITIN	participates_in	protein	0.72
α-synuclein	undergoes	protein	0.70
circMTCL1	inhibits	protein	0.64
UBIQUITIN_LIGASES	catalyzes	protein	0.64
NLRP3	inhibits	gene	0.60
FASN	activates	gene	0.60
NDP52	regulates	gene	0.60
SNAP29	regulates	gene	0.60
OTUD5	activates	gene	0.60
OTUD5	inhibits	gene	0.60
BNIP3	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
TGM2	activates	gene	0.60
MIRO1	binds_to	gene	0.60
PARKIN	binds_to	gene	0.60
MYC	binds_to	gene	0.60
necroptosis	activates	pathway	0.60
mitophagy	activates	pathway	0.60
RNA	activates	gene	0.60
G3BP1	regulates	gene	0.60
TAK1	activates	gene	0.60
PARKIN	activates	gene	0.60
CAV1	regulates	gene	0.60
PARKIN	regulates	gene	0.60
autophagy	regulates	pathway	0.60
G3BP1	associated_with	gene	0.60
autophagy	activates	pathway	0.60
NLRP3	activates	gene	0.60
LRP1	associated_with	gene	0.60
LRP1	regulates	gene	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CHIP-mediated ubiquitination selectively targets oligomeric	0.590	protein biochemistry	Do chaperones selectively recognize path
TRIM21-Mediated Ubiquitination Creates Peripheral Epitope Gr	0.548	neurodegeneration	What determines the spatial organization
CHIP-mediated K63-linked ubiquitination redirects oligomeric	0.380	protein biochemistry	Do chaperones selectively recognize path
CHIP-mediated K63-linked ubiquitination promotes autophagoso	0.380	protein biochemistry	Do chaperones selectively recognize path
Exposed amyloidogenic segments trigger CHIP-mediated oligome	0.380	protein biochemistry	Do chaperones selectively recognize path

Mentioning Analyses (1)

Scientific analyses that reference this entity

Quantitative proteomics of the aging synapse in early Alzheimer disease

neurodegeneration | 2026-04-04 | 3 hypotheses Top: 0.455

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
TRIM21 E3 ubiquitin ligase screen for stress granule regulation	exploratory	neurodegenerative diseases	0.900	0.00	cultured cells	proposed	N/A

Related Papers (4)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Hsp multichaperone complex buffers pathologically modified Tau. [PMID:35760815]	Unknown	Nat Commun	2022
Treadmill exercise promotes E3 ubiquitin ligase to remove amyloid β and P-tau an [PMID:36195875]	Unknown	J Neuroinflammation	2022
Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S protea [PMID:20478262]	Unknown	Arch Biochem Biophys	2010
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. [PMID:14962978]	Unknown	Hum Mol Genet	2004

Debates (2)

Multi-agent debates referencing this entity

What are the critical protein expression changes and post-translational modifica

closed · Rounds: 4 · Score: 0.68 · 2026-04-12

What are the critical protein expression changes and post-translational modifica

closed · Rounds: 4 · Score: 0.56 · 2026-04-11

Related Research

Hypotheses and analyses mentioning UBIQUITINATION in their description or question text

No additional research found