gene

TET1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TET1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections

2Hypotheses

1Analyses

23Outgoing

11Incoming

0Experiments

1Debates

Summary

Page for TET1 Gene

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🧬 Gene Info

Gene Symbol	TET1
Full Name	Tet Methylcytosine Dioxygenase 1
Chromosome	10q21.3
Protein Type	Gene
Function	Unlike passive demethylation (which occurs during DNA replication without maintenance of methylation marks), TET1-mediated demethylation is an active, enzyme-driven process
Primary Expression	embryonic stem cells and neural progenitor cells, and is essential for pluripotency and neurogenesis
Amino Acids	2136 aa
Pathways	epigenetic regulation, neurotrophin signaling, unfolded protein response
UniProt ID	Q8NFU7
NCBI Gene ID	80312
Ensembl ID	ENSG00000138336
OMIM	607042
GeneCards	TET1
Human Protein Atlas	TET1
CXXC Domain	A cysteine-rich DNA-binding domain that specifically recognizes unmethylated CpG islands, targeting TET1 to promoter regions
Associated Diseases	Rett Syndrome, Alzheimer Disease, Parkinson Disease, Intellectual Disability
Known Drugs/Compounds	Arsenic
Interactions	BDNF, DNA, DNMT1, ERK, GENES, IFN
KG Connections	34 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TET1 — AlphaFold Q8NFU7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TET1 Gene

gene · 2030 words

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Pathway Diagram

flowchart TD
    TET1(["TET1"])
    Inflammation["Inflammation"]
    INFLAMMATION(["INFLAMMATION"])
    DNA(["DNA"])
    GENES(["GENES"])
    Dna_Methylation["Dna Methylation"]
    neurodegeneration["neurodegeneration"]

    TET1 -.->|"inhibits"| Inflammation
    TET1 -.->|"inhibits"| INFLAMMATION
    TET1 -.->|"inhibits"| DNA
    TET1 -.->|"inhibits"| GENES
    TET1 -.->|"inhibits"| Dna_Methylation
    TET1 -->|"implicated in"| neurodegeneration

    style TET1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (23)

Target	Relation	Type	Str
Crohn's Disease	risk_factor_for	disease	0.90
macrophage	regulates	cell_type	0.90
Crohn's Disease-associated inflammation	protects_against	phenotype	0.88
inflammatory signaling	suppresses	pathway	0.88
PTEN	upregulates	gene	0.85
5hmC formation at enhancers	activates	mechanism	0.70
Activity-dependent neuronal gene expression	regulates	phenotype	0.70
neurons	expressed_in	cell_type	0.65
Inflammation	inhibits	disease	0.65
INFLAMMATION	inhibits	gene	0.60
DNA	inhibits	gene	0.60
GENES	inhibits	gene	0.60
Dna Methylation	inhibits	pathway	0.60
CRISPR-Cas	participates_in	pathway	0.60
epigenetic regulation	participates_in	pathway	0.55
unfolded protein response	participates_in	pathway	0.55
neurotrophin signaling	participates_in	pathway	0.55
TET2	activates	gene	0.55
TET3	activates	gene	0.55
TET2	associated_with	gene	0.55
TET3	associated_with	gene	0.55
macrophages	expressed_in	cell_type	0.55
TET2	co_expressed_with	gene	0.50

Incoming (11)

Source	Relation	Type	Str
Arsenic	inhibits	compound	0.85
DNA	activates	gene	0.65
PTEN	activates	gene	0.60
DNMT1	activates	gene	0.60
ERK	activates	gene	0.60
IFN	activates	gene	0.60
BDNF	activates	gene	0.55
OCT4	activates	gene	0.55
DNA	associated_with	gene	0.55
ERK	co_expressed_with	protein	0.50
PTEN	co_expressed_with	gene	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Neuronal TET1 Upregulation Reactivates Immediate-Early Genes	0.640	neurodegeneration	epigenetic reprogramming aging neurons
Targeted DNA Demethylation at the Klotho Locus via dCas9-TET	0.510	neurodegeneration	epigenetic reprogramming aging neurons

Mentioning Analyses (1)

Scientific analyses that reference this entity

Are age-related static epigenetic patterns pathogenic or protective compensatory

epigenetics | 2026-04-15 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate assumed static 5-hydroxymethylcytosine patterns in aging neurons are

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Related Research

Hypotheses and analyses mentioning TET1 in their description or question text

No additional research found