Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about inflammatory pathway: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Late-Onset Alzheimer's Disease | involved_in | disease | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PPARD | regulates | gene | 0.90 |
| Mitochondrial Dysfunction Gene Expression | interacts_with | process | 0.85 |
| TNF | activates | protein | 0.80 |
| LDLR | interacts_with | gene | 0.75 |
| Osteopontin | activates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Hypothesis 2: GPNMB-CD44 Axis as Anti-inflammatory Pathway | 0.772 | neurodegeneration | View |
Scientific analyses that reference this entity
clinical neurology | 2026-04-08 | 7 hypotheses Top: 0.455
Neuroinflammation | 2026-04-03 | 8 hypotheses Top: 0.681
Neuroinflammation | 2026-04-02 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The temporal and stimuli-specific effects of LPS and IFNγ on microglial activati [PMID:41695273] | Heiss CN, Naylor AS, Pesämaa I, Meshi A, | Front Aging Neurosci | 2026 | 0 |
| CD44 connects autophagy decline and ageing in the vascular endothelium. [PMID:37684253] | Unknown | Nat Commun | 2023 | 0 |
| The membrane receptor CD44: novel insights into metabolism. [PMID:35249813] | Unknown | Trends Endocrinol Metab | 2022 | 0 |
| CD44: A Multifunctional Mediator of Cancer Progression. [PMID:34944493] | Unknown | Biomolecules | 2021 | 0 |
| The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the C [PMID:29519253] | ["Matthew L Neal", "Alexa M Boyle", "Kev | Journal of neuroinflammation | 2019 | 0 |
| HAS2 and CD44 in breast tumorigenesis. [PMID:25081531] | Unknown | Adv Cancer Res | 2014 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.79 · 2026-04-09
closed · Rounds: 4 · Score: 0.85 · 2026-04-03
closed · Rounds: 4 · Score: 0.55 · 2026-04-02
Hypotheses and analyses mentioning inflammatory pathway in their description or question text
No additional research found