gene

FYN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FYN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

439Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for FYN — FYN Proto-Oncogene, Src Family Tyrosine Kinase

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🧬 Gene Info

Gene Symbol	FYN
Full Name	FYN Proto-Oncogene, Src Family Tyrosine Kinase
Aliases	Fyn Tyrosine Kinase
Chromosome	6q21.
Protein Type	Receptor
Function	encodes a member of the Src family of non-receptor tyrosine kinases (SFKs).
Primary Expression	T-cells, NK cells, and other immune cells
Molecular Weight	60 kDa
Amino Acids	537 aa
Pathways	Akt, Apoptosis, Dendritic Spine, Endocytosis, Pi3K
UniProt ID	P39687
NCBI Gene ID	2534
Ensembl ID	ENSG00000110881
OMIM	137025
GeneCards	FYN
Human Protein Atlas	FYN
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Interactions	Actin, AD, ADRB2, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	438 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FYN — AlphaFold P39687 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FYN — FYN Proto-Oncogene, Src Family Tyrosine Kinase

gene · 725 words

→

FYN Protein (Fyn Tyrosine Kinase)

protein · 1173 words

→

Pathway Diagram

graph TD
    FYN["FYN"]
    FYN -->|"activates"| STAT3["STAT3"]
    FYN -->|"upregulates"| IL12A["IL12A"]
    FYN -->|"regulates"| Kv1_3["Kv1.3"]
    FYN -->|"causes"| dopaminergic_neuron["dopaminergic neuron"]
    FYN -->|"activates"| neuroinflammation["neuroinflammation"]
    FYN -->|"activates"| microglia_activation["microglia activation"]
    FYN -->|"regulates"| Schizophrenia["Schizophrenia"]
    FYN -->|"regulates"| Epilepsy["Epilepsy"]
    FYN -->|"regulates"| Alzheimer["Alzheimer"]
    FYN -->|"regulates"| Autism["Autism"]
    JUN["JUN"] -->|"regulates"| FYN
    LCK["LCK"] -->|"activates"| FYN
    PKC["PKC"] -->|"activates"| FYN
    SRC["SRC"] -->|"activates"| FYN
    PI3K["PI3K"] -->|"regulates"| FYN
    GENES["GENES"] -->|"activates"| FYN
    NRF2["NRF2"] -->|"activates"| FYN
    CD36["CD36"] -->|"inhibits"| FYN
    AKT["AKT"] -->|"regulates"| FYN
    BACH1["BACH1"] -->|"activates"| FYN

Outgoing (316)

Target	Relation	Type	Str
STAT3	activates	gene	0.95
Dopaminergic Neuron Loss	causes	phenotype	0.95
Mitochondrial Aggregation	causes	phenotype	0.90
RELN	interacts_with	entity	0.90
Microglia Activation	causes	phenotype	0.90
Parkinson'S Disease	risk_factor_for	disease	0.90
PARKINSON'S DISEASE	associated_with	disease	0.85
KV1.3	modulates	gene	0.85
ALZHEIMER'S DISEASE	associated_with	disease	0.85
Parkinson's Disease	risk_factor_for	disease	0.85
KV1.3	upregulates	gene	0.85
KCNA3	modulates	gene	0.85
NEURONAL MIGRATION	involved_in	entity	0.85
NFE2L2	phosphorylates	protein	0.85
KV1.3	phosphorylates	protein	0.80
IL12A	upregulates	gene	0.80
Alzheimer	associated_with	disease	0.75
Aging	expressed_in	disease	0.75
Parkinson	associated_with	disease	0.75
TAU	associated_with	gene	0.70
TREM2	associated_with	gene	0.70
Kv1.3	regulates	protein	0.70
neuroinflammation	activates	process	0.70
dopaminergic neuron	causes	cell_type	0.70
microglia activation	activates	process	0.70
Alzheimer's disease	associated_with	disease	0.70
ALZHEIMER	associated_with	gene	0.70
PARKINSON	associated_with	gene	0.70
MICROGLIA	activates	gene	0.70
Parkinson's disease	associated_with	disease	0.70
Apoptosis	activates	pathway	0.70
Aging	causes	disease	0.65
Diabetes	activates	disease	0.65
Epilepsy	implicated_in	disease	0.65
Autism	implicated_in	disease	0.65
Bipolar	implicated_in	disease	0.65
Schizophrenia	implicated_in	disease	0.65
Depression	implicated_in	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	causes	disease	0.65
Ms	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	activates	disease	0.65
Cancer	regulates	disease	0.65
Als	degrades	disease	0.65
Cancer	biomarker_for	disease	0.65

Incoming (123)

Source	Relation	Type	Str
GSK3B	phosphorylates	gene	0.85
Apoer2	activates	protein	0.85
ABETA	activates	protein	0.80
APOE	expresses	gene	0.70
APP	associated_with	gene	0.70
CLU	expresses	gene	0.70
BIN1	interacts_with	gene	0.70
APOPTOSIS	activates	gene	0.70
DOPAMINERGIC	inhibits	cell_type	0.65
AKT	phosphorylates	entity	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
KV1.3	activates	gene	0.60
PARKINSON	activates	gene	0.60
AND	activates	gene	0.60
AGING	causes	gene	0.60
ALZHEIMER	causes	gene	0.60
TAU PATHOLOGY	causes	gene	0.60
AND	inhibits	gene	0.60
NEURON	causes	gene	0.60
MICROGLIA	activates	gene	0.60
DRD2	associated_with	gene	0.60
PKC	activates	gene	0.60
BACH1	phosphorylates	entity	0.60
AKT	activates	gene	0.60
TMEM106B	inhibits	gene	0.60
GSK3B	associated_with	gene	0.60
IL1B	activates	gene	0.60
STAT3	activates	gene	0.60
CTSB	associated_with	gene	0.60
DYRK1A	associated_with	gene	0.60
APOA1	causes	gene	0.60
BECN1	causes	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
APP/PS1	implicated_in	gene	0.60
AND	phosphorylates	gene	0.60
DEPRESSION	inhibits	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
INFLAMMATION	causes	gene	0.60
APOER2	associated_with	gene	0.60
NRF2	activates	gene	0.60
SNCA	associated_with	gene	0.60
TNFA	activates	gene	0.60
IL12A	activates	gene	0.60
HOMER1	associated_with	gene	0.60
AD	interacts_with	gene	0.60
AΒ	interacts_with	gene	0.60
LCK	activates	gene	0.60
PI3K	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Fyn-anchored dendritic tau/NMDAR signaling persists after tr	0.670	neurodegeneration	Does tau dendritic missorting persist in

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FYN in their description or question text

No additional research found